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Infections and low vitamin D

VitaminDWiki

Fact Many infections are associated with low vitamin D

Fact Many infections are treated by Vitamin D

Fact Many infections are prevented by higher levels of Vitamin D

Apparently Low vitamin D levels are both a cause and a result of severe infections
Unknown Can Vitamin D treat and prevent Deep Neck Infections?
Unknown Does the Vitamin D Receptor or other genes limit vitamin D from getting to deep neck tissues


Immunity category which starts with

262 items in Immunity category

    see also

Virus category listing has 1336 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D

18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
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47 studies are in both Immunity and Virus categories

204 Vitamin D pages contained "infection" in title (March 2024)

Items found: 204
Title Modified
Zika in Florida – 1 local infection, 11 new reported in one day, 263 for the year - July 20, 2016 09 Aug, 2016
Risk of local Zika infections – model with global map – April 2016 07 Aug, 2016
Zika Virus Infects Human Placental Macrophages – May 2016 05 Aug, 2016
Infection fighting ability increased with 5,000 IU Vitamin D daily – April 2015 10 Jul, 2016
Urinary tract infection in children strongly associated with low vitamin D – Feb 2015 05 Jul, 2016
Hypothesis – Vitamin D help MicroRNAs reduce Virus Infection – April 2016 29 Jun, 2016
Zika study of microcephaly following symptoms of infection in Columbia – NEJM June 2016 17 Jun, 2016
Of US pregnant women who were tested for Zika, 279 were positive – how many are actually infected - May 2016 17 Jun, 2016
Infections, vitamin D and genes – detailed review – Feb 2014 12 Jun, 2016
Zika virus infection and pregnancy – not much can be done – April 2016 30 May, 2016
Infections infographic 27 May, 2016
Dengue virus infection treated by (active) Vitamin D in the lab – April 2012 20 May, 2016
Lower respiratory tract infections in children associated with Low Vitamin D – meta-analysis May 2016 15 May, 2016
Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012 15 May, 2016
Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015 15 May, 2016
Dengue Antibodies appear to enhance Zika Infection – April 2016 01 May, 2016
Hypothesis: Leishmania parasitic infection can be reduced by Vitamin D – May 2015 14 Feb, 2016
Staph infections with eczema reduced with 2,000 IU of vitamin D – RCT Oct 2015 13 Feb, 2016
Staph infection reduced 50 percent when have more than 30 ng of vitamin D – Aug 2011 13 Feb, 2016
100X reduced chance of visitors getting Zika infection 08 Feb, 2016
Acute respiratory infection worsened by too infrequent vitamin D supplementation – RCT June 2015 17 Dec, 2015
Cirrhosis infection and death both associated with low vitamin D – June 2015 19 Nov, 2015
1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014 20 Oct, 2015
Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015 18 Apr, 2015
Respiratory Infection associated with vitamin D less than 40 ng – March 2015 18 Apr, 2015
Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 24 Mar, 2015
Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013 24 Mar, 2015
Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 20 Mar, 2015
Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 20 Mar, 2015
Reduced viral respiratory tract infections by half by having more than 38 ng of vitamin D – June 2010 29 Oct, 2014
Acute Lower Respiratory Infections in Children: 13 of 18 studies found associations with low vitamin D – meta-analysis Dec 2014 23 Oct, 2014
Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010 18 Oct, 2014
Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014 04 Oct, 2014
Inflammation, infection, active vitamin D, and Olmesartan - Sept 2014 03 Oct, 2014
Infection panacea – vitamin D increases Cathelicidins – March 2014 26 Sep, 2014
The role of vitamin D in prevention and treatment of infection – Aug 2013 26 Sep, 2014
Joint replacement infection associated with low vitamin D – April 2014 02 Aug, 2014
Far fewer lower respiratory tract infections at 36 months if good vitamin D during pregnancy – Nov 2013 18 Jul, 2014
Respiratory viral infections might be prevented by vitamin D supplementation in those with low vitamin D – Sept 2014 18 Jul, 2014
Infection panacia – vitamin D increases Cathelicidins – March 2014 08 Apr, 2014
Hospital-Acquired Infections 3X more likely after Gastric Bypass if less than 30 ng vitamin D – Feb 2014 27 Feb, 2014
2X more childhood diarrhea or ear infection if less than 20 ng of vitamin D – Jan 2013 13 Feb, 2014
Upper respiratory tract infection 2X more likely if vitamin D less than 30 ng – Aug 2013 12 Feb, 2014
Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012 28 Oct, 2013
Vitamin D reduced bacterial infection in cows – RCT Sept 2013 11 Oct, 2013
Additional 4 ng of vitamin D reduced chance of infection by 7 percent – June 2011 10 Oct, 2013
ICU Acinetobacter baumannii infection (Iraqibacter) is 2.5X more likely if low vitamin D – Oct 2013 21 Sep, 2013
2X more likely to get hospital infection if low vitamin D (10 ng) when enter – Oct 2013 21 Sep, 2013
Vitamin D and respiratory tract infections - Wikipedia June 2013 29 Jun, 2013
Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011 23 Jun, 2013
Many infant infections avoided with supplementation with 400 IU of vitamin D – Oct 2012 23 May, 2013
Vitamin D deficiency in HIV-infected and un-infected women in the US – April 2011 26 Oct, 2012
Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT Aug 2012 25 Aug, 2012
Bacterial infection in cows reduced with vitamin D – Oct 2011 07 Feb, 2012

Are Vitamin D Levels Associated With Risk of Deep Neck Infection? - Sept 2019

Ear Nose and Throat Journal https://doi.org/10.1177/0145561319865498
Mustafa Sıtkı Gozeler, MD, Muhammed Sedat Sakat, MD, Korhan Kilic, MD, ...
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 Download the PDF from VitaminDWiki

Deep neck infection (DNI) refers to infections in spaces created by superficial and deep cervical fascia around the muscles and organs in the neck. Vitamin D is highly important for an effective immune system. Vitamin D receptors (VDR) have been identified in immune system cells, and particularly in T and B lymphocytes, macrophages, and dendritic cells. Vitamin D deficiency is thought to result in impaired immune response, decreased leukocyte chemotaxis, and an increased disposition to infection. The purpose of this study was to investigate whether vitamin D deficiency is an underlying occult factor in the development of DNI. Sixty-five patients aged 6 to 90, diagnosed with DNI, and 70 healthy age- and sex-compatible cases were included in the study. Serum levels of calcium, phosphorus, parathyroid hormone, and 25-hydroxy vitamin D (25(OH)D) were determined in each case. 25-hydroxy vitamin D levels above 20 ng/mL were regarded as normal, 12 to 20 ng/mL as insufficient, 5 to 12 ng/mL as deficient, and less than 5 ng/mL as severely deficient.
Mean serum 25(OH)D levels were

  • 10.4 (6.2) ng/mL in the patient group and
  • 15.5 (6.4) ng/mL in the control group (P < .01).

This difference was statistically significant (P < .01). Vitamin D was within normal limits in 9.2% (n = 6) of cases in the study group, insufficient in 29.2% (n = 19), deficient in 35.3% (n = 23), and severely deficient in 26.2% (n = 17). The equivalent values in the control group were 21.4% (n = 15), 48.5% (n = 34), 30% (n = 21), and 0% (n = 0). Serum 25(OH)D levels were significantly lower in patients with DNI compared to the healthy cases; 25(OH)D levels may be a factor in the development of DNI.


Deep neck infections: A single-center analysis of 63 cases - Sept 2017

Med Oral Patol Oral Cir Bucal. 2017 Sep; 22(5): e536–e541, online 2017 Aug 16. doi: 10.4317/medoral.21799
Philipp Kauffmann,corresponding author1 Robert Cordesmeyer,1 Markus Tröltzsch,1 Christian Sömmer,1,2 and Rainer Laskawi3

Background and Purpose
With the use of antibiotic therapy, the incidence of deep neck infections has decreased in recent decades. The aim of this investigation was to review the clinical course and the management of deep neck infections in our department, compare them to the experiences of the common literature and identify predisposing factors for lethal complications.

Material and Methods
In this single-center analysis, 63 patients with deep neck infections were treated surgically. The following clinical data were analyzed and compared: age, gender, laboratory data, spatial manifestation, therapeutic modalities, comorbidities, length of hospitalization and complications.

Results
There was a predominance of male patients (58.7%) and a mean age of 57.9 years. The most common symptoms at diagnosis were sore throat (96.8%) and neck swelling (92.0%). Cardio/pulmonary diseases and diabetes mellitus were the most common comorbidities. There was a significantly longer hospital stay for patients with diabetes mellitus. The most common manifestation was a parapharyngeal abscess in 24 patients (38.1%), followed by peri-/retrotonsillar infections in 19 patients (30.2%). In 29 patients, a multiple space infection was observed, with a significantly longer duration of hospitalization and a higher rate of complications. The main life-threatening complication was the development of airway obstruction in 20 patients (31.7%), who all received a tracheostomy. The duration of hospitalization for patients with complications was significantly longer.

Conclusions
Close attention must be paid to the management of patients with deep neck infections, especially patients with diabetes mellitus and cardio/pulmonary diseases or patients with multiple space infections.

 Download the PDF from VitaminDWiki

Deep Neck Infection Symptoms - Sept 2017

# of infections with a symptom (not %)
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Created by admin. Last Modification: Sunday March 3, 2024 21:15:02 GMT-0000 by admin. (Version 26)

Attached files

ID Name Comment Uploaded Size Downloads
12760 DNI symptoms.jpg admin 08 Oct, 2019 33.75 Kb 2057
12759 DNI Sept 2017.pdf admin 08 Oct, 2019 448.96 Kb 879
12758 DNI levels.jpg admin 08 Oct, 2019 18.32 Kb 1993
12757 DNI.pdf admin 08 Oct, 2019 113.00 Kb 844