Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review
Cureus. 2021 Jan 5;13(1):e12506. doi: 10.7759/cureus.12506.
Ioannis Papaioannou 1, Georgia Pantazidou 2, Zinon Kokkalis 3, Neoklis Georgopoulos 4, Eleni Jelastopulu 5
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
529 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
'This list is automatically updated''- Dark Skin
24 ; Intervention 56 ; Meta-analysis 38 ; Obesity 34 ; Pregnancy 43 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 23 ; Genetics 12 ; Magnesium 27 Click here to see details Some Diabetes studies
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Trials will have improved success if they do one or more or the following
1) Use gut-friendly vitamin D 2) Add Magnesium 3) Add Omega-3Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Items in both categories Diabetes and Meta-analysis are listed here:
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021
- Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis May 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Diabetic Foot Ulcer 3.2 X or 3.6 X more likely if low vitamin D – several meta-analyses
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis Jan 2018
- Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken) – Sept 2015
- Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis Dec 2014
- Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Diabetes down 13 percent if more than 500 IU of vitamin D – meta-analysis July 2011
Download the PDF from VitaminDWiki
Diabetes mellitus type 2 (T2DM) is an emerging public health issue with high prevalence among older adults (>60 years old). Taking into consideration the great increase in the elderly population (approximately 7.5 billion worldwide), we can easily understand the impact of this chronic disease and its complications. On the other hand, vitamin D deficiency (VDD) is also a serious public health problem with significant impacts and multiple health effects. The correlation between DM and VDD has been suggested and established from many observational studies, reviews, and meta-analyses. The literature in PubMed and Google Scholar was searched for relevant articles published up to October 2020.
The keywords used were the following: vitamin D deficiency, elderly, and diabetes mellitus type 2.Among the 556 articles retrieved, 90 full texts were eligible and only 34 studies (
- 12 retrospective studies,
- two prospective cohorts,
- three meta-analyses,
- seven cross-sectional studies,
- nine randomized control trials (RCTs), and
- one observational study)
met the inclusion criteria for the review. The author's name, year of publication, country, type of study, and the number of patients were reported. According to this review there is adequate evidence to support the correlation between VDD and T2DM in the elderly. The results from the RCTs are more conflicting and more studies are needed to confirm the impact of vitamin D deficiency (VD) supplementation on metabolic and lipid profile, oxidative stress, and the complications of T2DM in older patients. VDD is clearly related with severe retinopathy, diabetic peripheral neuropathy, and poor cognition performance, while there is consensus about the beneficial effect of VD on peripheral artery disease, foot ulceration prevention, and wound healing. On the other hand, there is controversy about the effect of VD supplementation on cardiovascular adverse events, endothelial function, and estimated glomerular filtration rate (eGFR). Finally, the association of VDD with fragility fractures and depression in the elderly with T2DM is currently insufficiently studied and remains controversial.
Elderly diabetic problems are associated with low vitamin D and often treated as well – 34 study review Feb 2021Printer Friendly Follow this page for updates1502 visitors, last modified 11 Feb, 2021, This page is in the following categories (# of items in each category)Attached files
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