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How vitamins A, B, C, D, E, F (Omega), K fight COVID - Feb 2022


Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy

European Journal of Medicinal Chemistry 232 (2022) 114175 https://doi.org/10.1016/j.ejmech.2022.114175
Aurelia Magdalena Pisoschi a’ *, Aneta Pop a, Florin Iordache a, Loredana Stanca a,
Ovidiu Ionut Geicu a, Liviu Bilteanu a’b, Andreea Iren Serban a’c

  • a University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, Department Preclinical Sciences, 105 Splaiul Independentei, 050097, Bucharest, Romania
  • b Molecular Nanotechnology Laboratory, National Institute for Research and Development in Microtechnologies, 126A, Erou Iancu Nicolae Street, 077190, Bucharest, Romania
  • c University of Bucharest, Faculty of Biology, Department Biochemistry and Molecular Biology, 91-95 Blvd, Splaiul Independentei, 050095, Bucharest, Romania


Oxidative stress is caused by an abundant generation of reactive oxygen species, associated to a diminished capacity of the endogenous systems of the organism to counteract them. Activation of prooxidative pathways and boosting of inflammatory cytokines are always encountered in viral infections, including SARS-CoV-2. So, the importance of counteracting cytokine storm in COVID-19 pathology is highly important, to hamper the immunogenic damage of the endothelium and alveolar membranes. Antioxidants prevent oxidative processes, by impeding radical species generation. It has been proved that vitamin intake lowers oxidative stress markers, alleviates cytokine storm and has a potential role in reducing disease severity, by lowering pro-inflammatory cytokines, hampering hyperinflammation and organ failure. For the approached compounds, direct antiviral roles are also discussed in this review, as these activities encompass secretion of antiviral peptides, modulation of angiotensin-converting enzyme 2 receptor expression and interaction with spike protein, inactivation of furin protease, or inhibition of pathogen replication by nucleic acid impairment induction. Vitamin administration results in beneficial effects. Nevertheless, timing, dosage and mutual influences of these micronutrients should be carefullly regarded.
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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of Jan 31, 2024, the VitaminDWiki COVID page had:  19+ trial results,   37+ meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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VitaminDWiki Virus pages with VITAMIN D in title (539 as of Feb 2022)

This list is automatically updated

Items found: 700
Title Modified
High Vitamin D may prevent or treat COVID-19 - April 23, 2020 21 May, 2020
Vitamin D trial with COVID-19 in Sri Lanka - interview May 16 18 May, 2020
Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020 15 May, 2020
Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020 14 May, 2020
UK makes a U-turn on Vitamin D and COVID-19 - a vivid imagination 09 May, 2020
Dengue virus 2X to 4X more likely if vitamin D receptor gene problems 08 May, 2020
Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020 30 Apr, 2020
COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 29 Apr, 2020
COVID-19 is harder for those with dark skins - perhaps due to low vitamin D – April 24, 2020 25 Apr, 2020
COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020 21 Apr, 2020
Many doctors believe that high dose vitamin D can fight COVID-19 – BMJ April 2020 14 Apr, 2020
COVID-19 from Rheumatology point of view (includes Vitamin D, ACE2) – April 2020 12 Apr, 2020
COVID-19 prompts awareness of deficiencies of Vitamin D, C and Magnesium - April 6 2020 08 Apr, 2020
Vitamins C and D being considered as Coronavirus Treatments - April 7, 2020 07 Apr, 2020
Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020 07 Apr, 2020
Vitamin D may be a COVID-19 Game-changer - BMJ April 6, 2020 07 Apr, 2020
COVID-19 is strongly associated with low vitamin D 05 Apr, 2020
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Vitamin D should prevent COVID-19 (recommended dose takes 3 months to raise levels) - April 2020 03 Apr, 2020
Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020 02 Apr, 2020
COVID-19 infections associated with very low vitamin D – Turin Italy – March, 2020 30 Mar, 2020
Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 30 Mar, 2020
Reduce Coronavirus risk with Vitamin D (50,000 IU once a week) 27 Mar, 2020
COVID-19 might be fought by 2 doses of Vitamin D (200,000-300,000 IU each) – Feb 2020 23 Mar, 2020
Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018 10 Mar, 2020
AI tool predicts COVID-19 test results (ignores Vitamin D, but severity is associated with HT) – March 2020 09 Mar, 2020
Immune system is fortified by micronutrients such as vitamin D – Review Jan 2020 06 Mar, 2020
Coronavirus and possible supplements (only Vitamin D might prevent)- March 2020 05 Mar, 2020
Vitamin D prevents Hepatitis-C and helps treat it (many studies) 03 Mar, 2020
Vitamin D can reduce COVID-19 risk in quarantine, etc. 27 Feb, 2020
South Koreans - half take supplements, Vitamin D levels dropping, COVID-19 21 Feb, 2020
Dr. Coimbra on Coronavirus and Vitamin D (English transcript) - Jan 2020 31 Jan, 2020
Warts removed by vitamin D injection - many studies 11 Jan, 2020
Vaccine antibody generation not change with Vitamin D – 21 ng or 44ng – RCT Feb 2019 08 Jan, 2020
Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019 26 Nov, 2019
Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019 07 Nov, 2019
Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019 06 Oct, 2019
2017 Flu in Australia was bad and 79,000 died in US, 2019 Flu in Australia was worse (get flu shot AND Vitamin D) 04 Oct, 2019
Shingles near the eyes – 3X increase in 12 years (note – Vitamin D treats shingles) – May 2019 06 Jul, 2019
Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019 15 Jun, 2019
How Vitamin D helps fight the cold, flu and other viruses - June 2019 04 Jun, 2019
The interplay between vitamin D and viral infections – Jan 2019 17 Feb, 2019
Vitamin D 10 x better than Flu Vaccine if you have very low vitamin D – Feb 2017 04 Feb, 2019
Vitamin D Workshop near Seattle - Jan 20, 2019 21 Jan, 2019
Vitamin D does not prevent all viral infections (enveloped virus not mentioned) – Jan 2019 12 Jan, 2019
Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin 06 Jan, 2019
Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018 23 Nov, 2018
Loss of smell may be related to low Zinc or perhaps low vitamin D 11 Nov, 2018
Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018 20 Oct, 2018
Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018 18 Oct, 2018
Cerebral malaria deaths prevented by loading dose of vitamin D (mice) – Sept 2018 23 Sep, 2018
Addition of Vitamin D to experimental cerebral malaria therapy cut the mouse death rate in half – Oct 2016 23 Sep, 2018
Influenza virus might be prevented and treated by Vitamin D, if no vaccination – Aug 2018 16 Aug, 2018
Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018 10 Aug, 2018
3X increase in insect-born diseases in 13 years (reduced vitamin D level not mentioned) – May 2018 10 Aug, 2018
Vitamin D Effective in Preventing Flu if not vaccinated - June 2018 04 Jul, 2018
Immunity increased by Vitamin D via cells and genes (HIV etc.) – March 2018 31 Mar, 2018
Hand, Foot, and Mouth disease (virus) strongly associated with low vitamin D – May 2017 07 Mar, 2018
Elderly Influenza deaths do not increase in winter in countries with high vitamin D levels 09 Feb, 2018
Prisoners have very low vitamin D and get TB, influenza, and depression 21 Dec, 2017
Dengue fever - 8X higher risk for getting worse if low vitamin D – Sept 2017 15 Sep, 2017
Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016 27 Jul, 2017
10X reactions to flu vaccine when vitamin D deficient 09 May, 2017
Chikungunya virus arthritis pain reduced by weekly 60,000 IU vitamin D – Sept 2016 29 Sep, 2016
Vaginal Vitamin D reduced vaginal infections - Jan 2014 26 Sep, 2016
Yet another virus associated with low vitamin D – mononucleosis – Aug 2016 10 Aug, 2016
Vitamin D Deficiency May Help Spread of Hepatitis B Throughout Liver – May 2013 23 Jul, 2016
Hepatitis B clinical event was 2X more likely if low vitamin D – Oct 2014 23 Jul, 2016
Hepatitis B virus might be treated by Vitamin D – April 2015 23 Jul, 2016
Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009 22 Jul, 2016
Infection fighting ability increased with 5,000 IU Vitamin D daily – April 2015 10 Jul, 2016
Hypothesis – Vitamin D help MicroRNAs reduce Virus Infection – April 2016 29 Jun, 2016
Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015 11 Jun, 2016
Obesity pandemic since 1975 - is it due to Vitamin D, Magnesium, Iodine, adenovirus, or what 10 Jun, 2016
Vitamin D and the anti-viral state – March 2010 05 Jun, 2016
Request for Zika and Vitamin D data - June 5, 2016 05 Jun, 2016
Zika communications gets 1.5 million dollars from Gates Foundation (still nothing for prevention by Vitamin D) – May 2016 22 May, 2016
Dengue virus infection treated by (active) Vitamin D in the lab – April 2012 20 May, 2016
Dengue, Vitamin D and microRNAs – May 2016 20 May, 2016
Prevent Zika birth defects with Vitamin D 19 May, 2016
Four antiviral strategies – includes vitamin D – Vasquez Dec 2014 19 May, 2016
Chronic hepatitis C, Vitamin D, and interferon-α – July 2015 18 May, 2016
Immune response to respiratory viruses – vitamin D connection – review May 2015 17 May, 2016
Zika slowed in mice by a Hepatitis-C drug (Vitamin D also treats Hepatitis-C) May 2016 17 May, 2016
Dengue Fever associated with poor vitamin D receptor – July 2002 01 May, 2016
Vitamin D may protect against Ebola 01 May, 2016
Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014 01 May, 2016
Adaptive immunity (cancer, viruses, autoimmune) and vitamin D – April 2016 25 Apr, 2016
CDC: Influenza vaccinations not expected to work well this year (but vitamin D should) – Dec 2014 24 Mar, 2015
Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014 31 Dec, 2014
Major interactions between Vitamin D, Vitamin A, and Influenza – Sept 2013 05 Dec, 2014
Influenzas – both seasonal and pandemic – increase in the winter (low vitamin D) – Dec 2010 07 Nov, 2014
Epidemic influenza and vitamin D – 2007 09 Oct, 2014
Influenza A: 5X reduction in first month (only) with 2,000 IU of vitamin D– RCT July 2014 14 Jul, 2014
Rotovarious virus less of a problem for pigs with enough vitamin D – CT May 2014 16 Jun, 2014
Hepatitis C drug is extremely expensive, why not try Calcidiol (semi-processed vitamin D) - May 2014 07 May, 2014
Influenza, seniors and vitamin D – Jan 2012 27 Apr, 2014
Flu Hits 14 year low, perhaps Vitamin D 02 Apr, 2012
Should seniors get a vitamin D booster shot for Influenza – Jan 2012 19 Dec, 2011
Low vitamin D then Obesity then adenovirus-36 28 Nov, 2010
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Created by admin. Last Modification: Monday February 14, 2022 09:13:47 GMT-0000 by admin. (Version 10)

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17055 Vitamin Impact.jpg admin 14 Feb, 2022 475.35 Kb 329
17054 Vitamin Intervension B.jpg admin 14 Feb, 2022 48.38 Kb 250
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17052 Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy.pdf admin 14 Feb, 2022 1.24 Mb 277