Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis
Maturitas, Available online 2 April 2016, doi:10.1016/j.maturitas.2016.04.002
Cedric Annweilera, b, CeAnnweiler at chu-angers.fr , Morgane Drouetc, Guillaume T Duvala, Pierre-Yves Paréa, Stephanie Leruec, Mickael Dinomaisd, e, Dan Mileac, f, g, h
• Vitamin D may be involved in ocular health and function.
• High concentrations 25-hydroxyvitamin D are associated with less age-related macular degeneration.
• Concentrations of 25-hydroxyvitamin D under 50nmol/L are associated with late-stage age-related macular degeneration.
• These findings provide a scientific basis for vitamin D replacement trials.
Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms “Vitamin D‘OR “Vitamin D deficiency“OR “Ergocalciferols” OR ‘Cholecalciferol’ combined with “Age-related macular degeneration“OR “Macular degeneration“OR “Retinal degeneration“OR “Macula lutea“OR “Retina’. Fixed and random-effects meta-analyses were performed to compute i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies single bond 10 cross-sectional studies and 1 cohort study single bond met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR) = 0.83 [95%CI:0.71–0.97]), notably late AMD (summary OR = 0.47 [95%CI:0.28–0.79]). Circulating 25OHD <50nmol/L was also associated with late-stage AMD (summary OR = 2.18 [95%CI:1.34–3.56]), an association that did not persist when all categories of AMD were considered (summary OR = 1.26 [95%CI:0.90–1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50nmol/L are associated with late AMD.
PDF is available free at Sci-Hub 10.1016/j.maturitas.2016.04.002
- Male late stage Age-Related Macular Degeneration is strongly associated with low vitamin D – July 2014
- Wet AMD 3X less likely if high level of vitamin D – June 2014
- UV and macular degeneration
- Macular Degeneration Twin Study – Vitamin D reduced, smoking increased (by 13X in later study)
The items in both Vision and Genetics:
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015
- Macular degeneration 4X more likely if low vitamin D and a particular gene – May 2013
- Macular Degeneration decreased with UV and perhaps Vitamin D genetics– Oct 2011
- Facts About Age-Related Macular Degeneration NIH
- AMD Wikipedia
- For the Public: What the AREDS Means for You NIH May 2013
"reduced the risk of advanced AMD by about 25 % over a five-year period."
and ZERO risk reducion in those people who did not already have non-advanced AMD
- Low Vitamin D Levels Linked to Macular Degeneration Risk
Medscape review of this study - April 2016
Comment by Henry Lahore @ VitaminDWiki: I realize now that the 5 years of my taking AREDS was totally wasted