Endometrial cancer and Vitamin D – many studies

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4+ VitaminDWiki pages with ENDOMETRIAL in the title

This list is automatically updated

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14,400 studies of endometrial cancer and vitamin D - Jan 2024

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• Prospective analysis of vitamin D and endometrial cancer risk - March 2013 FREE PDF no association, everyone had low vitamin D levels
• A population-based cohort study on sun habits and endometrial cancer - June 2009
  • "Exposure to artificial sun by the use of sun beds >3 times per year was associated with a 40% reduction in the risk of endometrial cancer, probably by improving the vitamin D levels during winter."

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See web

• The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer - May 2023 https://doi.org/10.3390/ijms24108665 FREE PDF
• Vitamin D and Its Receptors in Cervical Cancer - Jan 2024 https://doi.org/10.7150/jca.87499 FREE PDF
• Endometrial cancer Vitamin D Council
  Endometrial cancer is one of the top 19 cancers sensitive to vitamin D.
  Vitamin D may reduce the risk of endometrial cancer by 15% to 25%
• Endometrial Cancer Prevention PubMed Health (does not appear to mention Vitamin D)
• Shedding Light on Serum Vitamin D Concentrations and the Risk of Rarer Cancers. Oct 2012 ‘’little support’’
  What If HPV Does Not Cause Cervical Cancer?GreenMedInfo - Jan 2015
• Cervical Cancer Taking Deadlier Toll in U.S. Than Had Been Thought NYT Jan 2017
  "In the new analysis, the mortality rate for
  black women was 10.1 per 100,000. For
  white women, it is 4.7 per 100,000 - approx 2X lower rate for white women

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Study: Vitamin D levels not high enough to find an association with EC - 2012

Prospective analysis of vitamin D and endometrial cancer risk
J. J. Liu1,2,*, K. A. Bertrand1,2, S. Karageorgi3, E. Giovannucci1,2,4, S. E. Hankinson1,2, B. Rosner2,5, L. Maxwell6, G. Rodriguez7 and I. De Vivo1,2

Background This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D].

Methods The prospective cohort analysis of predicted 25(OH)D and total dietary vitamin D intake used the Cox proportional hazards model, and involved 644 incident endometrial cancer events from 1986 to 2006 in the Nurses' Health Study. Genotyping and unconditional logistic regression were carried out on 572 endometrial cancer cases and their matched controls on 12 single nucleotide polymorphisms (SNPs) in vitamin D-related genes.

Results There was no significant association between predicted 25(OH)D and endometrial cancer incidence, with the hazard ratio for the highest (versus the lowest) quintile of predicted 25(OH)D as 1.00 (95% CI 0.73–1.36) (p-trend = 0.33).
There was also no significant association involving total dietary vitamin D.
No significant associations between any of the vitamin D-related SNPs and endometrial cancer were observed.

Conclusion Both predicted 25(OH)D and total dietary vitamin D intake were not associated with endometrial cancer incidence.
These results suggest that vitamin D may not protect against the development of endometrial cancer.
However, the low and narrow vitamin D exposure range in the cohort may limit generalizability of the results.

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Agreed: Most cancers are NOT hindered when vitamin D levels <30 nanograms

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