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Getting more than 1,000 IU of Vitamin D cut in half childhood risk of influenza, coughs and fevers – Meta-analysis May 2024


High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis

Nutrition Reviews, Volume 82, Issue 5, May 2024, Pages 579–599, https://doi.org/10.1093/nutrit/nuad082
Janet Adede Carboo, Robin Claire Dolman-Macleod, Linda Malan, Martani Johanni Lombard

Context
Vitamin D plays an important role in immune function, and the deficiency thereof has been associated with several infections, most notably respiratory tract infections. However, data from intervention studies investigating the effect of high-dose vitamin D supplementation on infections have been inconclusive.

Objective
The aim of this study was to evaluate the level of evidence regarding the efficacy of vitamin D supplementation above the standard dose (400 IU) in preventing infections in apparently healthy children < 5 years of age.

Data Sources
PubMed, Scopus, Science Direct, Web of Science, Google Scholar, CINAHL, and MEDLINE electronic databases were searched between August 2022 and November 2022. Seven studies met the inclusion criteria.

Data Extraction
Meta-analyses of outcomes in more than one study were performed using Review Manager software. Heterogeneity was evaluated using the I2 statistic. Randomized controlled trials in which vitamin D was supplemented at > 400 IU compared with placebo, no treatment, or standard dose were included.

Data Analysis
Seven trials that enrolled a total of 5748 children were included. Odds ratios (ORs) with 95% CIs were calculated using random- and fixed-effects models. There was no significant effect of high-dose vitamin D supplementation on the incidence of upper respiratory tract infection (OR, 0.83; 95%CI, 0.62–1.10).
There was a 57% (95%CI, 0.30–0.61), 56% (95%CI, 0.27–0.07), and 59% (95%CI, 0.26–0.65) reduction in the odds of influenza/cold, cough, and fever incidence, respectively, with daily supplementation of vitamin D > 1000 IU. No effect was found on bronchitis, otitis media, diarrhea/gastroenteritis, primary care visits for infections, hospitalizations, or mortality.

Conclusion
High-dose vitamin D supplementation provided no benefit in preventing upper respiratory tract infections (moderate certainty of evidence) but reduced the incidence influenza/cold (moderate certainty of evidence), cough, and fever (low certainty of evidence). These findings are based on a limited number of trials and should be interpreted with caution. Further research is needed


86+ VitaminDWiki pages have INFLUENZA OR FLU OR COLD OR COUGH OR FEVER in the title

This list is automatically updated. Does not include hay, bird, vaccination, month, vaccine, swine, or low level

Items found: 87
Title Modified
Familial Mediterranean Fever is associated with poor genes (and a poor vitamin D receptor) – June 2024 20 Jun, 2024
Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis Jan 2022 17 Jun, 2024
Getting more than 1,000 IU of Vitamin D cut in half childhood risk of influenza, coughs and fevers – Meta-analysis May 2024 31 May, 2024
A common recurrent childhood fever (PFAPA) was reduced by half by 2000 IU of daily vitamin D – Oct 2023 23 Oct, 2023
Dengue Fever decimated by Vitamin D - many studies 20 Oct, 2023
Influenza, pneumonia, or ear infections almost 2X more likely if low vitamin D - Jan 2023 24 Aug, 2023
Overview Influenza and vitamin D 16 Jul, 2023
Tripledemic: Flu, COVID, and RSV (all fought by Vitamin D) - Oct 2022 31 Oct, 2022
Do you have symptoms of COVID, Flu , RSV, Colds, Allergy - Oct 2022 28 Oct, 2022
Influenza infection 5X less likely if got vitamin D – small RCT Feb 2022 23 Oct, 2022
Pigs used to get the flu only in the winter ( had got Vitamin D in the summer) - Nov 2018 23 Oct, 2022
Compare symptoms of Omicron, Flu and Colds 20 Sep, 2022
MS flu-like symptoms resulting from interferon-beta were reduced with vitamin D – June 2013 24 Mar, 2022
Overview Colds and flu and Vitamin D 09 Feb, 2022
Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022 25 Jan, 2022
COVID-19 and Influenza patients needing ventilation had low Vitamin D – Oct 2021 22 Oct, 2021
Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021 17 Oct, 2021
Valley fever may be prevented and treated with Vitamin D 25 Sep, 2021
Respiratory Tract Infections during cold weather – similar rates for low and very low vitamin D – Sept 2021 24 Sep, 2021
US COVID-19 deaths now exceed 1918 flu, soon AIDS (Vitamin D fights all 3) - Sept 19, 2021 22 Sep, 2021
Influenza of 1918 and vitamin D - July 2010 22 Sep, 2021
Clear Association between Influenza and low Vitamin D - March 2020 12 May, 2021
Flu 26 Apr, 2021
COVID-19 precautions made 2020 the year without the flu - what about 2021 17 Mar, 2021
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018 03 Mar, 2021
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017 17 Feb, 2021
Colds substantially reduced by Vitamin D or UV during military training – Jan 2021 24 Jan, 2021
Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 26 Dec, 2020
Protect your immune system from COVID-19, flu, colds, etc with 10,000 IU of vitamin D etc. - Nov 2020 05 Dec, 2020
Familial Mediterranean Fever is associated with poor Vitamin D Binding Protein – Nov 2020 12 Nov, 2020
COVID-19, flu, virus, Selenium, Vitamin D, Glutathione - Interview Sept 2020 29 Sep, 2020
Low vitamin D increases the risk of hepatitis, influenza, Covid-19, AIDS and other viral diseases – Sept 2020 21 Sep, 2020
Childhood colds reduced 25 percent by weekly Vitamin D – RCT Jan 2019 19 Jul, 2020
Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020 07 Apr, 2020
Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 30 Mar, 2020
Influenza Virus aerosols killed by 10 minutes of sunlight (far faster if use UV-C) – Nov 2019 16 Feb, 2020
Virus (adeno-36) increases Obesity which then increases risk of another virus (Influenza) - Oct 2013 07 Nov, 2019
2017 Flu in Australia was bad and 79,000 died in US, 2019 Flu in Australia was worse (get flu shot AND Vitamin D) 04 Oct, 2019
Children with periodic fevers (PFAPA) have half the vitamin D levels of others – June 2019 14 Jun, 2019
How Vitamin D helps fight the cold, flu and other viruses - June 2019 04 Jun, 2019
Acute rheumatic fever associated with lower vitamin D – July 2017 25 Apr, 2019
Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019 03 Feb, 2019
Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin 06 Jan, 2019
Review of common cold (42 billion dollars) prevention and treatment - Zinc works – Feb 2014 05 Jan, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017 13 Jun, 2018
Benefits of Micronutrients, fasting, saunas, intense exercise, cold showers – Patrick April 2018 21 Apr, 2018
Dickensian diseases are returning – rickets, gout, whooping cough, TB, etc. (low vitamin D) 01 Apr, 2018
Elderly Influenza deaths do not increase in winter in countries with high vitamin D levels 09 Feb, 2018
Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017 23 Jan, 2018
Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010 10 Jan, 2018
Take Vitamin D with flu shot: 5X more likely to avoid flu and 10X fewer side effects - Jan 2018 09 Jan, 2018
Prisoners have very low vitamin D and get TB, influenza, and depression 21 Dec, 2017
Child is 2 X more likely to get influenza if have older sibling (perhaps closely-spaced birth) – Sept 2017 28 Sep, 2017
Dengue fever - 8X higher risk for getting worse if low vitamin D – Sept 2017 15 Sep, 2017
Stopped my cold in 1 day (3 of the 9 techniques used fast-acting Vitamin D) July 2017 29 Jul, 2017
Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 14 Nov, 2016
Vitamin C is important for the common cold and much else 14 Sep, 2016
Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015 11 Jun, 2016
Dengue Fever associated with poor vitamin D receptor – July 2002 01 May, 2016
Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015 25 Nov, 2015
4.5X more likely to catch a cold if low sleep - hypothesis - due to low vitamin D 13 Oct, 2015
Colds not decreased if people already vitamin D sufficient – RCT Oct 2012 13 Oct, 2015
Common cold (Acute Rhinosinusitis) 12 percent more likely for every 10 nanogram lower Vitamin D – Oct 2015 13 Oct, 2015
Reduce probability of getting the Flu 02 Sep, 2015
Familial Mediterranean fever – poor response to colchicine if low vitamin D – June 2015 13 Jun, 2015
Major interactions between Vitamin D, Vitamin A, and Influenza – Sept 2013 05 Dec, 2014
Influenzas – both seasonal and pandemic – increase in the winter (low vitamin D) – Dec 2010 07 Nov, 2014
Influenza, solar radiation and vitamin D - 2009 07 Nov, 2014
Ebola - tents probably faster and better than buildings - like in Spanish Flu 11 Oct, 2014
On the epidemiology of influenza – 2008 09 Oct, 2014
Epidemic influenza and vitamin D – 2007 09 Oct, 2014
Antibiotics for Q-Fever result in photosensitivity and huge drop in vitamin D levels – Dec 2013 20 Jun, 2014
Influenza, seniors and vitamin D – Jan 2012 27 Apr, 2014
Reduction in Cold and Flu with Vitamin D 07 Dec, 2013
Influenza Mortality not well modeled by vitamin D – Oct 2011 02 Sep, 2013
3X more colds by overweight who were low on vitamin D - April 2012 05 Oct, 2012
Influenza in Norway not reduced by vitamin D – Oct 2011 03 Sep, 2012
More response to 1100 IU vitamin D in cold season or less BMI – May 2012 15 May, 2012
Flu Hits 14 year low, perhaps Vitamin D 02 Apr, 2012
Should seniors get a vitamin D booster shot for Influenza – Jan 2012 19 Dec, 2011
Can Vitamin D Replace Flu Shots – WSJ Dec 2010 17 Jul, 2011
Elderly taking extra vitamin D should expect fewer falls AND less flu – June 2011 07 Jun, 2011
Inexpensive Trick to Cure a Cold - vitamin D - Mercola Nov 2010 22 Nov, 2010
Pregnant women at increased influenza risk – letter to editor Aug 2010 21 Aug, 2010
Influenza not reduced by 2000 IU of vitamin D in health adults – Aug 2010 17 Aug, 2010
Flu incidence based on prescriptions – US updated map – Late 2019 No value for &#039;modification_date_major&#039;

VitaminDWiki - 81 Infant-Child intervention trials

This list is automatically updated


VitaminDWiki - 26 Infant-Child Meta-analyses

This list is automatically updated


Liquid Vitamin D nanoemulsion seems best for children - no swallowing problems, low cost

Nutrasal $25 bottle contains 2,000,000 IU of Vitamin D
If take 20,000 IU weekly (1/2 dropper), one bottle would last 100 weeks
The dose size varies with the child's weight
100 IU/kg/day is a typical recommendation
   which is 700 IU/kg/week
     20,000 IU weekly would be enough for a 28 kg infant

The Nutrasal nanoemulsion:

  • Is the lowest cost
  • Has a pleasant, somewhat sweet taste,
  • Does not need to be taken with a fatty meal
  • Can be added to water, juice, etc,
  • Can be taken sublingually if there is an upset gut
      or an emergency requires a fast increase in Vitamin D level
      such as: 4X as much just once if Influenza, COVID, pre-surgery,
  • Can be used topically for skin problems (warts, abrasions, psoriasis, wounds, etc)