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- Vitamin D supplementation and the outcomes of critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials
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19 Meta-analyses in Trauma-Surgery categories
Vitamin D supplementation and the outcomes of critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials
Scientific Reports volume 10, Article number: 14261 (2020)
Shao-Huan Lan, Chih-Cheng Lai, Shen-Peng Chang, Li-Chin Lu, Shun-Hsing Hung & Wei-Ting LinThis meta-analysis assessed the association between vitamin D supplementation and the outcomes of critically ill adult patients. A literature search was conducted using the PubMed, Web of Science, EBSCO, Cochrane Library, Ovid MEDLINE, and Embase databases until March 21, 2020. We only included randomized controlled trials (RCTs) comparing the efficacy of vitamin D supplementation with placebo in critically ill adult patients. The primary outcome was their 28-day mortality. Overall, 9 RCTs with 1867 patients were included. In the pooled analysis of the 9 RCTs, no significant difference was observed in 28-day mortality between the vitamin D supplementation and placebo groups (20.4% vs 21.7%, OR, 0.73; 95% CI, 0.46–1.15; I2 = 51%). This result did not change as per the method of vitamin D supplementation (enteral route only: 19.9% vs 18.2%, OR, 1.19; 95% CI, 0.88–1.57; I2 = 10%; intramuscular or intravenous injection route: 25.6% vs 40.8%, OR, 0.48; 95% CI, 0.21–1.06; I2 = 19%) or daily dose (high dose: 20.9% vs 19.8%, OR, 0.83; 95% CI, 0.51–1.36; I2 = 53%; low dose: 15.6% vs 21.3%, OR, 0.74; 95% CI, 0.32–1.68; I2 = 0%).
No significant difference was observed between the vitamin D supplementation and placebo groups regarding the length of ICU stay (standard mean difference SMD, − 0.30; 95% CI, − 0.61 to 0.01; I2 = 60%), length of hospital stay (SMD, − 0.17; 95% CI, − 041 to 0.08; I2 = 65%), and duration of mechanical ventilation (SMD, − 0.41; 95% CI, − 081 to 0.00; I2 = 72%).
In conclusion, this meta-analysis suggested that the administration of vitamin D did not provide additional advantages over placebo for critically ill patients. However, additional studies are needed to confirm our findings.
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19 Meta-analyses in Trauma-Surgery categories This list is automatically updated
- Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023
- Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023
- ICU Vitamin D supplementation not help (study ignored level achieved) – meta-analysis 2022
- Vitamin D and the Critically Ill - meta-analysis – April 2022
- Delirium or cognitive problems after surgery 1.5X more likely if low vitamin D –meta-analysis Aug 2022
- ICU mortality reduced by non-oral vitamin D – meta-analysis May 2021
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- ICU length of stay reduced when supplement with Omega-3 – meta-analysis July 2018
- Critically ill children with low vitamin D: 2.5 X more likely to die or stay 2 days longer - meta-analysis Nov 2017
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis Nov 2016
- 4 fewer days in hospital after hip or knee replacement if good level of vitamin D – June 2016
- Surgical outcomes are better for higher levels of Vitamin D – systematic review May 2015
- 1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014
- Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011
ICU Vitamin D supplementation not help (study ignored level achieved) – meta-analysis 2022Printer Friendly Follow this page for updates518 visitors, last modified 07 Dec, 2022, This page is in the following categories (# of items in each category)