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Gingivitis (inflammation of the gums) substantially reduced by Vitamin D – RCT July 2023


A Study to Assess Anti-Inflammatory Effect of Vitamin D on Gingivitis: A Dose Dependent Randomised Controlled Trial

J Pharm Bioallied Sci. 2023 Jul; 15(Suppl 2): S1182–S1184. doi: 10.4103/jpbs.jpbs_169_23
Rahul Srivastava,1 Hadi Raza,2 Pooja Kabra,3 Ashtha Arya,4 Athira Purushothaman,2 and Pallavi A. Thomas5

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Introduction:
Vitamin D deficiency increases gingivitis risk. Studies show that higher vitamin D levels reduce inflammation.

Materials and Methods:
College conducted a double-blind, randomized, controlled trial on 451 people’s vitamin D and gingival health at baseline. For three months, participants were given a placebo (group A), 1000 international units (IU) of vitamin D3 per day (group B-), 500 IU per day (group C), or 2000 IU per day (group A). Gingival scores were recorded for three months to assess the anti-inflammatory effect (the first, second, and third). Vitamin D levels also affected gingivitis.

Results:
Vitamin D dose-dependently reduces gingivitis inflammation. Vitamin D administration negatively correlated with gingival index score. Anti-inflammatory vitamin D levels are 32–37 ng/ml.

Conclusion:
Vitamin D supplementation can reduce gingivitis severity. The optimal blood vitamin D level is 30–35 ng/ml.
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Attached files

ID Name Comment Uploaded Size Downloads
20112 Gingivitis.jpg admin 19 Sep, 2023 91.55 Kb 106
20111 Gingivitis RCT.pdf admin 19 Sep, 2023 498.67 Kb 78