J Womens Health (Larchmt). 2012 Oct;21(10):1066-73. doi: 10.1089/jwh.2012.3506. Epub 2012 Jun 25.
LeBlanc ES, Rizzo JH, Pedula KL, Ensrud KE, Cauley J, Hochberg M, Hillier TA; Study Of Osteoporotic Fractures.
Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, USA. erin.s.leblanc at kpchr.org
25-Hydroxyvitamin D [25(OH)D] levels are lower in obese individuals. Determining whether low vitamin D status can predispose weight gain requires a longitudinal study.
From a community-based multicenter U.S. prospective cohort of 9704 (Study of Osteoporotic Fractures [SOF]), 4659 women aged ≥65 with baseline 25(OH)D measurement were followed for 4.5 years. They were weighed at baseline and follow-up visits, and a subset (n=1054) had 25(OH)D levels remeasured at follow-up.
Women with 25(OH)D levels ≥30 ng/mL had lower baseline weight (141.6 pounds) compared to women with 25(OH)D levels <30 ng/mL (148.6 pounds) (p<0.001).
Overall, 25(OH)D status was not associated with weight change over 4.5 years, although there was a significant interaction between 25(OH)D status and weight change category (loss, gain, stable) (p<0.0001).
In women who gained ≥5% weight, those with baseline 25(OH)D levels ≥30 ng/mL gained 16.4 pounds (12.2% of baseline weight) over 4.5 years compared to 18.5 pounds (13.9% of baseline weight) in women with levels <30 ng/mL (p=0.04).
In women who lost ≥5% weight or remained stable (<5% weight change), there was no association between 25(OH)D status at baseline and weight change.
Among women who gained weight and had 25(OH)D measured at both visits, having sustained or developing 25(OH)D levels ≥30 ng/mL was associated with less weight gain between visits (14.81 vs. 16.34 pounds, p=0.04).
Higher 25(OH)D levels are associated with lower weight gains, suggesting low vitamin D status may predispose to fat accumulation.
- Overview Obesity and Vitamin D
- All items in Obesity and vitamin D
- All Clinical Trials: Obese or Overweight and Vitamin D INTERVENTION 68 as of Dec 2012
- Vitamin D less than 20 ng associated with 73 pct chance becoming obese in 11 years – May 2012
- Those low on vitamin D were 2.4X more likely to gain weight – June 2013 Premis: low D ==> gain weight
- Obesity epidemic: a perfect storm of deficiency of vitamin D, Magnesium, Iodine, etc – May 2012
- Less overweight if good outdoor environment (more vitamin D from sunshine) – April 2012 2 studdies
- How might Calcium and Vitamin D cause weight loss – Mar 2012
- Obesity (BMI and waist circumference) associated with low vitamin D – Feb 2012
- 4000 IU vitamin D was not enough to reduce obesity – PhD 2010
Less weight gain by senior women if vitamin D levels over 30 ng – Kaiser Dec 2012
- Vitamin D deficiency may cause weight gain CNN, 6 months after the article was published
5039 visitors, last modified 10 Jan, 2015,