Although researchers, physicians, and clinical nutritionists can't agree completely on dose rates, recommended blood levels, and expected clinical outcomes, there is no question that vitamin D status plays an important role in reducing, preventing, and in some cases, treating a wide range of chronic degenerative medical conditions. The purpose of the VitaminDWiki is to provide a convenient, comprehensive, and authoritative resource to investigate how optimizing vitamin D status may be helpful for you or someone you care about. It's a big subject so we urge you to spend some time exploring and learning about this important nutrient.

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Vitamin D is associated with many health problems

Less sun ==> Less Vitamin D ==> Less Health (chart)

click on image for details and translation
70 Proofs that Vitamin D prevents or treats the following diseases

Hypertension, Cardiovascular, Back pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Multiple Sclerosis, Raynaud's pain, Menstrual Pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell, leg ulcers, traumatic brain injury, Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure (Infants), Middle Ear Infection (Infants), Gingivitis, stronger senior muscles, antibiotic use in seniors, short Infants, Gestational Diabetes, heart pump better after attack, Prostate Cancer, Asthma, Depression, Vitamin D in Breast Milk, Fibromyalgia, Chronic Hives, Cholesterol, Weight loss, COPD, Asthma, Quality of Life, Survive ICU, Restless Leg Syndrome, Hepatitis-C, Crohn's disease, Pre-term birth, Lupus, Cluster headaches, Autism, PreDiabetes, Weight loss, Sarcopenia = muscle loss, Growing Pains, Osteoarthritis, ALS, Vertigo, Warts, Metabolic Syndrome, Hay fever, Preeclampsia, Blood cell cancer, Irritable Bowel Syndrome, Urinary Tract Infection, Mite Allergy, Perinatal Depression, Vaginosis, Eczema, NAFLD, Knee Osteoarthritis, Tuberculosis, Ischemic Stroke, Sepsis, Trauma Deaths, Hemodialysis, Fatty liver - child, Fatigue, Poor Sleep, Pneumonia (Ventilator-associated), Male infertility, Waist size, ADHD

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6 times to 55 times more likely to get these health problems

• Many health problems associated with low vitamin D
       click to read the studies
• 55 X more likely to have bone fracture requiring surgery
• 30 X more likely for COPD becoming suddenly worse
• 25 X more likely to have senior moment
• 23 X more likely to have vertigo
• 19 X more likely to get dementia
• 17 X more likely to have muscle inflammation
• 14 X more likely to die after first cardiovascular event
• 14 X more likely for dark skinned children to get T1 diabetes
• 12 X more likely to die from elderly pneumonia
• 11 X more likely to be allergic to peanuts
• 10 X more reactions to flu vaccine
• 10 X more likely for stroke patients to become depressed
• 9 X more likely to have Gastric Cancer
• 8 X more likely to have Autoimmune Hepatitis
• 8 X more likely for alcoholic to have Alcoholic liver disease
• 8 X more likely to get lupus
• 7 X more likely to have low birth weight infant
• 7 X more likely for pregnant teen to have anemia
• 7 X more likely to have leg pain
• 7 X increased chance of death from coronary artery disease
• 6.5 X more likely for infant to be Small for Gestational Age
• 6 X worse outcome following Sudden cardiac arrest
• 6 X more likely to get hip fracture after stroke
• 6 X more likely to die after coronary bypass
• 6 X more likely to have allergic rhinitis
• 6 X more likely to get diabetes if abdominal obese
• 6 X more likelihood of cancer in children

CLICK HERE for entire 3X to 55X list for more information

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Health problem - examples

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Alzheimers-Cognition

Alzheimers-Cognition - Overview has the following summary

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s 21 % more likely if low vitamin D
• FACT: Alzheimer's Disease is 4X less likely if less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Several vitamin D lNTERVENTION clinical trials - 64 as of Oct 2017
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should start taking vitamin D
  Additional supplements to be considered include Omega-3 and Magnesium
•     All items in category Cognition and vitamin D 212

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Breast Cancer

Overview Breast Cancer and Vitamin D contains the following summary and sections

• 16+ meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 181 items along with related searches

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Breathing

Breathing category starts with the following

305 items in Breathing category

• Search VitaminDWiki for "Respiratory Tract Infection" 482 items as of Sept 2017
  • Vitamin D Council review of RTI and Vitamin D April 2014
• Search VitaminDWiki for Pneumoma 521 items as of Oct 2017
  • Pneumonia review by Vitamin D Council May 2014
  • Search VitaminDWiki for both words: community pneumonia 117 items - Jan 2017
• Search VitaminDWiki for ASTHMA in title 640 items - July 2017
• COPD helped by weekly 50,000 IU Vitamin D – several trials
• Search VitaminDWiki for Wheeze 285 items as of Jan 2017
• Search VitaminDWiki for "air pollution" 554 items as of May 2018
• Cystic Fibrosis category listing has 28 items along with related searches
• Air Pollution reduces Vitamin D
  Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
• Smoking reduces vitamin D
  Supplementing with Vitamin D will improve the health of smokers and might decease craving
• Overviews at VitaminDWiki: Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu  Pneumonia   Respiratory infections

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Cardiovascular

Cardiovascular category listing has 371 items along with related searches 371 items In Cardiovascular category

• Overview Cardiovascular and vitamin D
• Hypertension and vitamin D
• Overview Metabolic Syndrome and vitamin D
• Overview Stroke and vitamin D
• Heart Attack 647 items as of May 2018
• Arrhythmia OR “atrial fibrillation” 497 items as of May 2018
• (Arrhythmia OR “atrial fibrillation”) AND Magnesium 345 items as of May 2018
• "C-Reactive Protein" 992 items as of May 2018
• TRIGLYCERIDES 863 items as of May 2018
• "Peripheral Artery Disease" 81 items as of Oct 2017
• "Sudden Cardiac Arrest" 98 items as of May 2018
• Search VitaminDWiki for CHF or "HEART FAILURE" 1220 items as of Aug 2017
• Search VitaminDWiki for Atherosclerosis 726 items as of Oct 2017
• Cholesterol is needed to produce both Vitamin D and Cortisol
• Overview Cholesterol and vitamin D
• Statins and vitamin D statins often reduce levels of vitamin D

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Diabetes

Overview Diabetes and vitamin D appears to be due to a lack of Vitamin D

• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 369 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• Appears that Calcium and Magnesium are needed for both Prevention and Treatment
      which are just some of the vitamin D cofactors

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Falls and Fractures

Falls and Fractures category contains the following summary

• 182 items in FALLS and FRACTURES
• see also Overview Seniors and Vitamin D
• Overview Fractures and Falls and Vitamin D
• Search VitaminDWiki for "HIP FRACTURE" 823 items as of April 2017

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Kidney

Overview Kidney and vitamin D contains the following summary

• FACT: Kidney is the primary way to activate vitamin D
• FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
• FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
• FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
• FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
• FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
• Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
    Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
  Calcitriol - which bypasses the need for the kidney to activate vitamin D
    Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
      Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
• Category Kidney and Vitamin D contains 169 items

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Obesity

Overview Obesity and Vitamin D contains the following summary

• FACT: People who are obese have less vitamin D in their blood
• FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
• FACT: When obese people lose weight the vitamin D level in their blood increases
• FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
• FACT: 126 trials for vitamin D intervention of obesity as of Dec 2017
• FACT: Less weight gain by senior women with > 30 ng of vitamin D
• FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
• FACT: Those with darker skins were more likely to be obese Sept 2014
• SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
    risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
• Obesity category has 289 items

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Osteoporosis

Overview Osteoporosis and vitamin D contains the following summary

• FACT: Bones need Calcium (this has been known for a very long time)
• FACT: Vitamin D improves Calcium bioavailability (3X ?)
• FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
• FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
• FACT: Vitamin D supplements are very low cost
• FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
• FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
• FACT: Co-factors help build bones.
• It appears that to TREAT Osteoporosis:
•        Calcium OR vitamin D is ok
•        Calcium + vitamin D is good
•        Calcium + vitamin D + other co-factors is great
• CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
• Category Osteoporosis has 161 items
• Category Bone Health has 232 items

Osteoporosis category includes the following

• 161 items in category - see also Overview Osteoporosis and vitamin D
• Overview Fractures and vitamin D
• Bone - Health 232 items
• Search BMD OR Bone Mineral Density 2240 results as of May 2018
• Search VitaminDWiki for OSTEOPENIA 808 items as of May 2018

Pages in BOTH the categories Osteoporosis and Meta-analysis

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Pain

Pain - chronic category has the following

116 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 51 items
• "musculoskeletal pain" 374 items as of March 2018
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 24 items
• "KNEE PAIN" 121 items as of March 2018

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Parkinson’s

Overview Parkinsons and Vitamin D contains the following summary

Parkinson's Disease proven to be TREATED by Vitamin D (RCT)

• Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT May 2013
  First RCT to report results - +anticipate far better results when more vitamin D is used.
     (Belief based on the results with vitamin D on MS and Diabetes)
  Additonal proofs that vitamin D treats or prevents diseases
• 6 clinical trials for PD with vitamin D intervention as of Jan 2016
  A person could wait a few years to get the results of the clinical trials, but
• Based on reading more than 4,000 studies of vitamin D at VitaminDWiki
• A (loading) dose of 20,000 IU of vitamin D daily for the 3 weeks should provide observable benefit
  To avoid a rare reaction to Vitamin D
  take 1,000 IU of vitamin D first, and stop if you you have an allergic reaction withiin 3 days
  When continuing to take vitamin D you should also take cofactors
  There is virtually no need have a vitamin D test in first 2 months
•    Parkinson;s category has 70 items

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Schizophrenia

Overview Schizophrenia and Vitamin D contains the following summary

Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
    Click here for some details
Omega-3 may treat schizophrenia wonder if Omega-3 and Vitamin D would be additive or even synergistic

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Sports

Overview Sports and vitamin D has the following summary

Athletes are helped by vitamin D by:

1. Faster reaction time
2. Far fewer colds/flus during the winter
3. Less sore/tired after a workout
4. Fewer micro-cracks and broken bones
5. Bones which do break heal much more quickly
6. Increased VO2 and exercise endurance Feb 2011
7. Indoor athletes especially need vitamin D
8. Professional indoor athletes are starting to supplement with vitamin D or use vitamin D beds
9. Olympic athletes have used UV/vitamin D since the 1930's
10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
11. Reduced muscle fatigue with 10,000 IU vitamin D daily
12. Muscle strength improved when vitamin D added: 3 Meta-analysis

• Sports and Vitamin D category 183 items

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Groups typically needing more Vitamin D

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Seniors need more vitamin D - 10 reasons

1. Senior skin produces 3X less Vitamin D for the same sun intensity
2. Seniors have fewer vitamin D receptors as they age
   (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
3. Seniors are indoors more than when when they were younger
   not as agile, weaker muscles; frail, no longer enjoy hot temperatures
   (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
4. Seniors wear more clothing outdoors than when younger
   fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test)
   statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
9. Seniors not have as much Magnesium needed to use vitamin D
   (would not show up on vitamin D test)
10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test)
    2009 full text online  Also PDF 2009
11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

• Category Seniors and Vitamin D 275 items

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 Infants-Child

Infant-Child category starts with

• No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
• 400 IU Vitamin D is no longer enough
  Was OK in the past century, but D levels have been dropping for a great many reasons.
  FDA doubled the vitamin D level in milk in July 2016
• No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
• Fewer infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
• 1600 IU was the conclusion of three JAMA studies
     1000 IU recommended in France and Finland – 2013 - appears to be a good level
  A recommended level may be agreed upon around the world by 2020
• 5X less mite allergy after add vitamin D
• Child bone fractures with low vitamin D were 55X more likely to need surgery
• 75 % of SIDS had low vitamin D
• Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
• 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014

Having a good level of vitamin D cuts in half the amount of:

• Asthma, Chronic illness, Doctor visits, Allergies, infection
  Respiratory Tract Infection, Growing pains, Bed wetting

Need even more IUs of vitamin D to get a good level if;

• Have little vitamin D: premie, twin, mother did not get much sun access
• Get little vitamin D: dark skin, little access to sun
• Vitamin D is consumed faster than normal due to sickness
• Older (need at least 100 IU/kilogram, far more if obese)
• Not get any vitamin D from formula (breast fed) or (fortified) milk
  Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

• Sun is great – well known for 1,000’s of years.
  US govt (1934) even said infants should be out in the sun
• One country recommended 2,000 IU daily for decades – with no known problems
• As with adults, infants and children can have loading doses and rarely need tests
• Daily dose appears to be best, but monthly seems OK
• Vitamin D is typically given to infants in the form of drops
     big difference in taste between brands
     can also use water-soluable form of vitamin D in milk, food, juice,
• Infants have evolved to get a big boost of vitamin D immediately after birth
  Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
• 100 IU per kg of infant July 2011, Poland etc.
  
  More than 100 IU/kg is probably better

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Getting Vitamin D into infants

Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

• 439 items in the category Infant/Child See also
• breastfed 962 items as of Sept 2017
• "BIRTH DEFECTS" 172 items as of July 2016
• Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1703 items as of May 2018
• "SUDDEN INFANT DEATH" OR SIDS 133 items as of May 2018
• Overview of Rickets and Vitamin D
• Youth category listing has 126 items along with related searches

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Pregnant

Overview Pregnancy and vitamin D
Pregnancy category starts with

605 items in Pregnancy category

 - see also

• Overview Pregnancy and vitamin D
• Healthy pregnancies need lots of vitamin D
• Dark skin births are much riskier due to lack of vitamin D,
• All items in category Infant/Child 439 items
• breastfed 887 items as of Jan 2018
• Preeclampsia 825 items as of Jan 2018
• Pre-term 2110 items as of Feb 2017
• "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
• Gestational Diabetes
• c-section OR "caesarean section" (various spellings) 242 items as of Feb 2017
• postpartum depression 129 items as of Jan 2018
• Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 541 as of June 2018
• Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
• Fertility and Sperm category listing has 84 items along with related searches
• (Stunting OR “low birth weight” OR LBW) 505 items as of Jan 2018

• Click on chart for details

Problem	Reduces	Proof
1. Miscarriage	2.5 times	Observe
2. Pre-eclampsia	3.6 times	RCT*
3. Gestational Diabetes	3 times	RCT*
4. Good 2nd trimester sleep quality	3.5 times	Observe
5. Premature birth	2 times	RCT*
6. C-section - unplanned	1.6 times	Observe
7. Depression AFTER pregnancy	1.4 times	RCT*
8. Small for Gestational Age	1.6 times	meta-analysis
9. Infant height, weight, head size      within normal limits		RCT*
10. Childhood Wheezing	1.3 times	RCT*
11. Additional child is Autistic	4 times	Intervention
12.Young adult Multiple Sclerosis	1.9 times	Observe
13. Preeclampsia in young adult	3.5 times	RCT*
14. Good motor skills @ age 3	1.4 times	Observe
15. Childhood Mite allergy	5 times	RCT*
16. Childhood Respiratory Tract visits	2.5 times	RCT*

CLICK HERE to see entire page

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Darker Skin

• Overview Dark Skin and Vitamin D
• Dark skin births are much riskier due to lack of vitamin D
• Vitamin D deficiency diseases in dark skinned people living far from equator – Meta-analysis Oct 2013
• Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012
• Extra 4,000 IU daily raised the vitamin D levels of blacks to that of whites – July 2012
• Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
• Differences in black and non-black mortality and vitamin D – Oct 2012
• Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015

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Other High Risk Groups

High Risk of little Vitamin D category listing has 38 items and has:

• 40 percent lower vitamin D level if work other shifts (Italy) – June 2015
• Burkas reduce vitamin D levels, which causes pregnancy problems – Oct 2015
• The only supplement NASA gives crews is vitamin D - Sept 2015
• People with health problems lacking noon sun (severe Multiple Sclerosis, etc.) have even lower levels of vitamin D – March 2015
• Intellectually disabled 2X more likely to have low vitamin D (shut-in) – Sept 2014
• 4.7X less likely to feed self in nursing home if vitamin D deficient – Oct 2013

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Vitamin D supplementation

Amount of vitamin D needed vs:

More vitamin D needed -nutshell category has the following

Age	Latitude	Season
Obesity	Skin color	Avoid Sun

Supplementation from Zika book (July 20, 2016)

Vitamin D Recommendations: based on hundreds of successful Vitamin D studies (with/without pregnancy)

• 4,000 IU daily average minimum amount of Vitamin D
  Similar dosing is 50,000 IU bi-weekly (Daily is probably slightly better)
  It is 1/3 the cost and easier to remember than daily dosing.
  Note: Taking vitamin D also increases chance of pregnancy
• More is needed if likely to have very low levels of vitamin D:
  6,000 IU daily average if:
  • having twins or had a recent birth,
  • health problems associated with low vitamin D
  • indoors a lot or avoid the sun
  • dark skin
  
  10,000 IU (50,000 IU every 5th day) if:
  • Obese

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 obesity study

• if diseases run in the family
• May want to restore levels as quickly as possible with 350,000 IU loading dose
  during pregnancy, especially if there is the threat of Zika
  this gets a strong immune system quickly, not with months of delay using a daily maintenance dose
  • 50,000 IU daily for 1 week if not pregnant
  • 50,000 IU every second day for 2 weeks if pregnant
• Start ASAP during pregnancy (even before) so as to both avoid Zika and have healthy pregnancy and infant
• Should use a vitamin D which has no known adverse affects
  No additives, no oils (30% of oil-based Vit D which restrict vitamin D adsorption)
• Most people (80%?) can take regular vitamin D capsules
  Options if:
  • Not want to take pills – use liquid Vitamin D or pour vitamin D powder from capsule into food/drink
  • Poor gut – several “gut friend” forms are available
  • Vegan – several forms of Vitamin D3 are made from plants such as lichen
  • Halal, Kosher, etc.
• Magnesium Cofactor 100+ miligrams of element daily – tell why especially during pregnancy
  • Increases the benefits of vitamin D
  • Decreases chance of allergic-type reaction to Vitamin D (from ~ 3 in 1000 to 1 in 1000)
• Omega-3 Cofactor
• Vitamin K2 cofactor
• Test for Vitamin D is nice but very expensive ($60) and not really essential
• Take vitamin D just after evening meal
  • about~30% more benefit with evening meal, but most anytime is OK
• Just concerned about average vitamin D during a 2 week time period
  4,000 IU taken daily is virtually identical to 50,000 IU once every two weeks
  OK to have missed your dose for a few days - just take nissed once all at once.

How often should I take 50,000 IU

How often should I take 50000 IU (1.25 mg) of vitamin D

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10 minutes of sun not enough

No – 10 minutes per day of sun-UVB is NOT enough

• 5-10 minutes provides only 1,000 IU ONLY IF you are near the equator
• AND young
•   AND not obese
•      AND have light skin
•       AND it is summer
•         AND it is the middle of the day
•           AND you have lots of skin exposed to the sun
•             AND you are lying down
•               AND you are not wearing sunscreen.
•                 AND you have a healthy Liver

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Loading Dose - to get the benefit as soon as possible

Overview Loading of vitamin D contains the following

If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically given

• Loading = repletion = quick replacement (previously known as Stoss)
• Loading doses range in size from 100,000 IU to 1,000,000 IU of Vitamin D3
• The size of the loading dose is a function of body weight - see below
  Unfortunately, some doctors persist in using Vitamin D2 instead of D3
• Loading may be done as quickly as a single day, to as slowly as 3 months.
  It appears that spreading the loading dose over 4-20 days is a good compromise
• Loading is typically oral, but sometimes by injection (I.M,)
• The loading dose persists in the body for about 3 months
  The loading dose should be followed up with continuing maintenance
  Unfortunately, many doctors fail to follow-up with the maintenance dosing.
• As about 1 in 300 people have some form of mild allergic reaction to vitamin D supplements,
  it appears prudent to test with a small amount of vitamin D before giving a loading dose
• The causes of a mild allergic reaction appear to be: (in order of occurance)
  1) lack of magnesium - which can be easily added
  2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
  3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )

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Toxicity is rare

Overview Toxicity of vitamin D

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Free Vitamin D evaluation service

Free Vitamin D evaluation service had the following questions
Positive answers indicates a possible vitamin D deficiency

• At night, I ...... have a cold feeling ... have legs that hurt ... have a restless sleep ... wake up suddenly
• During the day, I am...... listless ... tired ... lethargic ... uninspired
• I feel cramps or twitches...... in the leg ... in the arm ... in the hand ... in the eyelid
• I get dizzy...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• I feel sick...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• My head hurts or I feel pressure in my head...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• If I stand or work for an extended period of time, it hurts...... in my neck ... in my lower back ... in the groin ... in the feet
• The Sun at noon causes...... circulatory problems ... headaches ... an itching skin ... red spots
• I repeatedly have...... cold hands ... cold feet ... cold legs ... white fingertips
• My fingernails have…   number of white spots

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Cofactors are important if you take a lot of vitamin D for a long time

Vitamin D Cofactors in a nutshell

Cofactors need to be adjusted when taking a lot of vitamin D for more than a month
"A lot" is more than 4,000 IU Vitamin D daily (average)
There is virtually no agreement as how much of each cofactor is needed vs vitamin D level
The first three cofactors have, like vitamin D, greatly decreased in the human diet in the past 50 years
The goal is to restore Vitamin D, Magnesium, Omega-3, and Vitamin K back to where they had been
   in a nutshell = summed up = condensed

Magnesium

• Only about 1 in 300 people seem to be allergic to Vitamin D
     but the allergic reaction is often due to lack of Magnesium
• Magnesium increases the benefits of vitamin D by about 30% (Mg and Vit. D are synergistic)
• Magnesium provides a great many health benefits independent of Vitamin D
• 100 milligrams of Magnesium (say from Magnesium Chloride) seems to be enough, even with high levels of vitamin D
      see Overview Magnesium   Magnesium category has 198 items

Omega-3

• Omega-3 increases active vitamin D - especially in people with poorly functioning livers or kidneys
• 1 gram of Omega-3 seems to be enough. Note: different brands have widely different bio-availability
  I prefer Vetomega brand
• - see Overview Omega-3  Omega-3 category has 210 items

Vitamin K2

• K2 Keeps Calcium in bones and out of arteries
• Calcification due to K2 deficiency may be a reason for increased mortality for some diseases for high vitamin D
• Perhaps 100 micrograms per 2,000 IU of vitamin D (i.e. 500 micrograms for 10,000 IU of Vit D)
• Perhaps should not take K2 concurrently with Vitamin D. Vitamin D decreases the uptake of Vitamin K1 by 50%
• - see Overview Vitamin K2   Vitamin K category has 90 items

Calcium

• Too much Calcium is associated with cardiovascular problems years later, not stronger bones
• Should have less than 750 milligrams of Calcium supplementation
• Drinking a lot of water helps flush any excess Calcium from the Kidneys
• - see Overview Calcium   Calcium category has 170 items

Boron - good, but not as essential

• Boron increases Vitamin D and Magnesium in the body by ~ 20%
• Most people Boron deficient now that commercial fertilizers are used
• Should have 3-10 milligrams of Boron element daily
• Boron can be extremely low cost, less than $0.01 a day
• - see Boron category has 20 items

Unfortunately

• The cost of cofactors is 10X to 100X more than the vitamin D
• Many of the cofactors must be taken daily (vs bi-weekly for Vitamin D)

See also VitaminDWiki

• Too much Vitamin D long-term problems if take too much vitamin D without balancing cofactors
• Low cost cofactors for vitamin D - includes listing of what the founder of VitaminDWiki actually takes
• Supplements category listing has 76 items along with related searches
• Vitamin D Receptor is one of the genes which can block vitamin D from getting to the cells
     The standard Vitamin D test cannot detect a poor Vitamin D Receptor
     Adding more Vit D, Mg, Omega-3, Boron?, Resveratrol, etc increase Vit D to the cells

See also web
Excellent information on virtually all supplements as well as Vitamin D

• ConsumerLabs $42/year - has a 5 day free trial. lower cost for 2 year subscription
• Examine.com

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Genes can restrict Vitamin D from getting to the cells

Even if vitamin D levels are OD (e.g. > 40 nanogram)
Genetics category listing contains the following

213 articles in Genetics the category

 

see also 209 articles in Vitamin D Receptor, 85 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot

• Snapshot of the literature by VitaminDWiki - (subject to many future developments)
• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
• Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells appears feasible (personal communication)
  However test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
     especially if it is one of 41+ diseases related to Vitamin D Receptor
  2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
  3) Vitamin D Receptor test (<$30) scores are poor
  4) Back Pain
      probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
        The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene	# of pages Oct 2017	Location
CYP27A1	223	Liver
CYP2R1	626	Tissue
Vitamin D Binding Protein GC	3,450	Blood
CYP27B1	803	Kidney & Tissue
Vitamin D Receptor	6,030	Cell Tissue
CYP24A1	745	excrete excess

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Additional Vitamin D information

   from Increased visibility for VitaminDWiki pages

VitaminDWiki page	Comment
Does Less Sun mean More Disease	5 minute video summary
Some people have problems with vitamin D	Typically low Magnesium
One pill every two weeks gives you all the vitamin D most adults need	50,000 IU every 2 weeks
Vitamin D bulb for use in the home - or perhaps office
Vitamin D from low-cost UVB lamps
Hearing Loss appears to be prevented and treated with vitamin D
Vitamin D reduces hair loss
Headache with vitamin D may mean you need Magnesium
60,000 IU vitamin D weekly with daily Calcium was safe but not enough in the winter – 2012
Vitamins To Speed Up Metabolism And Aid Weight Loss – May 2011
Low cost vitamin D Blood Tests
Gallbladder removal and vitamin D deficiency	If Gallbladder has been removed must take some other form of Vit D Water soluable, etc.
Many reasons why vitamin D deficiency has become epidemic	35 reasons, 20 are new during the past 40 years
Intervention - Vitamin D	270 Vitamin D intervention studies
Diseases which are related due to vitamin D deficiency
Reasons for low response by vitamin D level in the blood
Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015	Example of huge Return On Investements
Vitamin D sprayed inside cheeks 2X more response than taken orally – Oct 2015
Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D)	"It is difficult to get a man to understand something when his salary is dependent upon his not understanding it"

Shorturl = http://is.gd/VitDisgd (Vitamin D Is Good)