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Female mortality predicted better by vitamin D than by C-Reactive Protein – Dec 2013

Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome:
A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein

Cardiology Research and Practice, Volume 2013 (2013), Article ID 398034, 8 pages, http://dx.doi.org/10.1155/2013/398034
Patrycja A. Naesgaard,1,2 Ricardo A. León de la Fuente,1,3 Stein Tore Nilsen,4 Leik Woie,1,3 Torbjoern Aarsland,4 Harry Staines,5 and Dennis W. T. Nilsen1,3
1 Department of Cardiology, Stavanger University Hospital, 4068 Stavanger, Norway
2 Institute of Medicine, University of Bergen, 5021 Bergen, Norway
3 Cardiology Research Institute, Catholic University of Salta, A4400ANG Salta, Argentina
4 Department of Research, Stavanger University Hospital, 4068 Stavanger, Norway
5 Sigma Statistical Services, Balmullo KY16 0BJ, UK

Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP). Blood samples were harvested on admission in 982 patients. Forty percent were women (65.9 ± 12.6 years). Mortality was evaluated in quartiles of 25(OH)D, BNP, and hsCRP, respectively, during a 5-year follow-up, applying univariate and multivariate analyses. One hundred and seventy-three patients died; 78 were women. In 92 patients (37 women), death was defined as cardiac. In women, the univariate hazard ratio (HR) for total death of 25(OH)D in Quartile (Q) 2 versus Q1, Q3 versus Q1, and Q4 versus Q1 was 0.55 (95% CI 0.33–0.93), 0.29 (95% CI 0.15–0.55), and 0.13 (95% CI 0.06–0.32), respectively. In females, it was an independent predictor of total and cardiac death, whereas BNP and hsCRP were less gender-specific. No gender differences in 25(OH)D were noted in a reference material. Accordingly, vitamin D independently predicts mortality in females with suspected ACS.
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Q1= 27 nmol (11 ng),   Q2= 39 nmol (16 ng),   Q3= 51 nmol (20 ng),   Q4= 68 nmol (27 ng)

Mortality vs vitamin D

Image

PDF is attached at the bottom of this page

Comment by VitaminDWiki: There is also a strong possibility that supplementing with Vitamin D will treat the problem!

See also VitaminDWiki

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1422

Short url = http://is.gd/vitdcrp



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3412 Predict SS.jpg admin 20 Dec, 2013 11:30 46.25 Kb 894
3411 Predict.pdf PDF - 2013 admin 20 Dec, 2013 11:29 2.22 Mb 639
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