Assoc. Med. Bras. 67 (8) • Aug 2021 • https://doi.org/10.1590/1806-9282.20210404
Raphaele Teixeira MoreiraLays Arnaud Rosal Lopes RodriguesLuciana Melo de FariasJany de Moura CrisóstomoLayanne Cristina de Carvalho LavôrOnias de Sousa Rodrigues FilhoKaroline de Macêdo Gonçalves Frota
Without being proceeded by a loading dose ,vitamin D rarely provided a benefit in less than 12 weeks
The daily average dosing typically muct be >2,000 IU to have any hope of providing a benefit
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022
- Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case) – July 2021
- Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT Feb 2020
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D - no cure for depression (when you use only 1200 IU) – Aug 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation – Feb 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013
- Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Depression reduced if use more than 2,800 IU of vitamin D – meta-analysis Aug 2022
- Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses July 2022
- Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Depression is associated with low Magnesium – meta-analysis April 2015
- Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
- Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis – Nov 2014
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- Low vitamin D and depression - Study and meta-analysis, April 2013
- 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis Jan 2013
- Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
- Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
- Seasonal Affective Disorder is treated by both bright light and Vitamin D because both make serotonin
- Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
- Omega-3, Magnesium, and St. Johns' Wort also decrease depression
- Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
- Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
- Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
- There are
254 items in the Depression category in VitaminDWiki
Depression is a mental disorder that has drawn attention because of its high incidence. The World Health Organization (WHO) reported that the number of cases of depression increased by 18% between 2005 and 2015; 322 million people have depression globally, and most of them are women. In Brazil, depression affects 11.5 million people (5.8% of the population)1.
Depression is characterized by the impairment of the physical and mental states of an individual. Its main symptoms are constant sadness, lack of energy, irritability, anxiety, and loss of interest in activities that usually produce a feeling of pleasure, low self-esteem, and changes in sleep and appetite. For the diagnosis of depression, symptoms should persist for at least 2 weeks2,3.
Depression is also associated with serious disabilities, mortality, and medical expenses. Despite the development of biological, psychological, and environmental theories, the underlying pathophysiology of depression is still unknown and may involve several mechanisms4,5.
There has been a long-standing interest in the role of nutrition and its relationship to depression; some studies have shown a strong relationship between vitamin D and depression. Several dietary factors have been implicated in the development and treatment of depression. The changes in vitamin D receptors impact several brain neurotransmitters and, therefore, suggest a potential role of vitamin D in causing and correcting mood disorders6.
Vitamin D is involved in several brain processes, including neuroimmune regulation, neurotrophic factor regulation, neuroprotection, neuroplasticity, and brain development. Therefore, biologically speaking, this vitamin may be related to depression, and its supplementation may play an important role in the treatment of the disease7,8. Therefore, this study aimed to review the recent literature on the effect of vitamin D supplementation in the treatment of patients with depression.
A systematic review of vitamin D supplementation in patients with depression was performed. For the guiding question, the PICO strategy was used, which represents the population (P) to be studied, the intervention (I), comparison (C), and outcome (O). The question to be raised was whether vitamin D supplementation, compared with placebo, helps in the treatment of patients with depression. Each PICO item represents an element: (P) patients with depression, (I) vitamin D supplementation, (C) placebo, and (O) improvements in patient health.
The review was carried out from September to December 2020 and included all articles published up to the time of the research retrieved from the PubMed, SciELO, and ScienceDirect databases. The following combination of descriptors was used in the search for articles: supplementation and (depression or depressive symptoms) and vitamin D registered in the Medical Subject Headings.
Original articles and randomized (RCTs) and placebo-controlled clinical trials addressing vitamin D supplementation in patients with depression with different clinical conditions and at different ages were included. Duplicate original articles and articles that could not be accessed were excluded. The research was registered with the Research Coordination of the UNINOVAFAPI University Center under case number 104/2020.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was used to ensure the quality of this study. For the quantitative analysis and risk of methodological bias, the Jadad scale was used to classify articles from 0 to 5 based on the methodological criteria and adequacy of results, and the Cochrane collaboration tool was used to classify articles with a low risk of bias, high risk of bias, and uncertain risk of bias.
The bibliographic research, according to the pre-established strategy, resulted in 830 articles. Of these, 46 were from the PubMed database, 784 were from ScienceDirect, and 0 were from SciELO. After the duplicate article selection and removal process, six original RCTs were identified as eligible for this systematic review. Figure 1 shows the flowchart of the search results for the sources of information and the selection and inclusion of original articles in the systematic review, according to the PRISMA protocol.Depression is treated by vitamin D (when enough is given) – review Oct 2021
1398 visitors, last modified 21 Oct, 2021,This page is in the following categories (# of items in each category)