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Coronaviruses attach to cells via ACE2, which is reduced by Vitamin D


Fact All Coronavirus attach to ACE2 enzyme in human cells
Fact Vitamin D reduces ACE2 enzyme
Fact All previous human Coronavirus are fought by Vitamin D
Suspect Vitamin D will also fight the new form of Coronavirus, COVID-19


SARS and the new coronavirus target the same cellular lock to infect cells

  • “When cells had the ACE2 protein on their surface, the virus was able to break into them.”

 Download the study from VitaminDWiki


Can a Database of Animal Viruses Help Predict the Next Pandemic?

Wired Magazine Feb 12 2020
Several studies confirmed that Wuhan Coronovirus uses ACE2 connection

  • "... January 23, a research group from Wuhan’s Institute of Virology reported they had tested live samples of the new virus against human cell lines expressing ACE2 proteins and those without ACE2. It could only infect the ones that carried the receptor."

Vitamin D 3rd edition - 2011

Chapter 40 - Vitamin D and the Renin-Angiotensin System. https://doi.org/10.1016/B978-0-12-381978-9.10040-X
 Download the PDF from Sci-Hub via VitaminDWiki
Image


Search Google Scholar for ACE2 and "Vitamin D" 1062 studies as of Feb 2020


Wonder if the other human coronaviruses also connect to cells via ACE2

1) Human coronavirus 229E (HCoV-229E)
2) Human coronavirus OC43 (HCoV-OC43)
3) Human coronavirus NL63 (HCoV-NL63, New Haven coronavirus)
4) Human coronavirus HKU1
Entry of Human Coronavirus NL63 Into the Cell - Jan 2018
 Download the PDF from VitaminDWiki


Vitamin D alleviates lipopolysaccharide‑induced acute lung injury via regulation of the renin‑angiotensin system - 2017

  • From Discussion: "The mRNA expression levels of ACE and ACE2 in NT, LPS and LPS + calcitriol-treated lung tissues were also determined, and the results demonstrated that LPS increased ACE expression and decreased ACE2 levels compared with the NT group. Calcitriol treatment inhibited the effects of LPS on ACE and ACE2 mRNA expression "

 Download the PDF from VitaminDWiki


Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus -2003

 Download the PDF from VitaminDWiki


Archive of preprints for Medical Studies (which have NOT been peer reviewed) - on Cononavirus and ACE2

73 papers on Coronavirus as of Feb 19, 2020
14 concerned Coronavirus AND ACE2 note that the date of the publication is embedded in the URL

Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV, in the nasal tissue   PDF https://www.medrxiv.org/content/10.1101/2020.02.11.20022228v2
Laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections https://www.medrxiv.org/content/10.1101/2020.02.11.20021493v1
ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection https://www.medrxiv.org/content/10.1101/2020.02.12.20022418v1
Tobacco-use disparity in gene expression of ACE2, the receptor of 2019-nCov https://www.medrxiv.org/content/10.1101/2020.02.05.20020107v1
Assessing the plausibility of subcritical transmission of 2019-nCoV in the United States https://www.medrxiv.org/content/10.1101/2020.02.08.20021311v1
Diarrhea may be underestimated: a missing link in 2019 novel coronavirus https://www.medrxiv.org/content/10.1101/2020.02.03.20020289v1

42 minute YouTube video concerning Vitamin D, Coronavirus and ACE2

Slides are in German, but they are described by the author in English
ACE2 controls blood pressure.
When the Coronavirus takes over the ACE2, the blood pressure rises (in the lungs)
Video also overviews many previous Vitamin D studies on respiratory viruses
Death from pulmonary edema after infection with the coronavirus is due to its use of the ACE2 protein as virus receptor- Feb 14, 2020


VitaminDWiki

10 most recently added items in Virus Category


  • ACE2 in Wikipedia
    • Two separate sets of researchers have asserted that the entry point is the same for the Novel coronavirus (SARS-CoV-2) (Feb 14)

short URL = https://is.gd/CoronaACE2


Attached files

ID Name Comment Uploaded Size Downloads
13512 ACE2, the putative receptor of Wuhan.pdf PDF 2020 admin 19 Feb, 2020 16:18 672.25 Kb 3
13452 Renin-angiotensin sys, vit D acute lung injury Xu.pdf admin 05 Feb, 2020 03:24 1.08 Mb 40
13451 ACE2 SARS receptor Li Nature 2003.pdf admin 05 Feb, 2020 03:20 1.90 Mb 24
13450 NL63.pdf admin 05 Feb, 2020 00:05 3.80 Mb 23
13449 2011.pdf admin 04 Feb, 2020 23:45 889.88 Kb 68
13448 Renin-Angiotension.jpg admin 04 Feb, 2020 23:41 20.82 Kb 664
13447 coronavirus ACE2.pdf PDF 2020 admin 04 Feb, 2020 23:25 1.08 Mb 82
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