Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats.
United European Gastroenterol J. 2018 Aug;6(7):1056-1064. doi: 10.1177/2050640618774140. Epub 2018 May 17.
Mazzone G1, Morisco C 2, Lembo V 1, D'Argenio G 1, D'Armiento M 2, Rossi A 1, Giudice CD 2, Trimarco B2, Caporaso N 1 nicola.caporaso at unina.it , Morisco F 1.
1 Gastroenterology, Department of Clinical Medicine and Surgery, University 'Federico II', Naples, Italy.
2 Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.
|Standard Diet||Western Diet||Western Diet |
+ Vitamin D
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Overview Liver and vitamin D contains the following summary
- Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
- Fact: Liver diseases often result in lower levels of vitamin D
- Fact: Various pain relievers damage the liver function
- Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
- Options with a poorly functioning liver appear to be:
- Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
- Increase the response you get from vitamin D
- Increase sunshine / UVB,
- Get the response you get from the sun/UVB
- Consider supplementing with Iron - a patented Iron supplement appears to work very well
- Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
- Get Calcidiol which does not need the liver
- Use Topical Vitamin D - activation by the skin etc does not require the liver
Diabetes category starts with the following
PDF is available free at Sci-Hub 10.1177/2050640618774140
The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.
To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.
Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.
Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.
In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects.
- Tappy L and Le KA. Metabolic effect of fructose and the worldwide increase in obesity. Physiol Rev 2010; 90: 23-46.
- Masuoka HC and Chalasani N. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci 2013; 1281: 106-122.
- Ahmed MH, Husain NE and Almobarak AO. Nonalcoholic Fatty liver disease and risk of diabetes and cardiovascular disease: what is important for primary care physicians? J Fam Med Prim Care 2015; 4: 45-52.
- Hamaguchi M, Kojima T, Takeda N, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007; 13: 1579-1584.
- Pacifico L, Di Martino A, De Merulis M, et al. Left ventricular dysfunction in obese children and adolescents with nonalcoholic fatty liver disease. Hepatology 2014; 59: 461-470.
- Lonardo A, Sookoian S, Pirola CJ, et al. Non-alcoholic fatty liver disease and risk of cardiovascular disease. Metabolism 2016; 65(8): 1136-1150.
- DeFronzo RA and Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabet Care 1991; 14(3): 173-194.
- Reaven GM, Lithell H and Landsberg L. Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996; 334(6): 374-381.
- Anyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-1192.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281.
- Lee JH, O’Keefe JH, Bell D, et al. Vitamin D deficiency: an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008; 52(24): 1949-1956.
- Kwok RM, Torres DM and Harrison SA. Vitamin D and nonalcoholic fatty liver disease (NAFLD): is it more than just an association? Hepatology 2013; 58(3): 1166-1174.
- Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 29: 117(4): 503-511.
- Al Mheid I and Quyyumi AA. Vitamin D and cardiovascular disease: controversy unresolved. J Am Coll Cardiol 2017; 70(1): 89-100.
- Scragg R, Sowers M and Bell C. Serum 25-hydroxyvita- min D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: 2813-2818.
- Trovato F, Castrogiovanni P, Szychlinska MA, et al. Impact of Western and Mediterranean diets and vitamin D on muscle fibers of sedentary rats. Nutrients 2018; 10(2): 231.
- Kalliokoski O, Jacobsen KR, Darusman HS, et al. Mice do not habituate to metabolism cage housing: a three week study of male BALB/c mice. Plos One 2013; 8(3): e58460.
- Lembo G, Iaccarino G, Vecchione C, et al. Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. Hypertension 1995; 26(2): 290-293.
- Mulder P, Morrison MC, Wielinga PY, et al. Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepa- titis in obesity. Int J Obes 2016; 40(4): 675-684.
- Moore CE and Liu Y. Low serum 25-hydroxyvitamin D concentrations are associated with total adiposity of children in the United States: National Health and Examination Survey 2005 to 2006. Nutr Res 2016; 36(1): 72-79.
- Chou CL, Pang CY, Lee TJ, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One 2015; 10(3): e0119843.
- Cordeiro A, Santos A, Bernardes M, et al. Vitamin D metabolism in human adipose tissue: could it explain low vitamin D status in obesity? Horm Mol Biol Clin Investig, Epub ahead of print 18 July 2017. DOI:10.1515/hmbci-2017-0003.
- Faridi KF, Zhao D, Martin SS, et al. Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study. Nutrition 2017; 38: 85-93.
- Tao S, Yuan Q, Mao L, et al. Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes. Oncotarget 2017; 8(40): 67605-67613.
- Simental-Mendia LE, Rodriguez-Moran M and Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord 2008; 6: 299-304.
- Li X, Huang W, Gu J, et al. SREBP-1c overactivates ROS-mediated hepatic NF-kB inflammatory pathway in dairy cows with fatty liver. Cell Signal 2015; 27(10): 2099-2109.
- Yin Y, Yu Z, Xia M, et al. Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism. Eur J Clin Invest 2012; 4211: 1189-1196.
- Bao S, Cao Y, Fan C, et al. Epigallocatechin gallate improves insulin signaling by decreasing toll-like receptor 4 (TLR4) activity in adipose tissues of high-fat diet rats. Mol Nutr Food Res 2014; 58(4): 677-686.
- Cosma A, Cecchet D, Gaiani S, et al. Clinical and biochemical determinants of the extent of liver steatosis in type 2 diabetes mellitus. Eur J Gastroenterol Hepatol 2015; 27(12): 1386-1391.
- Wang H, Zhang Q, Chai Y, et al. 1,25(OH)2D3 down- regulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats. J Endocrinol Invest 2015; 38(10): 1083-1091.
- Panchal SK, Poudyal H, Iyer A, et al. High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol 2011; 57(5): 611-612.
- Ramires FJ, Sun Y and Weber KT. Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade. J Mol Cell Cardiol 1998; 30(3): 475-483.
- Kobayashi R, Nagano M, Nakamura F, et al. Role of angiotensin II in high fructose-induced left ventricular hypertrophy in rats. Hypertension 1993; 21:1051-1055.
- Li YC, Kong J, Wei M, et al. 1,25- Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin- angiotensin system. J Clin Invest 2002; 110: 229-238.
- Hou C, Lu F, Cao K, et al. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin- angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int 2008; 74: 170-179.
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