Table of contents
- Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
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25 studies in both categories Mortality and Cardiovascular - VitaminDWiki -
7 studies in both categories Mortality and Breathing - VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
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- Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
Ann Intern Med . 2022 Oct 25.doi: 10.7326/M21-3324.
Joshua P Sutherland1 joshua.sutherland at mymail.unisa.edu.au , Ang Zhou 2 , Elina Hyppönen 2 elina.hypponen at unisa.edu.auA few of the mortality charts: All-cause, Cardio, Respiratory, Cancer (need at least 40 ng)
Background: Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
Objective: To assess genetic evidence for the causal role of low vitamin D status in mortality.
Design: Nonlinear Mendelian randomization analyses.
Setting: UK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.
Participants: 307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data.
Measurements: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.
Results: There were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped (P for nonlinearity < 0.001), and risk for death decreased steeply with increasing concentrations until 50 nmol/L. Evidence for an association was also seen in analyses of mortality from cancer, CVD, and respiratory diseases (P ≤ 0.033 for all outcomes). Odds of all-cause mortality in the genetic analysis were estimated to increase by 25% (odds ratio, 1.25 [95% CI, 1.16 to 1.35]) for participants with a measured 25-(OH)D concentration of 25 nmol/L compared with 50 nmol/L.
Limitations: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.
Conclusion: Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels.
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This study underestimates the problem by about 2X by ignoring 6+ genes that reduce Vitamin D levels in blood from getting to cells
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25 studies in both categories Mortality and Cardiovascular This list is automatically updated
- Risk of Cardiovascular death decreased 5X (lowest to highest Vitamin D level)- Feb 2024
- Low Vitamin D associated with CHD, stroke, death, etc, (Mendelian analhysis) - Dec 2021
- Death rates of Cardiovascular patients keep decreasing until 90 nmol of Vitamin D - May 2023
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
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7 studies in both categories Mortality and Breathing This list is automatically updated
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Seniors on mechanical ventilation having very low vitamin D died sooner – July 2012
VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
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Items found: 36
VitaminDWiki - Mortality category contains
People die sooner if they have low vitamin D
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Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study
Clinical NutritionVolume 40, Issue 5, May 2021, Pages 3436-3447 https://doi.org/10.1016/j.clnu.2020.11.019
Joshua P.Sutherland a, AngZhou a Matthew J.Leach b ElinaHyppönen ac
Download the PDF from Sub-Hub via VitaminDWikiLess likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022Printer Friendly Follow this page for updates1140 visitors, last modified 30 Aug, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 18708 Biobank race.jpg admin 25 Oct, 2022 32.13 Kb 214 18707 2020 biobank.jpg admin 25 Oct, 2022 40.39 Kb 243 18706 sutherland2020_CompressPdf.pdf admin 25 Oct, 2022 362.43 Kb 119 18705 Cancer biobank.jpg admin 25 Oct, 2022 30.76 Kb 524 18704 Adjustd Respiratory.jpg admin 25 Oct, 2022 34.77 Kb 330 18703 Respiratory biobank.jpg admin 25 Oct, 2022 35.84 Kb 331 18702 CVD biobank.jpg admin 25 Oct, 2022 24.48 Kb 329 18701 Call cause bio-bank.jpg admin 25 Oct, 2022 24.52 Kb 515 18700 Mortality biobank.pdf admin 25 Oct, 2022 197.00 Kb 122 - VitaminDWiki -