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Long duration Hormone Deficiency therapy can result in dental problems, need more low vitamin D – Jan 2019

Vitamin D3 and Dental Caries in Children with Growth Hormone Deficiency

International Journal of Endocrinology, Volume 2019, Article ID 2172137, 8 pages, https://doi.org/10.1155/2019/2172137
Dorota Wójcik, dorota.wojcik.dw at gmail.com 1 Leszek Szalewski,1 Elżbieta Pietryka-Michałowska,2 Janusz Borowicz,1 Elżbieta Pels,3 and Iwona Beń-Skowronek4
1 Department of Dental Prosthetics, Medical University of Lublin, Poland
2 Department of Mathematics and Medical Biostatistics, Medical University of Lublin, Poland
3 Chair and Department of Paedodontics, Medical University of Lublin, Poland
4 Department of Paediatric Endocrinology and Diabetology with Endocrine-Metabolic Laboratory, Medical University of Lublin, Poland

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Interesting differences between rural and urban
Dental problems increase with duration of the Therapy

Vitamin D deficiency is a common risk factor for multifactorial diseases, and it seems to be associated with growth hormone deficiency (GHD). Vitamin D could prevent dental caries. The goal of this study was to identify whether there is an association between hormonal therapy with growth hormone (GH), vitamin D3 supplementation, vitamin D3 levels, and the occurrence of caries among children affected by GHD. The study group consisted of patients from the Department of Endocrinology and Diabetology of the University Paediatric Hospital at the Medical University of Lublin treated with recombinant human GH for pituitary GHD. It was conducted between October 2014 and June 2015. The study group included 121 children and adolescents aged 6 to 18 years, with 56 children from rural areas and 65 from urban areas. The study group was stratified by the area of residence. We found the statistically significant impact of vitamin D3 concentration on the average value of the DMFT (decayed, missed, and filled teeth) index and its component—DT (decayed teeth), which was noted in subjects from rural areas. Among patients from urban areas, we found a statistically significant correlation between duration of therapy and the DMFT index. An increase in duration of GH therapy by 10 months leads to a mean increase in DMFT index by 0.70. Based on multiple regression analysis, we developed the following model: value of DT = 3.10 − 0.73category of vitamin D3 concentration − 0.07duration of supplementation (in months). In this model, variables with a significant impact on the value of DT in the group of patients from rural areas include time of vitamin D3 supplementation and category of vitamin D3 concentration. Greater emphasis should be placed on promoting vitamin D3 as a potentially effective agent reducing the number of dental caries, especially among patients with GHD.

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11332 Weeks vs dental.jpg admin 04 Feb, 2019 03:42 52.60 Kb 443
11331 Rural Urban.jpg admin 04 Feb, 2019 03:41 44.79 Kb 474
11330 Growh Hormone Therapy.pdf PDF 2019 admin 04 Feb, 2019 03:41 1.79 Mb 377