Table of contents
Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths—A Modeling Study
Nutrients 2021, 13(11), 3986; https://doi.org/10.3390/nu13113986
by Tobias Niedermaier 1,*ORCID,Thomas Gredner 1,2,Sabine Kuznia 1,2,Ben Schöttker 1,3ORCID,Ute Mons 1,4,5ORCID andHermann Brenner 1,3,6,7,*ORCID
1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
2 Medical Faculty Heidelberg, Heidelberg University, 69117 Heidelberg, Germany
3 Network Aging Research (NAR), Heidelberg University, 69117 Heidelberg, Germany
4 Faculty of Medicine and University Hospital Cologne, University of Cologne, 50923 Cologne, Germany
5 Cancer Prevention Unit, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
6 Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
7 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Meta-analyses of randomized controlled trials (RCTs) have estimated a 13% reduction of cancer mortality by vitamin D supplementation among older adults. We evaluated if and to what extent similar effects might be expected from vitamin D fortification of foods. We reviewed the literature on RCTs assessing the impact of vitamin D supplementation on cancer mortality, on increases of vitamin D levels by either supplementation or food fortification, and on costs of supplementation or fortification. Then, we derived expected effects on total cancer mortality and related costs and savings from potential implementation of vitamin D food fortification in Germany and compared the results to those for supplementation. In RCTs with vitamin D supplementation in average doses of 820–2000 IU per day, serum concentrations of 25-hydroxy-vitamin D increased by 15–30 nmol/L, respectively. Studies on food fortification found increases by 10–42 nmol/L, thus largely in the range of increases previously demonstrated by supplementation. Fortification is estimated to be considerably less expensive than supplementation. It might be similarly effective as supplementation in reducing cancer mortality and might even achieve such reduction at substantially larger net savings. Although vitamin D overdoses are unlikely in food fortification programs, implementation should be accompanied by a study monitoring the frequency of potentially occurring adverse effects by overdoses, such as hypercalcemia. Future studies on effectiveness of vitamin D supplementation and fortification are warranted.
VitaminDWiki
Fortification with Vitamin D
Fortification works, even if food is cooked, but govts rarely fortifiy with enough
Govts, food producers, and families can fortify:
milk, yogurt, beer, bread, cereals, cooking oil, soups, jams, jellys, honey, snack bars, etc.
Some interesting fortification articles
- After years of adding vitamin D, Finland now has 38 ng levels - March 2022
- Fortification with Vitamin D works – 16 studies of Danish experience – July 2021
- Vitamin D fortification of beverages – Review March 2022
- Bread fortified with Vitamin D - many studies 13+ studiess
- International Conference of Vitamin D Fortification of Food (India) – Sept 2018
- 2400 IU of vitamin D needed to get most Northern adults above 20 ng – June 2020
- Most Fortification studies do not give enough to make a difference
- Vitamin D home fortification- don't wait 100 years for your govt
Bread Fortification
VitaminDWiki Fortification pages with BREAD in title
This list is automatically updated
Change of Vitamin D Fortification in Denmark
- 60 percent more life births after infertility diagnosis if Vitamin D fortification (Denmark) - Nov 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Vitamin D added to margarine reduced inflammatory bowel disease by 13 percent 30 years later – Nov 2019
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Danish study of childhood diseases vs vitamin D fortification – May 2013
- 9 studies by Denmak D-Tech group (fortifiy Margarine with Vitamin D) online as of Nov 2019
Cost savings with Vitamin D includes the following
- Vitamin D has been found to be cost-effective by many studies
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- People with extremely low vitamin D levels consume 2X more health care dollars – 2018
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Medical problems are thought to be a cause of 66 percent of bankruptcies – April 2019
- Vitamin D is the 3rd most important contributor to health, following exercise and food
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Employers gain 10 dollars in productivity for every dollar spent on giving Vitamin D for free
- Employers should give night shift workers free vitamin D – GMB Union June 2019
- Biology of Vitamin D – 30ng min., 50ng preferred, 1000X lower cost than health problem – Feb 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Dutch Vitamin D cost-effectivity Calculations (they prescribe 100,000 IU for Multiple Sclerosis) – Jan 2022
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- If you cannot readily get medical treatment, consider Alternative Med such as vitamin D
Mortality starts with:
People die sooner if they have low vitamin D
click on image for details
Optimum category starts with:
The RDA is barely enough for the bones to survive.
Need an optimal level for the body to thrive
Example pages
- Is 50 ng of vitamin D too high, just right, or not enough
- More than 30 ng of vitamin D is needed for many diseases - Feb 2022 has
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
- Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
- Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
- Hypothesis by VitaminDWiki – Vitamin D levels are no longer limited by evolution
- VitaminDWiki pages with HIGH-DOSE in title 57 as of Feb 2022
Mortality category with CANCER in title
This list is automatically updated
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