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Liver Inflammation (NAFLD) is prevented by Vitamin D – review May 2015

Can Skin Exposure to Sunlight Prevent Liver Inflammation?

Nutrients 2015, 7(5), 3219-3239; doi:10.3390/nu7053219
Shelley Gorman 1,shelley.gorman@telethonkids.org.au. , Lucinda J. Black 1, Martin Feelisch 2, Prue H. Hart 1 and Richard Weller 3
1 Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Western Australia 6008, Australia
2 Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
3 University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, EH16 4TJ, UK

(This article belongs to the Special Issue Immune Regulation by Vitamin D)

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Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation.

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5501 NALFD studies.jpg admin 24 May, 2015 294.90 Kb 1916
5500 NALFD.jpg admin 24 May, 2015 34.44 Kb 7155
5499 nutrients-07-03219.pdf admin 24 May, 2015 317.85 Kb 1197