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Following brain surgery Vitamin D injections did not raise blood levels much – RCT June 2019

Effect of Vitamin D Supplementation on Post Craniotomy Pain after Brain Tumor Surgery: a Randomized Clinical Trial

MelikaHMI-KetabforoushMSc1 Mohammadreza Shahmohammadi MD 2 BatoulKhoundabiPh.D3 Zahra Vahdat ShariatpanahiMD, Ph.D1
World Neurosurgery, https://doi.org/10.1016/j.wneu.2019.05.250


300,000 IU injection only raised blood levels from 16 ng ==> 23 ng
Generally no benefit is found in any kind of study when blood levels are less than 30 ng
Oral vitamin D is about 20X less expensive and results in 5X faster response - wonder why they used injection

Injection category contains the following

45 items in Vitamin D Injection category

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  • Injections are currently made by medical professionals into muscle
  • Home injection of Vitamin D appears to be possible in the future
  • Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
  • While Vitamin D2 is historically the common form, Vitamin D3 is far better
  • Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
  • Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
  • 100,000 IU single dose of vitamin D - 2010 has the following
  • Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following

Objective: To determine the effect of vitamin D supplementation on post-operative pain and analgesic requirement in brain tumor surgery.

Methods: A total of 60 patients with vitamin D serum level of ≤ 20 ng/dL were randomly assigned to two groups equally. The study group (n=30) received intramuscular injection of 300,000 IU vitamin D before surgery.

Preoperative serum level of vitamin D was 15.9±3.8 ng/dL and 14.5±3.6 ng/dL in the study and control groups, respectively (P= 0.13). Serum level of vitamin D on day 5 of surgery was 22.5±4.3 and 13.7±3.8 in the study and control groups, respectively (P<0.001). A percentage of 50% had pain scores above 4 on the first postoperative day, which decreased with time. The median (IQR) of the visual analogue scale (VAS) score during the three post-operative days was 3(5), 3(5), 1(3) and 5(7), 2(5), 1(3) in the study and control groups, respectively, with no significant difference. There was no difference in analgesic consumption between the two groups. Analysis through the Generalized Estimating Equation model indicated that patients who had received vitamin D for a longer time before the operative time had an insignificantly less pain score.

Based on the study results, half of our patients reported moderate to severe pain scores on the first day after surgery. The pain in the study group was insignificantly less than that in the control group, but it seems that chronic high level of vitamin D may lead to promising results.

Created by admin. Last Modification: Tuesday June 11, 2019 12:52:40 GMT-0000 by admin. (Version 4)
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