Loading...
 
Translate Register Log In Login with facebookLogin and Register

Fracture mechanics of human bone, and the importance of vitamin D – Sept 2015

The fracture mechanics of human bone: influence of disease and treatment.

Bonekey Rep. 2015 Sep 2;4:743.
Zimmermann EA 1, Busse B 1, Ritchie RO 2.
1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf , Hamburg, Germany.
2Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, CA, USA ; Department of Materials Science & Engineering, University of California , Berkeley, CA, USA.

Aging and bone diseases are associated with increased fracture risk. It is therefore pertinent to seek an understanding of the origins of such disease-related deterioration in bone's mechanical properties. The mechanical integrity of bone derives from its hierarchical structure, which in healthy tissue is able to resist complex physiological loading patterns and tolerate damage. Indeed, the mechanisms through which bone derives its mechanical properties make fracture mechanics an ideal framework to study bone's mechanical resistance, where crack-growth resistance curves give a measure of the intrinsic resistance to the initiation of cracks and the extrinsic resistance to the growth of cracks. Recent research on healthy cortical bone has demonstrated how this hierarchical structure can develop intrinsic toughness at the collagen fibril scale mainly through sliding and sacrificial bonding mechanisms that promote plasticity. Furthermore, the bone-matrix structure develops extrinsic toughness at much larger micrometer length-scales, where the structural features are large enough to resist crack growth through crack-tip shielding mechanisms. Although healthy bone tissue can generally resist physiological loading environments, certain conditions such as aging and disease can significantly increase fracture risk. In simple terms, the reduced mechanical integrity originates from alterations to the hierarchical structure. Here, we review how human cortical bone resists fracture in healthy bone and how changes to the bone structure due to aging, osteoporosis, vitamin D deficiency and Paget's disease can affect the mechanical integrity of bone tissue.

PMID: 26380080

Publisher rents the PDF for $4
Excellent detailed explanation of how healthy bones resist fractures and why the lack of vitamin D changes bone strength
Vitamin D summary from the PDF
Image
Image


See also VitaminDWiki

The TOP articles in Bone Health and Vitamin D are listed here:

Pages listed in BOTH the categories Bone and Magnesium

Pages listed in BOTH the categories Bone and Vitamin K2

Attached files

ID Name Comment Uploaded Size Downloads
5935 Bone 2.jpg admin 18 Sep, 2015 16:03 22.05 Kb 373
5934 Bone 1.jpg admin 18 Sep, 2015 16:03 67.99 Kb 407
See any problem with this page? Report it (FINALLY WORKS)