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Language understanding by infant is associated with vitamin D level during pregnancy – Dec 2015

Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study

Nutrients 2015, 7, 9918–9930; doi:10.3390/nu7125499
Frances A. Tylavsky 1,2,*, Mehmet Kocak 1, Laura E. Murphy 3,4, J. Carolyn Graff 4,5

Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D status is associated with early childhood cognitive and receptive language development. The Conditions Affecting Neurocognitive Development and Learning in Early Childhood Study (CANDLE) study enrolled 1503 mother-child dyads during the second trimester of healthy singleton pregnancies from Shelby County TN. Among 1020 participants of the total CANDLE cohort for whom 25(OH)D levels were available, mean gestational 25(OH)D level during the second trimester was 22.3 ng/mL (range 5.9–68.4), with 41.7% of values <20 ng/dL. Cognitive and language scaled scores increased in a stair-step manner as gestational 25(OH)D levels in the second trimester rose from <20 ng/dL, through 20–29.99 ng/dL, to ě30 ng/dL. When controlling for socioeconomic status, race, use of tobacco products, gestational age of the child at birth, and age at the 2-year assessment, the gestational 25(OH)D was positively related to receptive language development (p < 0.017), but not cognitive or expressive language.

Clipped from Discussion
To our knowledge, this is the largest prospective study to date examining the potential impact of
gestational 25(OH)D status upon early childhood cognitive and language development in a racially
diverse population. We found that higher gestational 25(OH)D status significantly associated with
higher scaled scores for receptive language in offspring at 2 years of age.

In humans, 25(OH)D levels during pregnancy have been positively associated with
neurocognitive development in some [14,16] but not all studies [40–42]. Our observations support
that language development is positively associated with gestational 25(OH)D levels as early as
2 years, while Whitehouse et al., showed an effect as late as age 7 [14].

Similarly, an effect estimate of 0.24 for receptive and 0.12 for expressive
language scaled score per 10 ng/dL increase in 25(OH)D translates into an increase of 1.0 and 0.6 IQ
point respectively by age 2. The reduction in lifetime earnings has been estimated at $22,000 lost
for each 1 IQ point decrease [44].

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Increasing Vitamin D levels in infants will probably increase Language Reception
Vitamin D levels can be increased during pregnancy by:

Thus, $4.00 of Vitamin D during pregnancy may result in $22,000 additional lifetime income

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Infant-Child Intervention trials using Vitamin D:

Attached files

ID Name Comment Uploaded Size Downloads
6205 Receptive Language Development.pdf PDF 2015 admin 02 Dec, 2015 13:54 385.67 Kb 497
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