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Endocrine Society Guideline should be raised to 2 ng per 100 IU of vitamin D – March 2013

Vitamin D dose response is underestimated by Endocrine Society's Clinical Practice Guideline

Endocr Connect 2013 EC-13-0008
Malachi J McKenna mjmckenn at iol.ie and Barbara F Murray
M McKenna, St. Michael's Hospital, Dun Laoghaire, Ireland
B Murray, St. Michael's Hospital, Dun Laoghaire, Ireland

Objective: The recommended daily intakes of vitamin D according to the recent Clinical Practice Guideline (CPG) of the Endocrine Society are 3-to-5-fold higher than the Institute of Medicine (IOM) report. We speculated that these differences could be explained by different mathematical approaches to the vitamin D dose response.

Methods: Studies were selected if the daily dose was <=2000 International Units (IU)/d, the duration exceeded 3 months, and 25-hydroxyvitamin D (25OHD) concentrations were measured at baseline and post-therapy. The rate constant was estimated according to the CPG approach.
The achieved 25OHD result was estimated according to:

  • (1) the regression equation approach of the IOM;
  • (2) the regression approach of the Vitamin D Supplementation in Older Subjects (VIDOS) study; and
  • (3) the CPG approach using a rate constant of 2.5 (CPG2.5)
  • and a rate constant of 5.0 (CPG5.0).

The difference between the expected and observed 25OHD result was expressed as a percentage of observed, and analysed for significance against a value of 0% for the four groups.

Results: Forty-one studies were analysed. The mean (CI) rate constant was 5.3(4.4-6.2) nmol/L /100 IU/d, on average 2-fold higher than the CPG rate constant. The mean (CI) for the difference between the expected and observed expressed as a percentage of observed were:

  • (1) IOM, -7(-16,+2)% (t=1.64, p=0.110);
  • (2) VIDOS, +2(-8,+12)% (t=0.40, p=0.69);
  • (3) CPG2.5, -21(-27,-15)% (t=7.2, p<0.0001); and
  • (4) CPG5.0 +3(-4,+10)% (t=0.91, p=0.366).


Conclusion: The CPG "rule of thumb" should be doubled to 5.0 nmol/L (2.0 ng/ml)/100 IU/d, adopting a more risk-averse position.

Received 9 February 2013; Received in final form 10 March 2013; Accepted 12 March 2013; Accepted Preprint first posted online on 12 March 2013
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PDF is attached at the bottom of this page

Note: This is for vitamin D dose levels of < 2000 IU

See also VitaminDWiki

see wiki page: http://www.vitamindwiki.com/tiki-index.php?page_id=1425

Attached files

ID Name Comment Uploaded Size Downloads
2205 CPG.jpg admin 13 Mar, 2013 13:52 26.23 Kb 775
2204 EC-13-0008.full.pdf PDF admin 13 Mar, 2013 13:52 1.01 Mb 620
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