The Establishment of Cow's Milk Protein Allergy in Infants is Related with a Deficit of Regulatory T cells (Treg) and Vitamin D.
Pediatr Res. 2017 Jan 18. doi: 10.1038/pr.2017.12. [Epub ahead of print]
García LP1, Muñoz JL2, Alonso-Lebrero E3, Reula ES2,4, Pion M2, Correa-Rocha R2.
- 1Department of Bioactivity and Food Analysisof theCIAL-CSIC, Madrid (Spain).
- 2Laboratory of Immune-regulation, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (Spain).
- 3Pediatric-Allergy Division, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (Spain).
- 4Immunology and Allergy Pediatric Division of the Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (Spain).
Cow's milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors between allergy and tolerance, and hence could be implicated in the CMPA establishment in infants.
An extensive analysis of immune subsets, including Treg and cytokine-secreting cells was performed in blood samples from 28 infants younger than 9 months obtained 1-4 days after the first adverse reaction to milk.
Less than 4 days after first allergic reaction, infants who developed CMPA had decreased Treg counts and increased frequency of IL4-secreting CD4 T cells compared to controls. The deficit of Tregs was correlated with decreased serum levels of vitamin D. Values of Tregs, IL4-secreting cells and vitamin D were good predictors of CMPA diagnosis.
Basal vitamin D levels in CMPA infants also predicted those CMPA patients developing spontaneous tolerance in the first year.
Establishment of CMPA in infants was related with lower Treg and vitamin D levels. These immune alterations would be crucial factors behind the CMPA establishment and they could constitute a therapeutic target for treatment of CMPA.Pediatric Research (2017);
PMID: 28099424 DOI: 10.1038/pr.2017.12
- Low fat milk provides 2.5 times less vitamin D – May 2016
wonder how many infants who become allergic to cow's milk drank low-fat milk
- Children 7 times more likely to be vitamin D deficient if drink cows milk without vitamin D – April 2016
EVen lower levels of vitamin D if the cows milk is not fortified with Vitamin D
- Allergy - Overview which has the following
Food Allergy 5X more likely if low vitamin D – Oct 2014
Food allergies in children 40 % more likely in urban areas (which have less vitamin D) – Sept 2012
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- Food allergies are associated with Vitamin D thru genes, etc. – March 2018
- Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017
- Food allergies and low vitamin D – thymus may be the connection – June 2016
- Food allergies 6 times higher in South Australia - 2009
- Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015
- Kawasaki disease (strawberry tongue) associated with very low vitamin D – May 2015
- Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
- Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014
- Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014
- 11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013
- 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
- High level of maternal vitamin D and infant food allergy – controversy
- Youths with autoimmunity disorders were 2.3 X more likely to be vitamin D deficient – July 2012
- Still unsure of association between vitamin D and asthma and allergies – review April 2012
- Allergy - Overview
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- More childhood allergies when vitamin D is less than 15 ng – Feb 2011
- Milk Allergy Fooed Allergy Research and Education (before 2017)
"Allergy to cow’s milk is the most common food allergy in infants and young children. Symptoms of a milk allergy reaction can range from mild, such as hives, to severe, such as anaphylaxis. "
- "Approximately 2.5 percent of children younger than three years of age are allergic to milk. Nearly all infants who develop an allergy to milk do so in their first year of life. Most children eventually outgrow a milk allergy."
- :Milk allergy should not be confused with lactose intolerance. A food allergy is an overreaction of the immune system to a specific food protein. When the food protein is ingested, in can trigger an allergic reaction that may include a range of symptoms from mild symptoms (rashes, hives, itching, swelling, etc.) to severe symptoms (trouble breathing, wheezing, loss of consciousness, etc.). A food allergy can be potentially fatal.