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Intensely exercising muscles (rats) increases their vitamin D reception capability.– Sept 2015


Acute resisitance exercise increased VDR activation for a few hours - Sept 2015

Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle
Image
Yuhei Makanae1, Riki Ogasawara2, Koji Sato3, Yusuke Takamura3, Kenji Matsutani3, Kohei Kido3, Naruhiro Shiozawa3, Koichi Nakazato4 andSatoshi Fujita3,*
Experimental Physiology. DOI: 10.1113/EP085207

VitaminDWiki comment

Perhaps intensely exercised muscles want more vitamin D to do one or both of the following:

  1. Repair themselves
  2. Increase strength

Note: I have have used intense exercise once every 3 weeks for the past decade
Infrequent extreme exercise (3 reps at max weight) works extremely well.
Update 2017: My high intensity exercise is now done every 2 to 3 days


Vitamin D and vitamin D receptor (VDR) are involved in maintaining skeletal muscle mass and function. Although resistance exercise is well known to enhance muscle growth and improve muscle function, the effect of resistance exercise on VDR has been unclear. We investigated intramuscular VDR expression in response to an acute bout of resistance exercise and endurance exercise. Male adult Sprague-Dawley rats were subjected to either resistance exercise (isometrically exercised via percutaneous electrical stimulation for 5 sets of ten 3-s contractions, with a 7-s interval between contractions and 3-min rest intervals between sets) or endurance exercise (treadmill at 25 m min−1 for 60 min). Rats were killed immediately or 1, 3, 6, or 24 h after completion of the resistance or endurance exercise, and gastrocnemius muscles were removed. Non-exercise control animals were killed in a basal state (control group). Intramuscular VDR expression was significantly higher immediately after resistance exercise and elevated for 3 h after exercise compared with the control group (P < 0.05), and the resistance exercise significantly increased phosphorylated ERK1/2 and Mnk1 expression (P < 0.05), which may be associated with VDR expression, immediately after exercise. Additionally, intramuscular cytochrome P450 27B1 expression, an enzyme related to vitamin D metabolism, was significantly higher at 1 and 3 h after exercise (P < 0.05) compared with the control group. In contrast, endurance exercise had no effect on any of the measured proteins. Our results indicate that resistance exercise may be an efficient way to increase intramuscular VDR and related enzyme expression.

14 citations of article by April 2019

Google Scholar includes

  • Vitamin D and muscle trophicity - 2017
  • Role of nuclear receptors in exercise-induced muscle adaptations - 2017
  • The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults - 2018

See also VitaminDWiki

Athletes are helped by vitamin D by:

  1. Faster reaction time
  2. Far fewer colds/flus during the winter
  3. Less sore/tired after a workout
  4. Fewer micro-cracks and broken bones
  5. Bones which do break heal much more quickly
  6. Increased VO2 and exercise endurance Feb 2011
  7. Indoor athletes especially need vitamin D
  8. Professional indoor athletes are starting to supplement with vitamin D or use vitamin D beds
  9. Olympic athletes have used UV/vitamin D since the 1930's
  10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
  11. Reduced muscle fatigue with 10,000 IU vitamin D daily
  12. Muscle strength improved when vitamin D added: 3 Meta-analysis
  13. Reduced Concussions
    See also: Sports and Vitamin D category 210 items

Pages listed in BOTH of the categories Vitamin D Receptor and Sports


Acute high intensity interval exercise reduces colon cancer cell growth - April 2019

No mention of Vitamin D Receptor
Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this anti‐oncogenic effect are not clear. In the present study, colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85–95% peak heart rate) was completed with serum samples collected at baseline, as well as 0 and 120 min post‐exercise. For the ‘chronic’ intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo‐2 and LoVo) for up to 72 h and assessing cell number. Serum obtained immediately following HIIE, but not 120 min post‐HIIE, significantly reduced colon cancer cell number. Significant increases in serum interleukin‐6 (P = 0.023), interleukin‐8 (P = 0.036) and tumour necrosis factor‐α (P = 0.003) were found immediately following acute HIIE. At rest, short‐term HIIE training did not promote any changes in cellular growth or cytokine concentrations. The acute effects of HIIE and the cytokine flux may be important mediators of reducing colon cancer cell progression. Repetitive exposure to these acute effects may contribute to the relationship between exercise and improved colorectal cancer survival.
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Attached files

ID Name Comment Uploaded Size Downloads
11789 Devin_et_al-2019-The_Journal_of_Physiology.pdf PDF 2019 admin 22 Apr, 2019 22:00 232.50 Kb 33
6055 Resistance and VDR.jpg admin 17 Oct, 2015 16:25 9.21 Kb 812
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