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Falls and frailty associated with low levels of both vitamins B12 and D3 – June 2023

Association of vitamins B12 and D3 with Balance and Falls in a sample of Greek older people

J Musculoskelet Neuronal Interact . 2023 Jun 1;23(2):205-214.
Konstantinos Stolakis 1, Panagiotis Megas 2, Elias Panagiotopoulos 3, Manolis Mentis 4, Eleftheria Antoniadou 5, Xristina Kalivioti 5, Minos Tyllianakis 2, Zinon Kokkalis 2


Objectives: Balance disorders and falls are common in the elderly and have a multifactorial etiology. The purpose of the present cross-sectional study is to evaluate a possible association between vitamins D3 and B12 and impaired balance and falls.

Methods: Ninety patients, females and males, were evaluated, from December 2019 to December 2020 during their first ambulatory visit at the Prevention of Falls Clinic of the General University Hospital of Patras. Vitamins B12 and D3 levels were measured. The number of falls during the last 12 months was recorded and patients were assessed using Mini-Balance Evaluation Systems Test (Mini-BESTest), Fried Phenotype, Walking Speed, Hand Grip Strength, Short Physical Performance Battery.

Results: A multiple linear regression analysis showed that Mini-BESTest are statistically significantly predicted, F(10,79)=18.734, p<0.001, adj. R2=0.70 from Vit-B12 and FRIED Phenotype (pre-frail vs non-frail). Similarly, in the multiple binary logistic regression analysis, falls were statistically significantly predicted from FRIED Phenotype (pre-frail vs non-frail) ?2(5)=63.918, p<0.001, Nagelkerke R Squared=0.68.

Conclusions: Higher levels of vitamins B12 but not of D3 are associated with better balance but not with less falls in a sample of community-dwelling older people.
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VitaminDWiki – Vitamin B12 contains

Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds

  • B12 deficiency increases with age
  • B12 appears to have no toxic upper limit
  • Some people get frequent B12 injections or I.V, to restore levels
    • Injection may not be needed
  • Only a small portion of B12 taken orally gets into the bloodstream
    • Sublingual B12 may not have that problem
  • B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
  • B12 deficiency symptoms include poor gut - which can reudce reduced uptake of Vitamin D
    • unless use gut friently forms of Vitamin D, including topical
  • B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
    • As with Vitamin D, a massive (loading) dose can restore levels quickly
    • Nano forms of B12 are more bio-available - as with many other supplements
56 items in Vitamin B12 category on VitaminDWiki

VitaminDWiki – Falls and Fractures category contains



VitaminDWiki – Fraility and Vitamin D - many studies 15+

Attached files

ID Name Comment Uploaded Size Downloads
19624 Falls frail table.jpg admin 01 Jun, 2023 15:21 62.30 Kb 49
19623 jmni_23_205.pdf PDF 2023 admin 01 Jun, 2023 13:30 326.62 Kb 20