2 meta-analyses on this page and links to many others
Effect of vitamin D supplementation on insulin resistance and glycaemic control in prediabetes: a systematic review and meta-analysis
N. Poolsup1, N. Suksomboon2,* andN. Plordplong2
Diabetic Medicine, DOI: 10.1111/dme.12893
Aims
To evaluate the effect of vitamin D on insulin resistance and glycaemic control in prediabetes.
Methods
A literature search was conducted of MEDLINE, the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, Web of Science and www.clinicaltrials.gov, together with a historical search through the reference lists of relevant articles until end of June 2014. Studies were included if they were randomized controlled trials of vitamin D or vitamin D analogues in prediabetes and if they reported homeostatic model assessment of insulin resistance or 2-h plasma glucose after oral glucose tolerance test. Treatment effect was estimated according to mean difference in the changes from baseline of homeostatic model assessment of insulin resistance, 2-h oral glucose tolerance test plasma glucose, fasting plasma glucose and HbA1c between vitamin D and control groups. Meta-analysis of eligible studies was performed.
Results
A total of 10 randomized controlled trials were included. Vitamin D did not significantly improve homeostatic model assessment of insulin resistance and 2-h oral glucose tolerance test plasma glucose: the mean differences were -0.06 (95% CI -0.36 to 0.24) and -0.23 mmol/l (95% CI -0.65 to 0.19), respectively. Subgroup analysis suggested that vitamin D improved homeostatic model assessment of insulin resistance in a subgroup with baseline 25-hydroxyvitamin D ≥ 50 nmol/l [mean difference -0.59 (95% CI -1.14 to -0.04); P=0.03] and improved 2-h oral glucose tolerance test plasma glucose in the subgroup with baseline 25-hydroxyvitamin D < 50 nmol/l [mean difference -0.68 mmol/l (95% CI -1.35 to -0.01); P=0.05]. Vitamin D significantly reduced fasting plasma glucose and HbA1c levels. The mean differences were -0.10 mmol/l (95% CI -0.18 to -0.03), P=0.006 and -1 mmol/mol (95% CI -2 to 0), P=0.008, respectively.
Conclusions
No beneficial effect of vitamin D in improving insulin resistance was identified.
Publisher wants $6 for the PDF
The above meta-analysis gave same weight to studies using tiny amounts of Vitamin D as studies which used a pharmacologically sufficient amount of Vitamin D
Another Diabetes Meta-analysis in 2016 ignored
- How much vitamin D was taken
- The total amount of vitamin D taken
- The increase in blood levels of vitamin D which resulted
The effect of vitamin D supplementation on glycaemic control in patients with Type 2 Diabetes Mellitus: a systematic review and meta-analysis
 Download the PDF from VitaminDWiki
See also VitaminDWiki
The Meta-analysis of Diabetes and Vitamin D are listed here:
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021
- Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis May 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Diabetic Foot Ulcer 3.2 X or 3.6 X more likely if low vitamin D – several meta-analyses
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis Jan 2018
- Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken) – Sept 2015
- Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis Dec 2014
- Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Diabetes down 13 percent if more than 500 IU of vitamin D – meta-analysis July 2011