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HPV 3X higher risk in women who are vitamin D deficient – Jan 2016

The two studies on this page appear to have completely different conclusions

Association Between Serum 25-Hydroxyvitamin D Level and Human Papillomavirus Cervicovaginal Infection in Women in the United States.

J Infect Dis. 2016 Jun 15;213(12):1886-92. doi: 10.1093/infdis/jiw065. Epub 2016 Feb 15.
Shim J1, Pérez A2, Symanski E3, Nyitray AG3.
1 Department of Business Intelligence and Analytics, Texas Children's Health Plan, Houston.
2 Department of Biostatistics, University of Texas School of Public Health, Austin.
3 Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health, Houston.

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BACKGROUND:
A sufficient level of vitamin D enhances protection against several infectious diseases; however, its association with cervicovaginal human papillomavirus (HPV) infection has not been studied.

METHODS:
Data for this cross-sectional study were from National Health and Nutrition Examination Survey 2003-2006. A total of 2353 sexually active women for whom cervicovaginal HPV infection status and serum 25-hydroxyvitamin D (25[OH]D) level were known were studied. Associations between serum 25(OH)D levels (continuous and categorical forms) and cervicovaginal HPV infection (due to high-risk HPV or vaccine-type HPV) were estimated using weighted logistic regression.

RESULTS:
After adjustment for age, race/ethnicity, and marital status, the odds of high-risk HPV infection were increased per each 10 ng/mL decrease in serum 25(OH)D level (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.02-1.27). Similarly, the odds of vaccine-type HPV infection were increased in women with vitamin D levels that were severely deficient (serum 25[OH]D level, <12 ng/mL; aOR, 2.90; 95% CI, 1.32-6.38), deficient (12-19 ng/mL; aOR, 2.19; 95% CI, 1.08-4.45), and insufficient (20-29 ng/mL; aOR, 2.19; 95% CI, 1.22-3.93), compared with those with vitamin D levels that were sufficient (≥30 ng/mL).

CONCLUSIONS:
Cervicovaginal HPV prevalence is associated with less-than-optimal levels of serum vitamin D.


Understanding the role of emerging vitamin D biomarkers on short-term persistence of high-risk HPV infection among mid-adult women - Nov 2020

J Infect Dis,. 2020 Nov 17;jiaa711. doi: 10.1093/infdis/jiaa711
Catherine Troja 1, Andrew N Hoofnagle 2, Adam Szpiro 3, Joshua E Stern 4, John Lin 1, Rachel L Winer 1

Background: Associations between vitamin D biomarkers and persistent high-risk human papillomavirus (hrHPV) detection have not been evaluated.

Methods: 2011-2012 stored sera from 72 women ages 30-50 years with prevalent hrHPV (n=116 type-specific infections) were tested for 5 vitamin D biomarkers: 25(OH)D and 4 emerging biomarkers, 1,25(OH)2D, 24,25(OH)2D, free vitamin D, and vitamin D binding protein (DBP). hrHPV detection patterns (persistent versus transient/sporadic) were determined using cervicovaginal swabs collected monthly for 6 months. Associations between vitamin D and short-term type-specific hrHPV persistence were estimated using logistic regression. Our primary exposure was continuous 25(OH)D, with additional biomarkers evaluated as secondary exposures. Primary models adjusted for age, race, BMI, education, contraceptives, smoking, season, and calcium/phosphate levels. Sensitivity analyses restricted from 19 hrHPV types to 14 used in cervical cancer screening.

Results: In primary analyses, non-significant positive associations with hrHPV persistence were observed for measures of 25(OH)D and 24,25(OH)2D. Associations were stronger and significant restricting to 14 hrHPV types (25(OH)D per 10ng/mL increase:

  • aOR=1.82,95%CI:1.15-2.88 and
  • aOR=4.19,95%CI:1.18-14.88 DBP-adjusted;
  • 25(OH)D≥30 vs <30ng/mL: aOR=8.85,95%CI:2.69-29.06;
  • 24,25(OH)2D: aOR=1.85,95%CI:1.18-2.88).
  • 1,25(OH)2D was unassociated with persistence.

Conclusions: Serum vitamin D measured by multiple biomarkers showed positive associations with short-term hrHPV persistence that were significant only when restricting to 14 clinically-relevant hrHPV types.


Created by admin. Last Modification: Friday November 20, 2020 12:52:03 GMT-0000 by admin. (Version 8)

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