Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study
Annals of Medicine, Vol 50, 2018 - # 1, Pages 74-82, https://doi.org/10.1080/07853890.2017.1399446
Feitong Wu ORCID Icon, Markus Juonala, Niina Pitkänen, Antti Jula, Terho Lehtimäki, Matthew A. Sabin,
31 year study of 2,300 people in Finland
Keeping vitamin D above 25 ng from age 3-18 resulted in Type 2 Diabetes risk cut in half
- Can Vitamin D treat Diabetes - many articles
- Diabetes treated by vitamin D when levels exceeded 61 ng – Sept 2015
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- Diabetic blacks – 80 percent had low vitamin D (less than 20 ng) a decade before – Sept 2017
Founder of VitaminDWiki supplements with Vitamin D + Magnesium + Omega-3
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Type 2 Diabetes helped by Omega-3 and Vitamin D – Feb 2014
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
430 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Diabetes category starts with the following
430 items In Diabetes category Autoimmune category listing has 151 items along with related searches
Values are odds ratio (95% confidence interval) unless otherwise stated.
NFG: normal fasting glucose; IFG: impaired fasting glucose (cut-off 5.6mmol/L)
a Reference group for the outcome comparison.
bp < .1. Bold values denote statistical significance, p < .05.
- Model 1: unadjusted;
- Model 2: adjusted for age, sex, body mass index, month of blood taken, parental history of diabetes and fruit consumption;
- Model 3: model 2 + physical activity, smoking, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, insulin, vegetable consumption, socioeconomic status (the parental length of time spent in education).
- Model 4: model 3 + adult body mass index (missing data of adult body mass index were imputed for 25 participants).
Objectives: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood.
Materials and methods: This was a 31-year follow-up study of 2300 participants aged 3–18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life.
Results: High serum 25OHD levels in youth and also mean values from youth to adulthood were associated with reduced risk of developing T2DM in adulthood (odds ratio, 95% confidence interval= 0.73, 0.57–0.95 and 0.65, 0.51–0.84, respectively, for each SD increment in 25OHD). Compared to Q1, a dose-dependent negative association was observed across other quartiles of youth 25OHD, while the strongest association was found in the Q3 for the mean 25OHD levels. Neither youth nor the mean 25OHD was associated with IFG.
Conclusions: High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood.
- High serum 25OHD levels in youth, and between youth and adulthood, were associated with a lower risk of T2DM in adulthood.
- Each SD (15.2 nmol/L) increment in youth serum 25OHD levels was associated with a 26% reduction in odds for T2DM, which was independent of a number of confounding variables and other risk factors for T2DM. A similar magnitude of association was observed for the long-term 25OHD levels between youth and adulthood.
- These findings suggest a potentially simple and cost-effective strategy for reducing adulthood risk of T2DM starting in an earlier stage of life – improving and maintaining vitamin D status throughout youth and early adulthood.