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Diabetic nerve damage (Polyneuropathy) was 2.7 X more likely if low vitamin D, etc. – Dec 2019

Predictive Model of Diabetic Polyneuropathy Severity Based on Vitamin D Level

Macedonian Journal of Medical Sciences 2019 August 30, 7 (16): 2626-2629
Aida Fitri, Hasan Sjahrir, Adang Bachtiar, Muhammad Ichwan, Fasihah Irfani Fitri, Aldy Safruddin Rambe

VitaminDWiki

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 433 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

 Download the PDF from VitaminDWiki

BACKGROUND: Type 2 Diabetes Mellitus is one of the most common metabolic diseases worldwide. The most common complication of DM is diabetic neuropathy (DN), especially diabetic polyneuropathy (DPN). Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).

AIM: This study aimed to develop a predictive model of DPN severity based on vitamin D level.

METHODS: This was a prospective cohort study involving 50 subjects with DM which was conducted in Haji Adam Malik General Hospital Medan. All subjects were fulfilling inclusion criteria underwent laboratory examination to determine HbA1c and 25 (OH) D levels.
Predictive variables were

  • sex,
  • age,
  • duration of DM,
  • smoking status,
  • type and number of anti-diabetic drugs,
  • the presence of metabolic syndrome,
  • HbA1c and
  • vitamin D levels.

A scoring system was developed to determine a predictive model. The DPN severity was assessed using NCS and was re-evaluated after 3 months.

RESULTS: Most of the subjects were female (60%), belonged to ≥ 50 years old age-group (88%), with DM duration < 5 years (56%), were non-smoker (90%), we're using one anti-diabetic drug (60%), were using insulin (50%), had metabolic syndrome (68%), had HbA1c level > 6.5% (94%), and had vitamin D level < 20 ng/ml (56%). A score of > 4 on this predictive model of DPN severity had a relative risk (RR) of 2.70. The predictive model had a sensitivity of 82.8% and specificity of 61.9%.

CONCLUSION: A score of higher than 4 on this predictive model showed a 2.7 times higher risk of severe DPN. A predictive model of DPN severity based on vitamin D level had high sensitivity and specificity.

Created by admin. Last Modification: Monday December 2, 2019 12:46:28 GMT-0000 by admin. (Version 2)

Attached files

ID Name Comment Uploaded Size Downloads
13085 Diabetic Polyneuropathy.pdf PDF 2019 admin 02 Dec, 2019 12:45 178.69 Kb 0
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