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Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018

Table of contents


Nov 2016

Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency
Int J Rheum Dis. 2016 Nov 11. doi: 10.1111/1756-185X.12960. [Epub ahead of print]
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Yilmaz R1, Salli A2, Cingoz HT3, Kucuksen S2, Ugurlu H2.
1Department of Physical Medicine and Rehabilitation, Yoncali Physical Medicine and Rehabilitation Hospital, Kutahya, Turkey.
2Department of Physical Medicine and Rehabilitation, Meram Medical School, Necmettin Erbakan University, Konya, Turkey.
3Department of Physical Medicine and Rehabilitation, Seydisehir State Hospital, Konya, Turkey.

AIM:
The objective of this study is the evaluation of the effect of vitamin D replacement treatment on musculoskeletal symptoms and quality of life in patients with chronic widespread musculoskeletal pain (CWP) including fibromyalgia (FM) and vitamin D deficiency.

METHOD:
Patients with nonspecific CWP and vitamin D deficiency (25-OH D3 < 25 ng/mL) were included into the study. Replacement treatments of 50 000 IU/week oral vitamin D3 for 3 months were given to the patients. Patients were assessed pre- and post-treatment in terms of serum levels of Ca, P, alkaline phosphatase, 25-OH D3, severity of pain (visual analogue scale [VAS]-pain), severity of asthenia (VAS-asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]-36), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction.

RESULTS:
Fifty-eight patients with a mean age of 36.9 ± 9.2 years were included into the study. 25-OH D3 levels of patients elevated from 10.6 ± 5.1 ng/mL to 46.5 ± 24.0 ng/mL after replacement treatment (P < 0.001).
Marked decrease in

  • VAS-pain,
  • VAS-asthenia,
  • severity of waking unrefreshed, TPC, and BDI

and an evident increase in

  • subgroups of SF-36

were established in patients after treatment (P < 0.001).
The number of FM+ patients was 30 (52%) before treatment and regressed to 20 (34%) after treatment (P = 0.013); 85% of patients stated satisfaction with the treatment.

CONCLUSIONS:
Vitamin D replacement treatment in patients with nonspecific CWP has provided improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be investigated for vitamin D deficiency.

PMID: 27860257 DOI: 10.1111/1756-185X.12960


June 2017

Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia
Most of the Quality of life parameters were statistically improved by weekly 50,000 IU of vitamin D
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June 2018

__Vitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary Results
Isr Med Assoc J. 2018 Jun;20(6):379-381.
de Carvalho JF, da Rocha Araújo FAG, da Mota LMA, Aires RB, de Araujo RP.
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BACKGROUND:
Vitamin D deficiency and insufficiency have been reported in fibromyalgia. However, to the best of our knowledge, only one study has evaluated the role of 25-hydroxyvitamin D [25(OH)D] supplementation on fibromyalgia symptoms.

OBJECTIVES: To analyze the effects of 3 months of 25(OH)D supplementation on symptoms of fibromyalgia.

METHODS: This study included 11 female patient. Demographic and clinical data, tender points, visual analog scale results, and pre- and post-serum levels of 25(OH)D supplementation were analyzed. The levels of 25(OH)D were measured by a radioimmunologic test.

RESULTS:
Patients with fibromyalgia diagnosis and 25(OH)D values ≤ 30 ng/ml were recruited to receive 50,000 IU of oral vitamin D once every week for 3 months. The disease was diagnosed based on the American College of Rheumatology criteria. The median age of all patients was 48.5 (28-67) years and 63.4% were Caucasian. Disease duration varied from 1-10 years. The 25(OH)D levels increased significantly after 3 months, 18.4 (15.5-25.8) ng/ml vs. 33.8 (28-58) ng/ml, P = 0.01. Interestingly, an improvement of visual analog scale scores was observed at 3 months, 90 (0-100) vs. 30 (0-80), P = 0.002. Eight patients (72.2%) responded that they experienced a very significant improvement in symptoms. In addition, a trend for reduction of the number of tender points was observed after 3 months, 17 (11-18) vs. 10 (0-18), P = 0.07.

CONCLUSIONS: The 25(OH)D levels and disease symptoms in patients with fibromyalgia and vitamin D deficiency/insufficiency seem to improve with vitamin D supplementation.

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Created by admin. Last Modification: Thursday May 23, 2019 11:56:18 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
12003 Fibro June 2018.pdf PDF 2018 admin 23 May, 2019 11:52 89.62 Kb 31
8420 CWP T2.jpg admin 13 Sep, 2017 10:51 94.35 Kb 829
8419 Widespread pain 2016.pdf PDF 2016 admin 13 Sep, 2017 10:51 151.16 Kb 204
8139 Fibro QoL.JPG admin 27 Jun, 2017 10:05 60.18 Kb 977
8138 QoL Firbomyalgia.pdf admin 27 Jun, 2017 10:05 137.89 Kb 155
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