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Cooked dried beans or peas (pulses) reduce uptake of Vitamin D, Vitamin K by half – March 2019

The Presence of Pulses within a Meal can Alter Fat-Soluble Vitamin Bioavailability.

Mol Nutr Food Res. 2019 Mar 28:e1801323. doi: 10.1002/mnfr.201801323.
Margier M1, Antoine T 1, Siriaco A 1, Nowicki M 1, Halimi C 1, Maillot M 2, Georgé S 3, Reboul E 1 Emmanuelle.Reboul at univ-amu.fr
1 INSERM, Aix Marseille Univ, C2VN, Marseille, France.
2 MS-Nutrition, Marseille, France.
3 CTCPA, Avignon.


This study analyzed Vitamin uptake in an artificial intestine
Founder of VitaminDWiki does not recall seeing that pulses restrict
   the uptake of Vitamin D or Vitamin K
Wonder if pulses limit Vit D, Vit K in the real gut as well
The vitamins they tested were in olive oil
Suspect increased uptake if micelle or emulsion forms of Vitamins had been used instead
If this study is correct, oil-based Vitamin D should NOT be taken with a pulse meal

See also web

  • https://pulses.org/what-are-pulses
  • 10 things about Beans BlueZones
    • 4X more protein than from meat for the same cost
    • Beans are the only food that can fit into both a vegetable and a protein category,
  • Pulses in diet reduced lipids - meta-analysis - May 2014
    "Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials"
     Download the PDF from VitaminDWiki
  • Calories consumed in Brazil: 13% from pulses

Note: no references in Google Scholar to this study as of Oc 2019

 Download the PDF from Sci-Hub via VitaminDWiki

Wonder that a, b mean? - could not quickly find in the PDF

It is widely advised to increase pulse consumption. However, pulses are rich in molecules displaying lipid-lowering properties, including fibers, phytates, saponins and tannins. We thus explored the effects of pulses on fat-soluble vitamin bioavailability.

We assessed vitamin A (β-carotene and retinyl-palmitate), vitamin E (α-tocopherol), vitamin D (cholecalciferol) and vitamin K (phylloquinone) bioaccessibility, i.e. micellarization after in vitro digestion of meals containing either potatoes (control), household-cooked or canned pulses. The obtained mixed micelles were delivered to Caco-2 cells to evaluate vitamin uptake. We then specifically assessed the impact of fibers, phytates, saponins and tannins on both phylloquinone (used as a model vitamin) bioaccessibility and uptake.

The presence of pulses significantly decreased both vitamin
bioaccessibility (up to

  • -65% for β-carotene,
  • -69% for retinyl-palmitate,
  • -45% for cholecalciferol,
  • - 53% for α-tocopherol and
  • -67% for phylloquinone) and

uptake (

  • -40% for retinyl-palmitate,
  • -67% for cholecalciferol,
  • -50% for α-tocopherol and
  • -57% for phylloquinone).

Effects on bioaccessibility, but not on uptake, were dependent on pulse cooking method. Phylloquinone bioaccessibility was specifically impacted by saponins, tannins and fibers while its uptake was impacted by saponins, fibers and phytates.

Pulses can alter fat-soluble micronutrient bioavailability. Pulses should thus be cooked appropriately and consumed within micronutrient-rich meals. This article is protected by copyright. All rights reserved.

Clipped from PDF

  • "It has also been shown that regular consumption of pulses can lead to decreased plasma cholesterol and triglyceride levels [14], suggesting an impact on lipid absorption and/or metabolism. This impact is likely due to pulse fiber content [15], but other pulse bioactive compounds such as phytates, saponins or polyphenols may also play important roles in this phenomenon [13]"
  • "Fat-soluble vitamin bioaccessibility and uptake are negatively correlated to the presence of fibers, phytates, saponins or tannins"
  • "Pulses components are acknowledged to impair mineral bioavailability [27], as well as to reduce lipid absorption 14"


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Attached files

ID Name Comment Uploaded Size Downloads
11696 nutrients-09-01152.pdf admin 31 Mar, 2019 00:25 1.19 Mb 478
11693 pulse intake on established therapeutic lipid targets.pdf admin 29 Mar, 2019 23:19 380.90 Kb 477
11690 Pulses Brazil.jpg admin 29 Mar, 2019 16:43 80.70 Kb 1141
11689 Pulses chart.jpg admin 29 Mar, 2019 12:18 45.82 Kb 957
11687 Pulses.jpg admin 29 Mar, 2019 11:08 61.85 Kb 1305
11686 Pulses.pdf PDF 2019 admin 29 Mar, 2019 11:07 1.19 Mb 533
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