Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.
Aging Male. 2015 Nov 10:1-6. [Epub ahead of print]
Gutiérrez-Robledo LM 1, Ávila-Funes JA 2,3, Amieva H 3, Meillon C3, Acosta JL 4,5, Navarrete-Reyes AP 2, Torres-Carrillo N 6, Muñoz-Valle JF 6, Torres-Carrillo NM1, 6.
1a Instituto Nacional de Geriatría , México, D.F. , Mexico .
2b Departamento de Geriatría , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , México, D.F. , Mexico .
3c Centre de recherche Inserm , U897, Bordeaux , France ; Univ Victor Segalen Bordeaux 2, Bordeaux , France .
4d Departamento de Microbiología y Patología , Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico .
5e Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR)-Unidad Sinaloa , Sinaloa , Mexico , and.
6f Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico.
Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.
Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured.
Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have
- lower Mini-Mental State Examination score (p = 0.015),
- more disability for instrumental activities of daily living (p < 0.001)
- and for activities of daily living (p < 0.001).
Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one (p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00-8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41-33.30) of vitamin D levels and frailty even after adjusting for potential confounders.
These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.
- Overview Seniors and Vitamin D
- Overview Fractures and Falls and Vitamin D
- Seniors 2.2 X more likely to walk slowly if very low vitamin D – meta-analysis Dec 2017
- Search VitaminDWiki for FRAILITY 142 items as of Nov 2016
- Vertigo treated by Vitamin D - many studies
- Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016
- 80 percent of the characteristics of frailty associated with low vitamin D – May 2013
- Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015
- Fraility Call to Action: Vitamin D is one of the action items – June 2013
- Fraility and low muscle mass both associated with low vitamin D – Aug 2013
- Frailty associated with low levels of vitamin D – 2012, 2016
- Low vitamin D associated with all-cause mortality and frailty – Mar 2011
- Senior skin produces 3X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptors as they age
(The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
- Seniors are indoors more than when when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures
(if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
- Seniors wear more clothing outdoors than when younger
fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
- Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
- Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
- Seniors generally put on weight at they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Seniors not have as much Magnesium needed to use vitamin D
(would not show up on vitamin D test)
- Seniors with poorly functioning kidneys do not process vitamin D as well
(would not show up on vitamin D test) 2009 full text online Also PDF 2009
- Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)
- Category Seniors and Vitamin D