Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study.
J Bone Miner Metab. 2014 Mar 15. [Epub ahead of print]
Morandi G1 grazia.morandi at gmail.com, Maines E, Piona C, Monti E, Sandri M, Gaudino R, Boner A, Antoniazzi F.
Initial growing pain level 7.5
Vitamin D supplementation for 3 months
Vitamin D levels increased to 34 ng (an OK level)
Growing pain level dropped to 2.7
"Growing pains are the most common form of episodic childhood musculoskeletal pain, concerning both males and females"
Vitamin D Council read the PDF behind a $5/month paywall
Children who were deficient (10-20ng) were given 100,000 IU orally monthly for 3 months
Children who were deficient (20-30ng) were given 25,000 IU orally once a month for 3 months
I often had growing pains in my legs as a child living in cloudy Seattle.
Most likely I was vitamin D deficient.
Also, my mom smoked - and smoke is known to decrease vitamin D
A hint that I was vitamin D deficient - I got a sunburn virtually every year.
I also had two other conditions associated with Growing Pains: (comorbid)
restless legs and charlie horse leg cramps
I still had sore tibia and sternum untill a few years ago when I increased by vitamin D levels
Henry Lahore, founder of VitaminDWiki
Download the PDF from VitaminDWiki.
The aim of our study was to analyze the possible relationship between growing pains, vitamin D levels, and bone mineral status. We enrolled 33 children affected by growing pains. Their pain intensity was evaluated through a questionnaire using the Wong-Baker Faces Pain Rating Scale for pain assessment. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), and alkaline phosphatase levels were measured as well. A quantitative ultrasound assessment (QUS) was also done, measuring both the amplitude-dependent speed of sound (AD-SOS) and the bone transmission time (BTT), correlating, respectively, with bone density and with cortical thickness. After 3 and 24 months of vitamin D supplementation, we re-evaluated pain intensity and laboratory results. After 24 months we re-assessed QUS parameters. At the beginning of the study the children reported a mean growing pain intensity of 7.5 ± 1.6 SD. The mean values of 25-OH-D and PTH levels were 15.7 ± 6.9 ng/ml and 57.3 ± 27.3 pg/ml, respectively. The AD-SOS Z score was -0.53 ± 1.19 SD, and the mean value of the BTT Z score was -0.72 ± 0.96 SD. After the first 3 months of vitamin D supplementation we observed an increase in 25-OH-D levels (34.1 ± 17.8, p < 0.001) and a reduction in both PTH levels (47.3 ± 30.6, p = 0.135) and pain intensity (2.7 ± 2.2, p < 0.001). After 24 months we observed a further significant reduction in the pain intensity (3.9 ± 3.4, p < 0.001) and in PTH levels (43.7 ± 28.5, p = 0.004) and an improvement in the QUS parameters, in particular in BTT Z scores (p = 0.014). Our study suggests an interesting relationship between growing pains, vitamin D levels and bone mineral status.
- Uziel Y, Hashkes PJ (2007) Growing pains in children. Pediatr Rheumatol Online J 5:5
- Evans AM, Scutter SD (2004) Prevalence of “growing pains” in young children. J Pediatr 145:255–258 CrossRef
- Kaspiris A, Zafiropoulou C (2009) Growing pains in children: epidemiological analysis in a Mediterranean population. Joint Bone Spine 76:486–490
- Duchamp M (1823) Maladies de la croissance. In: Memoires de Médecine Practique Paris, Jean-Frederic Lobstein Edited by Levrault FG
- Al-Khattat A, Campbell J (2000) Recurrent limb pain in childhood (‘growing pains’). Foot 10:117–123 CrossRef
- Ladhani S, Srinivasan L, Buchanan C et al (2004) Presentation of vitamin D deficiency. Arch Dis Child 89:781–784 CrossRef
- Plotnikoff GA, Quigley JM (2003) Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470 CrossRef
- Straube S, Derry S, Moore RA et al (2010) Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Syst Rev (1):CD007771
- Gloth FM 3rd, Lindsay JM, Zelesnick LB et al (1991) Can vitamin D deficiency produce an unusual pain syndrome? Arch Intern Med 151:1662–1664 CrossRef
- Baeke F, Korf H, Overbergh L et al (2011) The vitamin D analog, TX527, promotes a human CD4 + CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol 186:132–142 CrossRef
- Jones AN, Hansen KE (2009) Recognizing the musculoskeletal manifestations of vitamin D deficiency. J Musculoskelet Med 26:389–396
- Holick MF, Vitamin D (2003) Deficiency: what a pain it is. Mayo Clin Proc 78:1457–1459 CrossRef
- Holick MF (2006) Resurrection of vitamin D deficiency and rickets. J Clin Invest 116:2062–2072 CrossRef
- Holick MF, Vitamin D (2007) Deficiency. N Engl J Med 357:266–281 CrossRef
- Huh SY, Gordon CM (2008) Vitamin D deficiency in children and adolescents: epidemiology, impact and treatment. Rev Endocr Metab Disord 9:161–170 CrossRef
- Gordon CM, Feldman HA, Sinclair L et al (2008) Prevalence of vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolesc Med 162:505–512 CrossRef
- El-Hajj Fuleihan G, Nabulsi M, Choucair M et al (2001) Hypovitaminosis D in healthy schoolchildren. Pediatrics 107:e53
- Pavone V, Lionetti E, Gargano V et al (2011) Growing pains: a study of 30 cases and a review of the literature. J Pediatr Orthop 31:606–609 CrossRef
- Qamar S, Akbani S, Shamim S et al (2011) Vitamin D levels in children with growing pains. J Coll Physicians Surg Pak 21:284–287
- Friedland O, Hashkes PJ, Jaber L et al (2005) Decreased bone strength in children with growing pains as measured by quantitative ultrasound. J Rheumatol 32:1354–1357
- Tomlinson D, von Baeyer CL, Stinson JN et al (2010) A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics 126:1168–1198 CrossRef
- Misra M, Pacaud D, Petryk A et al (2008) Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 122:398–417 CrossRef
- Perrine CG, Sharma AJ, Jefferds ME et al (2010) Adherence to vitamin D recommendations among US infants. Pediatrics 125:627–632 CrossRef
- Holick MF, Binkley NC, Bischoff-Ferrari HA et al (2011) Evaluation, treatment and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930 CrossRef
- Cadossi R, de Terlizzi F, Canè V et al (2000) Assessment of bone architecture with ultrasonometry: experimental and clinical experience. Horm Res 54(Suppl 1):9–18
- Guglielmi G, de Terlizzi F, Scalzo G et al (2010) Cortical thickness and medullary canal dimensions of the bone phalanx are predicted by quantitative ultrasound parameters. J Clin Densitom 13:219–227 CrossRef
- Baroncelli GI (2008) Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance and clinical application. Pediatr Res 63:220–228 CrossRef
- Mauloni M, Rovati LC, Cadossi R et al (2000) Monitoring bone effect of transdermal hormone replacement therapy by ultrasound investigation at the phalanx: a four-year follow-up study. Menopause 7:402–412 CrossRef
- Overview Pain and Vitamin D
- Growing pains associated with low vitamin D - Sept 2015
- Leg cramps in pregnant women not changed by 1,000 IU of vitamin D for 6 weeks (no surprise) – RCT Jan 2017
- Growing pains reduced 57 percent by vitamin D therapy – May 2015 has very similar result
- Search VitaminDWiki for "GROWING PAINS" 69 items as of Feb 2015
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Restless legs and growing pains may be both due to low vitamin D – Sept 2013
which notices that every feature of Restless Legs is common with Growing Pains