Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial.
Pediatr Infect Dis J. 2018 Jan 8. doi: 10.1097/INF.0000000000001890. [Epub ahead of print]
- Overview Influenza and vitamin D
- 7X less risk of influenza if Vitamin D levels higher than 30 ng (no shot needed) – Oct 2017
- Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015
- Influenza vaccine meta-analysis found moderate protection – Lancet Oct 2011 “such protection is greatly reduced or absent in some seasons” vs Vitamin D works in all seasons
- 10X reactions to flu vaccine when vitamin D deficient
- This Vitamin Shown to Be Almost 10 Times More Effective Than the Flu Shot – Feb 2017
- Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
- Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017
- RSV (bronchitis and viral pneumonia) in infants associated with low vitamin D and antibiotics – Aug 2015
Items in both categories Infant/Child and Immunity are listed here:
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- Infection in first six months of life: White 69 percent, Black, 78 percent – Jan 2018
- Influenza -A infections half as often in children getting 1200 IU of vitamin D – RCT Jan 2018
- Child is 2 X more likely to get influenza if have older sibling (perhaps closely-spaced birth) – Sept 2017
- Vitamin D does not help children (if only use 400 IU of D3 or D2 or quarterly) – Cochrane Nov 2016
- Vitamin D improves a child’s immune system – can now be claimed in Europe – Sept 2016
- Rotavirus diarrhea (nearly every child gets it) is strongly associated with low vitamin D – Aug 2015
- Immune System response of infants is associated with higher levels of vitamin D – RCT Nov 2014
- Infant sepsis strongly associated with low vitamin D – Aug 2014
- Middle ear infection (Otitis Media) and Vitamin D – many studies
- Tonsillectomy may be an indicator of low vitamin D status
- Many infant infections avoided with supplementation with 400 IU of vitamin D – Oct 2012
- Children with TB vaccinations became 6X more likely to have vitamin D gt than 30 ng – Jan 2012
Note:Flu lasted about half as long for those with vitamin D
Zhou J1, Du J1, Huang L2, Wang Y3, Shi Y3, Lin H2.
1 Department Of Pediatrics, The First People's Hospital Of Yongkang, China.
2 Dept Of Pediatrics, The Second Affiliated Hospital And Yuying Children's Hospital Of Wenzhou Medical U., Wenzhou, China.
3 Department Of Pediatrics, Jinhua People's Hospital, Jinhua, China.
This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants in a multicenter, randomized, open, controlled clinical trial.
The infants were randomized into low-dose and high-dose vitamin D groups, and serum calcium, inorganic phosphorus and 25-hydroxyvitamin D levels were detected thrice in 4 months. Infants infected with influenza A were monitored for symptoms including fever, cough, and wheezing. Pathogen levels and safety of vitamin D treatment were also evaluated.
Of 121 cases in total, 78 and 43 cases of influenza A infection occurred in the low-dose and high-dose vitamin D groups, respectively. There was a significant difference between the groups (χ = 14.6324, P = 0.0001). Among the cases of influenza infection, the median durations for fever, cough, and wheezing were shorter in the high-dose vitamin D group than in the low-dose vitamin D group. The viral loads showed a downward trend in both groups, and were significantly different between the groups at the second and third detections. Additionally, the incidences of adverse events and severe adverse events were very low and not significantly different between the two groups.
High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads, and disease recovery. In addition, high-dose vitamin D is probably safe for infants.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
PMID: 29315160 DOI: 10.1097/INF.0000000000001890