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Diabetes (T2DM) half as likely if keep Vitamin D above 25 ng as a youth – Jan 2018

Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study

Annals of Medicine, Vol 50, 2018 - # 1, Pages 74-82, https://doi.org/10.1080/07853890.2017.1399446
Feitong Wu ORCID Icon, Markus Juonala, Niina Pitkänen, Antti Jula, Terho Lehtimäki, Matthew A. Sabin,

VitaminDWiki

31 year study of 2,300 people in Finland
Keeping vitamin D above 25 ng from age 3-18 resulted in Type 2 Diabetes risk cut in half


Founder of VitaminDWiki supplements with Vitamin D + Magnesium + Omega-3

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 366 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Diabetes category starts with the following

366 items In Diabetes category

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 106 items along with related searches

T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018

 Download the PDF from Sci-Hub via VitaminDWiki

Image
Values are odds ratio (95% confidence interval) unless otherwise stated.
NFG: normal fasting glucose; IFG: impaired fasting glucose (cut-off 5.6mmol/L)
a Reference group for the outcome comparison.
bp < .1. Bold values denote statistical significance, p < .05.

  • Model 1: unadjusted;
  • Model 2: adjusted for age, sex, body mass index, month of blood taken, parental history of diabetes and fruit consumption;
  • Model 3: model 2 + physical activity, smoking, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, insulin, vegetable consumption, socioeconomic status (the parental length of time spent in education).
  • Model 4: model 3 + adult body mass index (missing data of adult body mass index were imputed for 25 participants).


Objectives: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood.

Materials and methods: This was a 31-year follow-up study of 2300 participants aged 3–18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life.

Results: High serum 25OHD levels in youth and also mean values from youth to adulthood were associated with reduced risk of developing T2DM in adulthood (odds ratio, 95% confidence interval= 0.73, 0.57–0.95 and 0.65, 0.51–0.84, respectively, for each SD increment in 25OHD). Compared to Q1, a dose-dependent negative association was observed across other quartiles of youth 25OHD, while the strongest association was found in the Q3 for the mean 25OHD levels. Neither youth nor the mean 25OHD was associated with IFG.

Conclusions: High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood.

Key Messages

  • High serum 25OHD levels in youth, and between youth and adulthood, were associated with a lower risk of T2DM in adulthood.
  • Each SD (15.2 nmol/L) increment in youth serum 25OHD levels was associated with a 26% reduction in odds for T2DM, which was independent of a number of confounding variables and other risk factors for T2DM. A similar magnitude of association was observed for the long-term 25OHD levels between youth and adulthood.
  • These findings suggest a potentially simple and cost-effective strategy for reducing adulthood risk of T2DM starting in an earlier stage of life – improving and maintaining vitamin D status throughout youth and early adulthood.
Created by admin. Last Modification: Tuesday February 6, 2018 12:10:50 UTC by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
9315 T2DM high Vitamin D.jpg admin 06 Feb, 2018 12:03 75.91 Kb 55
9314 Good Vit D for decade less risk of diabetes.pdf PDF 2018 admin 06 Feb, 2018 12:02 1.09 Mb 27
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