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Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017

Two Fibromyalgia Vitamin D intravention studies in Turkey:
successful weekly treatment with 50,000 IU

Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency - Nov 2016

Int J Rheum Dis. 2016 Nov 11. doi: 10.1111/1756-185X.12960. [Epub ahead of print]

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Yilmaz R1, Salli A2, Cingoz HT3, Kucuksen S2, Ugurlu H2.
1Department of Physical Medicine and Rehabilitation, Yoncali Physical Medicine and Rehabilitation Hospital, Kutahya, Turkey.
2Department of Physical Medicine and Rehabilitation, Meram Medical School, Necmettin Erbakan University, Konya, Turkey.
3Department of Physical Medicine and Rehabilitation, Seydisehir State Hospital, Konya, Turkey.

The objective of this study is the evaluation of the effect of vitamin D replacement treatment on musculoskeletal symptoms and quality of life in patients with chronic widespread musculoskeletal pain (CWP) including fibromyalgia (FM) and vitamin D deficiency.

Patients with nonspecific CWP and vitamin D deficiency (25-OH D3 < 25 ng/mL) were included into the study. Replacement treatments of 50 000 IU/week oral vitamin D3 for 3 months were given to the patients. Patients were assessed pre- and post-treatment in terms of serum levels of Ca, P, alkaline phosphatase, 25-OH D3, severity of pain (visual analogue scale [VAS]-pain), severity of asthenia (VAS-asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]-36), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction.

Fifty-eight patients with a mean age of 36.9 ± 9.2 years were included into the study. 25-OH D3 levels of patients elevated from 10.6 ± 5.1 ng/mL to 46.5 ± 24.0 ng/mL after replacement treatment (P < 0.001).
Marked decrease in

  • VAS-pain,
  • VAS-asthenia,
  • severity of waking unrefreshed, TPC, and BDI

and an evident increase in

  • subgroups of SF-36

were established in patients after treatment (P < 0.001).
The number of FM+ patients was 30 (52%) before treatment and regressed to 20 (34%) after treatment (P = 0.013); 85% of patients stated satisfaction with the treatment.

Vitamin D replacement treatment in patients with nonspecific CWP has provided improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be investigated for vitamin D deficiency.

PMID: 27860257 DOI: 10.1111/1756-185X.12960

Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia - June 2017

Most of the Quality of life parameters were statistically improved by weekly 50,000 IU of vitamin D
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This page was renamed June 2017 when the 2017 study was added

Attached files

ID Name Comment Uploaded Size Downloads
8420 CWP T2.jpg admin 13 Sep, 2017 10:51 94.35 Kb 680
8419 Widespread pain 2016.pdf PDF 2016 admin 13 Sep, 2017 10:51 151.16 Kb 159
8139 Fibro QoL.JPG admin 27 Jun, 2017 10:05 60.18 Kb 828
8138 QoL Firbomyalgia.pdf admin 27 Jun, 2017 10:05 137.89 Kb 123
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