J Dev Orig Health Dis. 2015 Oct 27:1-6. [Epub ahead of print]
Jacobsen R1, Moldovan M2, Vaag AA3, Hypponen E2, Heitmann BL1.
1 Research Unit for Dietary Studies, The Parker Institute, Frederiksberg Hospital, Frederiksberg, Denmark.
2 School of Population Health, University of South Australia, Adelaide, Australia.
3 Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
Fortification of margarine with vitamin D was mandatory in Denmark during 1961-1985. The aim of the study was to assess whether gestational and early infancy exposure to margarine fortification was associated with seasonality of birth in Danish type 1 diabetes (T1D) patients. The risks of T1D in Danes born during various exposure periods around margarine fortification termination in 1985 were analyzed.
As expected, the T1D hazards in males unexposed to margarine fortification and born in spring were higher than in males born in autumn: relevant hazard ratios (95% confidence intervals) in various exposure groups ranged from 1.74 (1.112/2.708) to 37.43 (1.804/776.558).
There were no indications of seasonality of birth in males exposed to fortification, nor in both exposed and unexposed females. The study suggests that early life exposure to low-dose vitamin D from fortified food eliminates seasonality of birth in T1D male patients. Further studies are required to investigate the identified gender differences.
How much vitamin D in was in the margarine?
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which are just some of the vitamin D cofactors
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