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Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018

Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies

Nephrology Dialysis Transplantation, gfy016, https://doi.org/10.1093/ndt/gfy016
Yuhui Zhang Darsy Darssan Elaine M Pascoe David W Johnson Haichen Pi Jie Dong

VitaminDWiki

Kidney category starts with

Kidney category listing has 169 items

see also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 477 items as of Jan 2018
Search VitaminDWiki for kidney transplant 469 items as of Jan 2018
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 40 items along with related searches


Kidney Intervention trials using Vitamin D:

Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 169 items

 Download the PDF from VitaminDWiki

Background
Vitamin D deficiency is highly prevalent in patients on dialysis. Although vitamin D deficiency is closely associated with cardiovascular disease (CVD) and high mortality in the general population, the relationship between serum 25-hydroxyvitamin D [25(OH)D] and all-cause and cardiovascular mortality in dialysis patients is uncertain. We aim to explore the relationship between serum 25(OH)D levels and all-cause and cardiovascular mortality in dialysis patients.

Methods
This is a systematic review and meta-analysis of clinical studies among patients receiving maintenance dialysis. We did a systematic literature search in PubMed and Embase to identify studies reporting the relationship between serum 25(OH)D levels and all-cause and cardiovascular mortality in patients on dialysis. The search was last updated on 10 February 2017.

Results
The study included 18 moderate to high-quality cohort studies with an overall sample of 14 154 patients on dialysis. The relative risk of all-cause mortality per 10 ng/mL increase in serum 25(OH)D level was 0.78 [95% confidence interval (CI) 0.71–0.86], although there was marked heterogeneity (I2=96%, P < 0.01) that was partly explained by differences in CVD prevalence, baseline parathyroid hormone level and dialysis duration among included studies. The relative risk of cardiovascular mortality per 10 ng/mL increase in serum 25(OH)D level was 0.71 (95% CI 0.63–0.79), with substantial heterogeneity (I2=74%, P=0.004) that was largely explained by differences in study type and serum 25(OH)D measurement method.

Conclusions
In the present study, increased serum 25(OH)D level was significantly associated with lower all-cause mortality and lower cardiovascular mortality in dialysis patients.

Created by admin. Last Modification: Tuesday February 27, 2018 11:04:40 UTC by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
9416 dialysis meta-analysis.pdf PDF 2018 admin 27 Feb, 2018 10:59 654.00 Kb 58
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