Highlights of Vitamin D Wiki

Although researchers, physicians, and clinical nutritionists can't agree completely on dose rates, recommended blood levels, and expected clinical outcomes, there is no question that vitamin D status plays an important role in reducing, preventing, and in some cases, treating a wide range of chronic degenerative medical conditions. The purpose of the VitaminDWiki is to provide a convenient, comprehensive, and authoritative resource to investigate how optimizing vitamin D status may be helpful for you or someone you care about. It's a big subject so we urge you to spend some time exploring and learning about this important nutrient.

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Vitamin D is associated with many health problems

Less sun ==> Less Vitamin D ==> Less Health (chart)

click on image for details and translation
70 Proofs that Vitamin D prevents or treats the following diseases
Hypertension, Cardiovascular, Back pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Multiple Sclerosis, Raynaud's pain, Menstrual Pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell, leg ulcers, traumatic brain injury, Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure (Infants), Middle Ear Infection (Infants), Gingivitis, stronger senior muscles, antibiotic use in seniors, short Infants, Gestational Diabetes, heart pump better after attack, Prostate Cancer, Asthma, Depression, Vitamin D in Breast Milk, Fibromyalgia, Chronic Hives, Cholesterol, COPD, Asthma, Quality of Life, Survive ICU, Restless Leg Syndrome, Hepatitis-C, Crohn's disease, Pre-term birth, Cluster headaches, Autism, PreDiabetes, Weight loss, Sarcopenia = muscle loss, Growing Pains, Osteoarthritis, ALS, Vertigo, Warts, Metabolic Syndrome, Hay fever, Preeclampsia, Blood cell cancer, Irritable Bowel Syndrome, Urinary Tract Infection, Mite Allergy, Perinatal Depression, Vaginosis, Eczema, NAFLD, Knee Osteoarthritis, Tuberculosis, Ischemic Stroke, Sepsis, Trauma Deaths, Hemodialysis, Fatty liver - child, Fatigue, Poor Sleep, Pneumonia (Ventilator-associated), Male infertility, Waist size, ADHD, Alcoholic liver cirrhosis, Diabetic nephropathy. Ulcerative Colitis. Weight loss

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Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

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6 times to 55 times more likely to get these health problems

• Many health problems associated with low vitamin D
       click to read the studies
• 55 X more likely to have bone fracture requiring surgery
• 30 X more likely for COPD becoming suddenly worse
• 25 X more likely to have senior moment
• 23 X more likely to have vertigo
• 19 X more likely to get dementia
• 17 X more likely to have muscle inflammation
• 14 X more likely to die after first cardiovascular event
• 14 X more likely for dark skinned children to get T1 diabetes
• 12 X more likely to die from elderly pneumonia
• 11 X more likely to be allergic to peanuts
• 10 X more reactions to flu vaccine
• 10 X more likely for stroke patients to become depressed
• 9 X more likely to have Gastric Cancer
• 8 X more likely to have Autoimmune Hepatitis
• 8 X more likely for alcoholic to have Alcoholic liver disease
• 8 X more likely to get lupus
• 7 X more likely to have low birth weight infant
• 7 X more likely for pregnant teen to have anemia
• 7 X more likely to have leg pain
• 7 X increased chance of death from coronary artery disease
• 6.5 X more likely for infant to be Small for Gestational Age
• 6 X worse outcome following Sudden cardiac arrest
• 6 X more likely to get hip fracture after stroke
• 6 X more likely to die after coronary bypass
• 6 X more likely to have allergic rhinitis
• 6 X more likely to get diabetes if abdominal obese
• 6 X more likely to get cancer in children

CLICK HERE for entire 3X to 55X list for more information

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Health problem - examples

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Alzheimers-Cognition

Alzheimers-Cognition - Overview has the following summary

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s 21 % more likely if low vitamin D
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition lntervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  • As of 2018 that combination has worked well with
    • Multiple Sclerosis, Sleep, and Cluster Headaches
  • Other studies concerning Omega-3 include
    • Omega-3 helped Alzheimer’s only if good level of B vitamins – RCT April 2019
    • APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018
    • Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017
•     All items in category Cognition and vitamin D 296

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Breast Cancer

Overview Breast Cancer and Vitamin D contains the following summary and sections

• 22 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 224 items along with related searches

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Breathing

Breathing category starts with the following

395 items in Breathing category

• Search VitaminDWiki for Pneumonia 1,360 items as of July 2019
• Search VitaminDWiki for phrase "COMMUNITY PNEUMONIA" 99 items - Jan 2020
• Search VitaminDWiki for BRONCHITIS 272 items as of July 2019
• Search VitaminDWiki for (asthma OR asthmatic) in title 574 items - March 2021
• COPD Overview
• Search VitaminDWiki for Wheeze 1480 items as of July 2020
• Cystic Fibrosis category listing has 42 items along with related searches
• Air Pollution reduces Vitamin D
  • Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
• Smoking reduces vitamin D
  Supplementing with Vitamin D will improve the health of smokers and might decease craving
• Overviews at VitaminDWiki:
  Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu  Pneumonia   Respiratory infections

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Cardiovascular

Cardiovascular category listing has 435 items along with related searches 435 items In Cardiovascular category

• Overview Cardiovascular and vitamin D
• Hypertension and vitamin D
• Overview Metabolic Syndrome and vitamin D
• Overview Stroke and vitamin D
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
• Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
• Heart attack ICU costs cut in half by Vitamin D – Oct 2018

Meta-analyses

• Heart Failure and Vitamin D meta-analyses - 2016, 2019
• Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
• Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018

Omega-3 Helps

• Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
• Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

• Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
• Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016

Cholesterol, Statins

• Cholesterol is needed to produce both Vitamin D and Cortisol
• Overview Cholesterol and vitamin D
• Statins and vitamin D statins often reduce levels of vitamin D
• Statin side-effects are reduced by Vitamin D – US patent Application – April 2019

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Diabetes

Overview Diabetes and vitamin D appears to be due to a lack of Vitamin D

• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 473 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• Appears that Calcium and Magnesium are needed for both Prevention and Treatment
  • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

• Dark Skin 23;   Intervention 51;   Meta-analysis 32;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 10;  Vitamin D Receptor 20;  Genetics 11;  Magnesium 19    Click here to see details

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Falls and Fractures

Falls and Fractures category contains the following summary

• 223 items in FALLS and FRACTURES
• see also Overview Seniors and Vitamin D
• Overview Fractures and Falls and Vitamin D
• Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
• Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
• Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
• Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
• Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
• Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014

Hip fracture

• Search VitaminDWiki for "HIP FRACTURE" 191 items not in PDF as of July 2020
• A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020
• Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020
• 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
• Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018
• Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
• Fracture risk 40 percent higher risk if low Vitamin D - June 2019
• 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017

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Kidney

Overview Kidney and vitamin D contains the following summary

• FACT: The Kidneys are not the primary way to activate vitamin D, the tissues are
• FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
• FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
• FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
• FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
• FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
• FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
• Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
    Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
  Calcitriol - which bypasses the need for the kidney to activate vitamin D
    Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
      Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
• Category Kidney and Vitamin D contains 202 items

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Obesity

Overview Obesity and Vitamin D contains the following summary

• FACT: People who are obese have less vitamin D in their blood
• FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
• FACT: When obese people lose weight the vitamin D level in their blood increases
• FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
• FACT: 153 trials for vitamin D intervention of obesity as of Sept 2020
• FACT: Less weight gain by senior women with > 30 ng of vitamin D
• FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
• FACT: Obese lost 3X more weight by adding $10 of Vitamin D
• FACT: Those with darker skins were more likely to be obese Sept 2014
• OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
  • and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
• SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
    risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
• Obesity category has 361 items

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Osteoporosis

Overview Osteoporosis and vitamin D contains the following summary

• FACT: Bones need Calcium (this has been known for a very long time)
• FACT: Vitamin D improves Calcium bioavailability (3X ?)
• FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
• FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
• FACT: Vitamin D supplements are very low cost
• FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
• FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
• FACT: Co-factors help build bones.
• FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
• It appears that to TREAT Osteoporosis:
•        Calcium OR vitamin D is ok
•        Calcium + vitamin D is good
•        Calcium + vitamin D + other co-factors is great
•        Low-cost Vitamin D Receptor activators sometimes may be helpful
• CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
• Category Osteoporosis has 192 items
• Category Bone Health has 277 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
Osteoporosis category includes the following

• 192 items in category - see also Overview Osteoporosis and vitamin D
• Overview Fractures and vitamin D
• Bone - Health 277 items
• Search BMD OR Bone Mineral Density 3250 results as of July 2020
• Search VitaminDWiki for OSTEOPENIA 1740 items as of July 2020
• 11 articles are in both Osteroporosis and Vitamin D Receptor categories
• 8 articles are in both Osteroporosis and Meta-analysis categories

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Pain

Pain - chronic category has the following

138 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 65 items
• "musculoskeletal pain" 374 items as of March 2018
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 39 items
• "KNEE PAIN" 121 items as of March 2018

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Parkinson’s

Overview Parkinsons and Vitamin D contains the following summary
Parkinson's Disease proven to be TREATED by Vitamin D (Many Meta-analyses of trials)

• Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT May 2013
  First RCT to report results - +anticipate far better results when more vitamin D is used.
     (Belief based on the results with vitamin D on MS and Diabetes)
  Additonal proofs that vitamin D treats or prevents diseases
• 6 clinical trials for PD with vitamin D intervention as of Jan 2016
  A person could wait a few years to get the results of the clinical trials, but
• Based on reading more than 4,000 studies of vitamin D at VitaminDWiki
• A (loading) dose of 20,000 IU of vitamin D daily for the 3 weeks should provide observable benefit
  To avoid a rare reaction to Vitamin D
  take 1,000 IU of vitamin D first, and stop if you you have an allergic reaction withiin 3 days
  When continuing to take vitamin D you should also take cofactors
  There is virtually no need have a vitamin D test in first 2 months
•    Parkinson's category has 84 items

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Schizophrenia

Overview Schizophrenia and Vitamin D contains the following summary
Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
    Click here for some details
Omega-3 may treat schizophrenia wonder if Omega-3 and Vitamin D would be additive or even synergistic

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Sports

Overview Sports and vitamin D has the following summary
Athletes are helped by vitamin D by:

1. Faster reaction time
2. Far fewer colds/flus during the winter
3. Less sore/tired after a workout
4. Fewer micro-cracks and broken bones
5. Bones which do break heal much more quickly
6. Increased VO2 and exercise endurance Feb 2011
7. Indoor athletes especially need vitamin D
8. Professional indoor athletes are starting to take vitamin D and/or use UV beds
9. Olympic athletes have used UV/vitamin D since the 1930's
10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
11. Reduced muscle fatigue with 10,000 IU vitamin D daily
12. Muscle strength improved when vitamin D added: 3 Meta-analysis
13. Reduced Concussions
    See also: Sports and Vitamin D category 238 items

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Groups typically needing more Vitamin D

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Seniors need more vitamin D - 10 reasons

1. Senior skin produces 3X less Vitamin D for the same sun intensity
2. Seniors have fewer vitamin D receptors as they age
   • (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
3. Seniors are indoors more than than when they were younger
   • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
   • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
4. Seniors wear more clothing outdoors than when younger **+fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
9. Seniors not have as much Magnesium needed to use vitamin D
   (would not show up on vitamin D test)
10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

• Category Seniors and Vitamin D 354 items

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 Infants-Child

Infant-Child category starts with

• No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
• 400 IU Vitamin D is no longer enough
  Was OK in the past century, but D levels have been dropping for a great many reasons.
  FDA doubled the vitamin D level in milk in July 2016
• No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
• Fewer infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
• 1600 IU was the conclusion of three JAMA studies
     1000 IU recommended in France and Finland – 2013 - appears to be a good level
  A recommended level may be agreed upon around the world by 2020
• 5X less mite allergy after add vitamin D
• Child bone fractures with low vitamin D were 55X more likely to need surgery
• 75 % of SIDS had low vitamin D
• Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
• 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014

Having a good level of vitamin D cuts in half the amount of:

• Asthma, Chronic illness, Doctor visits, Allergies, infection
  Respiratory Tract Infection, Growing pains, Bed wetting

Need even more IUs of vitamin D to get a good level if;

• Have little vitamin D: premie, twin, mother did not get much sun access
• Get little vitamin D: dark skin, little access to sun
• Vitamin D is consumed faster than normal due to sickness
• Older (need at least 100 IU/kilogram, far more if obese)
• Not get any vitamin D from formula (breast fed) or (fortified) milk
  Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

• Sun is great – well known for 1,000’s of years.
  US govt (1934) even said infants should be out in the sun
• One country recommended 2,000 IU daily for decades – with no known problems
• As with adults, infants and children can have loading doses and rarely need tests
• Daily dose appears to be best, but monthly seems OK
• Vitamin D is typically given to infants in the form of drops
     big difference in taste between brands
     can also use water-soluable form of vitamin D in milk, food, juice,
• Infants have evolved to get a big boost of vitamin D immediately after birth
  Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
• 100 IU per kg of infant July 2011, Poland etc.
  
  More than 100 IU/kg is probably better

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Getting Vitamin D into infants
Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

• 631 items in the category Infant/Child See also
• breastfed OR breastfeeding 1920 items as of Dec 2020
• "BIRTH DEFECTS" 172 items as of July 2016
• Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
• "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
• Overview of Rickets and Vitamin D
• Youth category listing has 151 items along with related searches

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Pregnant

Overview Pregnancy and vitamin D
Pregnancy category starts with

764 items in Pregnancy category

 - see also

• Overview Pregnancy and vitamin D
• Number of articles in both categories of Pregnancy and:
  Dark Skin 25;   Depression 18;   Diabetes 40;   Obesity 12;  Hypertension 35;   Breathing 30;  Omega-3 32;  Vitamin D Receptor 20
• All items in category Infant/Child 631 items
• breastfed OR breastfeeding 1920 items as of Dec 2020
• Preeclampsia 825 items as of Jan 2018
• Pre-term 368 items (not in PDF) as of Nov 2020
• "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
• Gestational Diabetes
• c-section OR "caesarean section" (various spellings) 937 items as of Aug 2020
• postpartum depression 208 items as of Aug 2018
• Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 794 as of Feb 2020
• Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
• Fertility and Sperm category listing has 110 items along with related searches
• (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
• Healthy pregnancies need lots of vitamin D
• Ensure a healthy pregnancy and baby - take Vitamin D before conception
  

Problem	Reduces	Evidence
0. Chance of not conceiving	3.4 times	Observe
1. Miscarriage	2.5 times	Observe
2. Pre-eclampsia	3.6 times	RCT
3. Gestational Diabetes	3 times	RCT
4. Good 2nd trimester sleep quality	3.5 times	Observe
5. Premature birth	2 times	RCT
6. C-section - unplanned	1.6 times	Observe
Stillbirth - OMEGA-3	4 times	RCT - Omega-3
7. Depression AFTER pregnancy	1.4 times	RCT
8. Small for Gestational Age	1.6 times	meta-analysis
9. Infant height, weight, head size      within normal limits		RCT
10. Childhood Wheezing	1.3 times	RCT
11. Additional child is Autistic	4 times	Intervention
12.Young adult Multiple Sclerosis	1.9 times	Observe
13. Preeclampsia in young adult	3.5 times	RCT
14. Good motor skills @ age 3	1.4 times	Observe
15. Childhood Mite allergy	5 times	RCT
16. Childhood Respiratory Tract visits	2.5 times	RCT

RCT = Randomized Controlled Trial
CLICK HERE to see entire page

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Darker Skin

• Overview Dark Skin and Vitamin D
• Dark skin births are much riskier due to lack of vitamin D
• Vitamin D deficiency diseases in dark skinned people living far from equator – Meta-analysis Oct 2013
• Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012
• Extra 4,000 IU daily raised the vitamin D levels of blacks to that of whites – July 2012
• Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
• Differences in black and non-black mortality and vitamin D – Oct 2012
• Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015

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Other High Risk Groups

High Risk of little Vitamin D category listing has 52 items and has:

• 40 percent lower vitamin D level if work other shifts (Italy) – June 2015
• Burkas reduce vitamin D levels, which causes pregnancy problems – Oct 2015
• The only supplement NASA gives crews is vitamin D - Sept 2015
• People with health problems lacking noon sun (severe Multiple Sclerosis, etc.) have even lower levels of vitamin D – March 2015
• Intellectually disabled 2X more likely to have low vitamin D (shut-in) – Sept 2014
• 4.7X less likely to feed self in nursing home if vitamin D deficient – Oct 2013

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Vitamin D supplementation

Amount of vitamin D needed vs:

More vitamin D needed -nutshell category has the following

Age	Latitude	Season
Obesity	Skin color	Avoid Sun

Supplementation from Zika book (July 20, 2016)

Vitamin D Recommendations: based on hundreds of successful Vitamin D studies (with/without pregnancy)

• 4,000 IU daily average minimum amount of Vitamin D
  Similar dosing is 50,000 IU bi-weekly (Daily is probably slightly better)
  It is 1/3 the cost and easier to remember than daily dosing.
  Note: Taking vitamin D also increases chance of pregnancy
• More is needed if likely to have very low levels of vitamin D:
  6,000 IU daily average if:
  • having twins or had a recent birth,
  • health problems associated with low vitamin D
  • indoors a lot or avoid the sun
  • dark skin
  
  10,000 IU (50,000 IU every 5th day) if:
  • Obese

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 obesity study

• if diseases run in the family
• May want to restore levels as quickly as possible with 350,000 IU loading dose
  during pregnancy, especially if there is the threat of Zika
  this gets a strong immune system quickly, not with months of delay using a daily maintenance dose
  • 50,000 IU daily for 1 week if not pregnant
  • 50,000 IU every second day for 2 weeks if pregnant
• Start ASAP during pregnancy (even before) so as to both avoid Zika and have healthy pregnancy and infant
• Should use a vitamin D which has no known adverse affects
  No additives, no oils (30% of oil-based Vit D which restrict vitamin D adsorption)
• Most people (80%?) can take regular vitamin D capsules
  Options if:
  • Not want to take pills – use liquid Vitamin D or pour vitamin D powder from capsule into food/drink
  • Poor gut – several “gut friend” forms are available
  • Vegan – several forms of Vitamin D3 are made from plants such as lichen
  • Halal, Kosher, etc.
• Magnesium Cofactor 100+ miligrams of element daily – tell why especially during pregnancy
  • Increases the benefits of vitamin D
  • Decreases chance of allergic-type reaction to Vitamin D (from ~ 3 in 1000 to 1 in 1000)
• Omega-3 Cofactor
• Vitamin K2 cofactor
• Test for Vitamin D is nice but very expensive ($60) and not really essential
• Take vitamin D just after evening meal
  • about~30% more benefit with evening meal, but most anytime is OK
• Just concerned about average vitamin D during a 2 week time period
  4,000 IU taken daily is virtually identical to 50,000 IU once every two weeks
  OK to have missed your dose for a few days - just take nissed once all at once.

How often should I take 50,000 IU

How often should I take 50000 IU (1.25 mg) of vitamin D

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10 minutes of sun not enough

No – 10 minutes per day of sun-UVB is NOT enough

• 5-10 minutes provides only 1,000 IU ONLY IF you are near the equator
• AND young
•  AND not obese
•   AND have light skin
•    AND it is summer
•     AND it is the middle of the day
•      AND you have lots of skin exposed to the sun
•       AND you are lying down
•        AND you are not wearing sunscreen
•         AND you have a healthy Liver
•          AND no clouds and nor air pollution
•           AND you have good response to sunshine (4X variation between individuals)

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Loading Dose - to get the benefit as soon as possible

Overview Loading of vitamin D contains the following

Loading dose: 167 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

• Loading = restore = quick replacement by 1 or more doses
• Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • = 2.5 to 25 milligrams
• The size of the loading dose is a function of body weight - see below
  • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
• Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
  • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
• Loading is typically oral, but can be Injection (I.M,) and Topical
• Loading dose is ~3X faster if done topically or swished inside of the mouth
  • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
• The loading dose persists in the body for 1 - 3 months
  • The loading dose should be followed up with on-going maintenance dosing
  • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
• About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
  • it appears prudent to test with a small amount of vitamin D before giving a loading dose
  • The causes of a mild allergic reaction appear to be: (in order of occurrence)
  • 1) lack of magnesium - which can be easily added
  • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
  • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
  • 4) allergy of the gut to Vitamin D - alternative = topical

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Toxicity is rare

Overview Toxicity of vitamin D

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Free Vitamin D evaluation service

Free Vitamin D evaluation service had the following questions
Positive answers indicates a possible vitamin D deficiency

• At night, I ...... have a cold feeling ... have legs that hurt ... have a restless sleep ... wake up suddenly
• During the day, I am...... listless ... tired ... lethargic ... uninspired
• I feel cramps or twitches...... in the leg ... in the arm ... in the hand ... in the eyelid
• I get dizzy...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• I feel sick...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• My head hurts or I feel pressure in my head...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• If I stand or work for an extended period of time, it hurts...... in my neck ... in my lower back ... in the groin ... in the feet
• The Sun at noon causes...... circulatory problems ... headaches ... an itching skin ... red spots
• I repeatedly have...... cold hands ... cold feet ... cold legs ... white fingertips
• My fingernails have…   number of white spots

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Cofactors are important if you take a lot of vitamin D for a long time

Vitamin D Cofactors in a nutshell
!!!!Cofactors need to be adjusted when taking a lot of vitamin D for more than a month
"A lot" is more than 4,000 IU Vitamin D daily (average)
There is virtually no agreement as how much of each cofactor is needed vs vitamin D level
The first three cofactors have, like vitamin D, greatly decreased in the human diet in the past 50 years
The goal is to restore Vitamin D, Magnesium, Omega-3, and Vitamin K back to where they had been
   in a nutshell = summed up = condensed

Supplements categories in VitaminDWiki include

Supplement	# of studies		Increase D to tissue
Omega-3	335	Many benefits	30%?
Magnesium	266	Many need Mg	30%
Calcium	197	Reduce
Vitamin K	129	Hard bones, soft arteries
Iron	56
Vitamin B12	47
Zinc	58		?%
Boron	30		+20%
Iodine	26
Resveratrol	37		>100% if poor VDR
Curcumin	10		? ?% if poor VDR

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Magnesium

• About 1 in 300 people have a poor reaction to increasing Vitamin D
     but the Vitamin D reaction (muscle pain) is almost always due to lack of Magnesium
• Magnesium increases the benefits of vitamin D by about 30% (Mg and Vit. D are synergistic)
• Magnesium provides a great many health benefits independent of Vitamin D
  • Magnesium is used at 8 stages of Vitamin D metabolism
• 100 milligrams of Magnesium (say from Magnesium Chloride) seems to be enough, even with high levels of vitamin D
  Some people (not a consensus) believe that only 100 mg of Mg can be taken up by the gut at a time
  If possible, take your Magnesium several times during the day - not just once
  • Vitamin D appears to consume Magnesium
  • People with > 100 ng of Vitamin D (and do not supplement with Mg) are 2.5X more likely to have A-fib
  • Constipation due to low Magnesium after greatly increasing Vitamin D level (personal experience of founder of VitaminDWiki)
• Overview Magnesium     Magnesium category has 266 items

Omega-3

• Omega-3 increases active vitamin D - especially in people with poorly functioning livers or kidneys
• 1 gram of Omega-3 seems to be enough. Note: different brands have widely different bio-availability
• Overview Omega-3     Omega-3 category has 335 items

Vitamin K2

• K2 Keeps Calcium in bones and out of arteries
• Calcification due to K2 deficiency may be a reason for increased mortality for some diseases for high vitamin D
• Probably need 100 micrograms per 2,000 IU of vitamin D (i.e. 500 micrograms for 10,000 IU of Vit D)
  • Perhaps Vitamin D consumes Vitamin K, so need more of it
• Vitamin D decreases the uptake of Vitamin K1 by 50%
  • Perhaps should not take K2 concurrently with Vitamin D.
• Overview Vitamin K2     Vitamin K category has 129 items

Calcium

• Too much Calcium is associated with cardiovascular problems years later, not stronger bones
• Should have less than 750 milligrams of Calcium supplementation
• Drinking a lot of water helps flush any excess Calcium from the Kidneys
• Overview Calcium     Calcium category has 197 items

Boron - good, but not as essential

• Boron increases Vitamin D and Magnesium in the body by ~ 20%
• Most people Boron deficient now that commercial fertilizers are used
• Should have 3-10 milligrams of Boron element daily
• Boron can be extremely low cost, less than $0.01 a day
• Boron category has 30 items

Zinc - good, but not as essential

• Extra Zinc does not appear to increase D in the blood. but may increase D in the tissue
• Zinc is, however, essential to make Vitamin D Receptors and utilize Omega-3
• Low zinc is associated with many autoimmune diseases,infections, colds, etc
• Zinc, like Boron, is extremly low-cost and safe
• Zinc category has 58 items

Unfortunately cofactors as pills are costly and typically need to be taken daily

• The cost of cofactors is 10X to 100X more than the vitamin D when taken as pills
• Bulk supplementation of Vitamin D, Magnesium, Zinc, B-12, K2, Boron etc. - lower cost and easier than pills
  • just 40 cents per day as a powder
• Many of the cofactors need be taken daily (vs Vitamin D can be taken weekly or bi-weekly)

Perspective of the importance of Vit D and co-factors to health

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See also VitaminDWiki

• Need to adjust cofactors if take 50,000 IU of vitamin D weekly – Nov 2013
• How you might double your response to vitamin D
  • primarliy by increasing Magnesium, Boron, Vitamin K, Omega-3
• Too much Vitamin D long-term problems if take too much vitamin D without balancing cofactors
• Low cost cofactors for vitamin D - includes listing of what the founder of VitaminDWiki actually takes
• Supplements category listing has 98 items
  • Includes mortaity problems with >400 IU of Vitamin E
• Immune system is better fortified by nano forms of Vitamin D, Vit C, Vit B12, Omega-3, resveratrol, etc - March 2021
  • many of the vitamin D cofactors are available in nano forms
• Dr. Ames triage theory - Vit D, Mg, etc immediate needs reduce their use for long term needs such as DNA repair
• Vitamin D Receptor is one of the genes which can block vitamin D from getting to the cells
  • The standard Vitamin D test cannot detect a poor Vitamin D Receptor
  • Adding more Vit D, Mg, Omega-3, Boron, Resveratrol, Zinc, etc increases Vit D getting into the cells

See also web

• Supplement reviews by ConsumerLab – Vitamin D, Magnesium, Vitamin K, Calcium , Boron – Nov 2019
• Examine.com

short URL = is.gd/Dplus

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Genes can restrict Vitamin D from getting to the cells

Even if vitamin D levels are OD (e.g. > 40 nanogram)
Genetics category listing contains the following

273 articles in the Genetics category

see also

• 394 articles in Vitamin D Receptor
• 143 articles in Vitamin D Binding Protein = GC
• 35 articles in CYP27B1
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• Getting Vitamin D into your body

Vitamin D blood test misses a lot

• Snapshot of the literature by VitaminDWiki as of early 2019
• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
•    Commercially available 2019
  • However test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
  • especially if it is one of 51+ diseases related to Vitamin D Receptor
  
  2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
  3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
  • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
  
  4) Back Pain
  • probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
    • The founder of VitaminDWiki took action with clues #3&4

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Additional Vitamin D information

   from Increased visibility for VitaminDWiki pages

VitaminDWiki page	Comment
Does Less Sun mean More Disease	5 minute video summary
Some people have problems with vitamin D	Typically low Magnesium
One pill every two weeks gives you all the vitamin D most adults need	50,000 IU every 2 weeks
Vitamin D bulb for use in the home - or perhaps office
Vitamin D from low-cost UVB lamps
Hearing Loss appears to be prevented and treated with vitamin D
Vitamin D reduces hair loss
Headache with vitamin D may mean you need Magnesium
60,000 IU vitamin D weekly with daily Calcium was safe but not enough in the winter – 2012
Vitamins To Speed Up Metabolism And Aid Weight Loss – May 2011
Low cost vitamin D Blood Tests
Gallbladder removal and vitamin D deficiency	If Gallbladder has been removed must take some other form of Vit D Water soluable, etc.
Many reasons why vitamin D deficiency has become epidemic	35 reasons, 20 are new during the past 40 years
Intervention - Vitamin D	270 Vitamin D intervention studies
Diseases which are related due to vitamin D deficiency
Reasons for low response to vitamin D
Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015	Example of huge Return On Investements
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D)	"It is difficult to get a man to understand something when his salary is dependent upon his not understanding it"

Shorturl = http://is.gd/VitDisgd (Vitamin D Is Good)