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Do You Believe the Myth That You Can't Prevent Alzheimer's – Mercola, Aug 2017

Update: Interview of Dr. Bredesen by Dr. R Patrick Oct 2018

extensive data, hyperlinks, highlights

ReCODE: The Reversal of Cognitive Decline

Story at-a-glance

  • Dr. Dale Bredesen’s ReCODE protocol evaluates 150 factors known to contribute to Alzheimer’s disease. This identifies your disease subtype or combination of subtypes, and an effective treatment protocol can be devised
  • Type 1 Alzheimer’s is primarily caused by inflammatory factors; type 2 involves atrophic responses; type 1.5 is a mix of inflammation and atrophy, and type 3 is primarily caused by toxic exposures
  • Only 5 percent of Alzheimer’s cases are “familial” Alzheimer’s disease, a genetic condition that causes early onset Alzheimer’s; the rest are caused by lifestyle factors over which we have a great deal of control; hence, we have the ability to improve or even reverse most cases of the disease

Includes interview and transcript of Dr. Bredesen, author
The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline Amazon, Aug 2017 $14 Kindle

4 Alzheimer’s Subtypes

While these classifications have not become widely accepted yet, Bredesen has published two papers on Alzheimer’s subtypes, based on metabolic profiling.4 These include:

  • 1. Type 1, inflammatory (“hot”) Alzheimer’s: Patients present predominantly inflammatory symptoms. They have high-sensitivity C-reactive protein, interleukin 6 and tumor necrosis factor alpha, reflecting a chronic inflammatory state. When the NF-ĸB part of inflammation is activated, it also alters gene transcription. Two of the genes turned “on” are beta-secretase and gamma-secretase, the latter of which cleaves APP, thereby promoting synaptoclastic processes.
  • 2. Type 1.5, glycotoxic (sugar-toxic, “sweet, a mixed subtype: This is an in-between subtype that involves both inflammation and atrophy processes, due to insulin resistance and glucose-induced inflammation.
  • 3. Type 2, atrophic or “cold”Alzheimer’s: This is classified as patients presenting an atrophic response. While a completely different mechanism from inflammation, it produces the same end result — it pushes APP in the direction of creating amyloid plaques and Alzheimer’s cell signaling.
  • 4. Type 3, toxic (“vile”) Alzheimer’s: These are patients with toxic exposures. Many will have chronic inflammatory response syndrome (CIRS) markers, even though most do not fit the official criteria for CIRS. “They act like CIRS patients (in their labs, not necessarily symptoms) with dementia,” Bredesen explains.

Sections of the article include

  • If You’re ApoE4 Positive, Fasting Is Strongly Indicated to Avoid Alzheimer’s
  • Mitochondrial Dysfunction Is at the Heart of Alzheimer’s
  • The ReCODE protocol evaluates 150 different variables, including biochemistry, genetics and historical imaging, to determine which factors are most likely driving the disease.

Alzheimer’s Screening Tests

Test Recommended range
Ferritin 40 to 60 ng/mL
GGT <16 U/L for men and < 9 U/L for women
25-hydroxy vitamin D 40 to 60 ng/mL
High-sensitivity CRP <0.9 mg/L
Fasting Insulin < 4.5 mg/dL
Omega-3 index and
Omega 6:3 ratio
Omega-3 index > 8 %
TNF alpha < 6.0
TSH Less than 2.0 microunits/mL
Free T3 3.2-4.2 pg/mL
Reverse T3 <20 ng/mL
Free T4 1.3-1.8 ng/mL
Serum copper and zinc ratio 0.8-1.2
Serum selenium 110-150 ng/mL
Glutathione 5.0-5.5 μm
Vitamin E (alpha tocopherol) 12-20 mcg/mL
Body mass index 18-25
ApoE4 (DNA test) See how many alleles you have: 0, 1 or 2
Vitamin B12 500-1,500
Hemoglobin A1c Less than 5.5
Homocysteine 4.4-10.8 mcmol/L

See also VitaminDWiki

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

290 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014

See also web

Dale E. Bredesen as author or co-author

Created by admin. Last Modification: Sunday December 2, 2018 15:25:56 GMT-0000 by admin. (Version 18)

Attached files

ID Name Comment Uploaded Size Downloads
10958 Inhalational Alzheimer's disease.pdf admin 02 Dec, 2018 15:26 685.75 Kb 169
10957 Reversal of cognitive decline in Alzheimer's disease.pdf admin 02 Dec, 2018 15:18 528.97 Kb 167
8357 Alzheimer's B Vitamins.pdf PDF admin 27 Aug, 2017 14:37 852.72 Kb 243
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