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Health problems not vary with vitamin D if everyone has enough (bacterial meningitis in this case) – June 2018

Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis

Clinical Trial Acta Paediatr. 2018 Dec;107(12):2131-2136. doi: 10.1111/apa.14393. Epub 2018 May 31.
Okko Savonius 1, Tuula Pelkonen 1, Irmeli Roine 2, Heli Viljakainen 1 3, Sture Andersson 1, Josefina Fernandez 4, Heikki Peltola 1, Otto Helve 1

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Aim: Vitamin D deficiency impairs the immunological system and has been associated with worse outcomes of infectious diseases, but its role in bacterial meningitis remains unknown. We investigated whether serum 25-hydroxyvitamin D concentrations related to disease outcomes and to cerebrospinal fluid (CSF) cathelicidin concentrations in childhood bacterial meningitis.

Methods: All consecutively enrolled patients in a clinical trial on childhood bacterial meningitis in Latin America in 1996-2003 were considered, and 142 children, with a median age of seven months who had a confirmed bacterial aetiology and frozen serum available for further analyses, were included in this study. Serum 25-hydroxyvitamin D concentrations were determined with a chemiluminescence immunoassay analyser, while CSF cathelicidin was measured by enzyme-linked immunosorbent assay.

Results: The median serum 25-hydroxyvitamin D concentration was 96 (range 19-251) nmol/L. No relationship was found with patient survival, but children with any neurological sequelae had lower serum 25-hydroxyvitamin D levels than children without sequelae. Serum 25-hydroxyvitamin D was unrelated to cathelicidin concentrations in CSF.

Conclusion: Although serum 25-hydroxyvitamin D in children with bacterial meningitis was not associated with survival or CSF cathelicidin concentrations, its relationship with more detailed disease outcomes warrants further study.


Created by admin. Last Modification: Thursday February 25, 2021 01:04:51 GMT-0000 by admin. (Version 5)

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15111 Histogram.jpg admin 25 Feb, 2021 34.44 Kb 167
15110 Vit D levels.jpg admin 25 Feb, 2021 35.93 Kb 161
15109 . bacterial meningitis.pdf admin 25 Feb, 2021 155.38 Kb 172