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Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023


Nonskeletal and skeletal effects of high doses versus low doses of vitamin D3 in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial

Am J Transplant . 2023 Jan 9;S1600-6135(22)29286-7. doi: 10.1016/j.ajt.2022.12.007
Marie Courbebaisse 1, Aurelie Bourmaud 2, Jean-Claude Souberbielle 3, Rebecca Sberro-Soussan 4, Valérie Moal 5, Yannick Le Meur 6, Nassim Kamar 7, Laetitia Albano 8, Antoine Thierry 9, Jacques Dantal 10, Clément Danthu 11, Karine Moreau 12, Emmanuel Morelon 13, Anne-Elisabeth Heng 14, Dominique Bertrand 15, Nadia Arzouk 16, Peggy Perrin 17, Marie-Pascale Morin 18, Philippe Rieu 19, Claire Presne 20, Philippe Grimbert 21, Didier Ducloux 22, Matthias Büchler 23, Moglie Le Quintrec 24, Nacéra Ouali 25, Vincent Pernin 26, Nicolas Bouvier 27, Antoine Durrbach 28, Eric Alamartine 29, Christine Randoux 30, Virginie Besson 31, Marc Hazzan 32, Justine Pages 33, Sandra Colas 34, Marie-Liesse Piketty 3, Gérard Friedlander 35, Dominique Prié 36, Corinne Alberti 2, Eric Thervet 37

Vitamin D sufficiency is associated with a reduced risk of fractures, diabetes mellitus, cardiovascular events, and cancers, which are frequent complications after renal transplantation. The VITALE (VITamin D supplementation in renAL transplant recipients) study is a multicenter double-blind randomized trial, including nondiabetic adult renal transplant recipients with serum 25-hydroxy vitamin D (25(OH) vitamin D) levels of <30 ng/mL, which is randomized 12 to 48 months after transplantation to receive

  • high (100 000 IU) or
  • low doses (12 000 IU)

of cholecalciferol every 2 weeks for 2 months and then monthly for 22 months.
The primary outcome was a composite endpoint, including diabetes mellitus, major cardiovascular events, cancer, and death. Of 536 inclusions (50.8 [13.7] years, 335 men), 269 and 267 inclusions were in the high-dose and low-dose groups, respectively. The serum 25(OH) vitamin D levels increased by 23 versus 6 ng/mL in the high-dose and low-dose groups, respectively (P < .0001). In the intent-to-treat analysis, 15% versus 16% of the patients in the high-dose and low-dose groups, respectively, experienced a first event of the composite endpoint (hazard ratio, 0.94 [0.60-1.48]; P = .78), whereas
1% and 4% of patients in the high-dose and low-dose groups, respectively, experienced an incident symptomatic fracture (odds ratio, 0.24 [0.07-0.86], P = .03).
The incidence of adverse events was similar between the groups. After renal transplantation, high doses of cholecalciferol are safe but do not reduce extraskeletal complications (trial registration: ClinicalTrials.gov; identifier: NCT01431430).


32+ VitaminDWiki pages have TRANSPLANT in title

Items found: 36
Title Modified
Autism risky if low vitamin D during pregnancy and early life (mice, fecal transplant reversed it) – March 2024 27 Mar, 2024
Vitamin D helps organ transplant - many studies 30 Nov, 2023
Liver transplant failure 2.7X more-likely if low vitamin D - Nov 2023 30 Nov, 2023
Vitamin D 100,000 IU loading dose and stem cell transplants – RCT Oct 2023 31 Oct, 2023
Fecal transplants - many studies 26 Apr, 2023
Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023 25 Jan, 2023
Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 27 Aug, 2021
Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021 07 Aug, 2021
Very low Vitamin D levels after Liver transplant in children (need Calcitriol or topical) – May 2021 03 Jun, 2021
Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021 22 May, 2021
1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021 22 Apr, 2021
Organ Transplant patients probably need more UV and or vitamin D April 2010 24 Mar, 2021
If you are getting a lung transplant you must have vitamin D - April 2012 24 Mar, 2021
Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 18 Dec, 2019
Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019 28 Oct, 2019
Stem Cell Transplants consume vitamin D – July 2011 23 Oct, 2019
Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019 23 Oct, 2019
Fecal transplants could prevent 12,000 C.difficile deaths a year, but one person died, so lets wait – July 2019 01 Aug, 2019
4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 17 Jun, 2019
Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 29 Jun, 2018
Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 27 May, 2017
Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011 17 Apr, 2017
Vitamin D may help after organ transplant – if can give enough – Jan 2011 25 Mar, 2017
4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 25 Mar, 2017
Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012 25 Mar, 2017
Vitamin D and biophospates are needed after organ transplant – Aug 2011 25 Mar, 2017
Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 28 Apr, 2016
Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 26 Jul, 2015
Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 18 May, 2015
400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015 26 Mar, 2015
Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011 28 Aug, 2012
Babies Receive Heart Transplants Instead of Vitamin D Treatment 25 Jun, 2012
Kidney transplant worked better if initially have high level of vitamin D – April 2012 28 Apr, 2012
Vitamin D levels low both before and after organ transplant July 2011 27 Apr, 2012
Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009 12 Nov, 2011
Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012 No value for &#039;modification_date_major&#039;