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Elderly diabetic problems are associated with low vitamin D and often treated as well – 34 study review Feb 2021

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Cureus. 2021 Jan 5;13(1):e12506. doi: 10.7759/cureus.12506.
Ioannis Papaioannou 1, Georgia Pantazidou 2, Zinon Kokkalis 3, Neoklis Georgopoulos 4, Eleni Jelastopulu 5

VitaminDWiki

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 477 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 51;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

Trials will have improved success if they do one or more or the following
1) Use gut-friendly vitamin D    2) Add Magnesium   3) Add Omega-3

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

Items in both categories Diabetes and Meta-analysis are listed here:

 Download the PDF from VitaminDWiki
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Diabetes mellitus type 2 (T2DM) is an emerging public health issue with high prevalence among older adults (>60 years old). Taking into consideration the great increase in the elderly population (approximately 7.5 billion worldwide), we can easily understand the impact of this chronic disease and its complications. On the other hand, vitamin D deficiency (VDD) is also a serious public health problem with significant impacts and multiple health effects. The correlation between DM and VDD has been suggested and established from many observational studies, reviews, and meta-analyses. The literature in PubMed and Google Scholar was searched for relevant articles published up to October 2020.
The keywords used were the following: vitamin D deficiency, elderly, and diabetes mellitus type 2.

Among the 556 articles retrieved, 90 full texts were eligible and only 34 studies (

  • 12 retrospective studies,
  • two prospective cohorts,
  • three meta-analyses,
  • seven cross-sectional studies,
  • nine randomized control trials (RCTs), and
  • one observational study)

met the inclusion criteria for the review. The author's name, year of publication, country, type of study, and the number of patients were reported. According to this review there is adequate evidence to support the correlation between VDD and T2DM in the elderly. The results from the RCTs are more conflicting and more studies are needed to confirm the impact of vitamin D deficiency (VD) supplementation on metabolic and lipid profile, oxidative stress, and the complications of T2DM in older patients. VDD is clearly related with severe retinopathy, diabetic peripheral neuropathy, and poor cognition performance, while there is consensus about the beneficial effect of VD on peripheral artery disease, foot ulceration prevention, and wound healing. On the other hand, there is controversy about the effect of VD supplementation on cardiovascular adverse events, endothelial function, and estimated glomerular filtration rate (eGFR). Finally, the association of VDD with fragility fractures and depression in the elderly with T2DM is currently insufficiently studied and remains controversial.


Created by admin. Last Modification: Thursday February 11, 2021 15:35:01 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
15016 TIID review.jpg admin 11 Feb, 2021 15:12 584.30 Kb 49
15015 T2D review.pdf PDF 2021 admin 11 Feb, 2021 15:11 540.21 Kb 38
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