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Complement system (part of innate immunity) needs Vitamin D (50 ng is good) – Sept 2022


Vitamin D deficiency leads to the abnormal activation of the complement system

Immunol Res. 2022 Sep 30. doi: 10.1007/s12026-022-09324-6
Huan Li # 1 , Xiaomin Xie # 2 , Guirong Bai 1 , Dan Qiang 1 , Li Zhang 1 , Huili Liu 1 , Yanting He 1 , Yanpan Tang 1 , Ling Li 1

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Vitamin D deficiency can damage the human immune system, and the complement system is a key component of the immune system. This study aimed to elucidate the mechanism by which vitamin D affects the immune system by analyzing the changes in the protein expression of the complement system under different vitamin D levels. We selected 40 participants and divided them into three groups according to their serum levels of 25-hydroxyvitamin D (25(OH)VD):

  • group A, 25(OH)VD ≥ 40 ng/mL;
  • group B, 30 ng/mL ≤ 25(OH)VD < 40 ng/mL; and
  • group C, 25(OH)VD < 30 ng/mL.

Serum samples were subjected to biochemical analysis, followed by proteomic analysis using high-throughput untargeted proteomic techniques. Vitamin D deficiency increased the levels of fasting blood sugar, fasting serum insulin, and homeostasis model assessment (HOMA) of insulin resistance and decreased the secretion of HOMA of β-cell function, which led to insulin resistance and glucose metabolism disorder. Moreover, vitamin D deficiency resulted in the abnormal expression of 56 differential proteins, among which the expression levels of complement factor B, complement component C9, inducible co-stimulator ligand, and peptidase inhibitor 16 significantly changed with the decrease in vitamin D content. Functional enrichment analysis of these differential proteins showed that they were mainly concentrated in functions and pathways related to insulin secretion and inflammation.

In conclusion, vitamin D deficiency not only contributes to insulin resistance and glucose metabolism disorder but also causes abnormal protein expression, resulting in the abnormal activation of the complement system. This study provides a novel theoretical basis for further studies on the relationship between vitamin D and the immune system.

Clipped from PDF
In conclusion, the main findings of this study were as follows:

  • (1) vitamin D deficiency caused insulin resistance and glucose metabolism disorder,
  • (2) vitamin D deficiency led to the abnormal expression of complement proteins and the activation of the complement system, and
  • (3) functional enrichment analysis revealed that dysregulated complement proteins were involved in cellular functions related to insulin `secretion and glucose metabolism regulation.

This study provides a novel reference for further studies on the regulatory effect of vitamin D on the immune system.
 Download the PDF from VitaminDWiki


Complement system Wikipedia Sept 2022

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system,[1] which is not adaptable and does not change during an individual's lifetime.
The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
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VitaminDWiki - Immunity category contains

263 items in Immunity category

    see also

Virus category listing has 1363 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D

18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
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48 studies are in both Immunity and Virus categories

VitaminDWiki pages with INNATE in title (14 as of Sept 2022)

This list is automatically updated

Items found: 14

VitaminDWiki - Is 50 ng of vitamin D too high, just right, or not enough


VitaminDWiki pages with 50 ng in title (60 as of Sept 2022)

This list is automatically updated

Items found: 82
Title Modified
All myopic children had less than 50 ng of vitamin D – March 2016 06 Apr, 2017
A group of 6,000 people have vitamin D levels higher than 50 ng – GrassrootsHealth 29 Jun, 2016
Populations with more than 50 ng of vitamin D 09 Apr, 2016
Staph infection reduced 50 percent when have more than 30 ng of vitamin D – Aug 2011 13 Feb, 2016
Outdoor distance runners had great Vitamin D levels (50 ng) – Dec 2015 24 Dec, 2015
Asthma at age 20 increased if vitamin D during pregnancy was higher than 50 ng – Oct 2015 04 Nov, 2015
Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012 29 Sep, 2015
Vitamin D more than 40 ng: 1300 IU 50% chance: 5,000 IU 80% chance - Aug 2014 13 Sep, 2015
Many more people now have vitamin D levels above 50 ng, especially seniors – May 2015 20 Jun, 2015
Vitamin D video: calcification, narrow-band UV, 4,000 IU, 50 ng – Dr. DeLuca May 2015 04 Jun, 2015
50 percent more elderly deaths when vitamin D under 18 ng or over 40 ng – Aug 2010 31 May, 2015
Dr. Oz recommends at least 50 ng of vitamin D 20 Mar, 2015
Dr Oz: 50ng of vitamin D - Nov 2009 20 Mar, 2015
Smoking associated with 9 ng less vitamin D age 40-50 – Nov 2014 24 Nov, 2014
Semen worse when vitamin D lower than 20 or higher than 50 ng – Oct 2012 16 Oct, 2014
Fertility in both women and men improves with more vitamin D (but less than 50 ng for men) – Dec 2013 16 Oct, 2014
Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012 23 Sep, 2014
5000 IU vitamin D3 added daily to bread raised blood levels to 50 ng – 2009 16 May, 2014
Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014 24 Mar, 2014
Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation – Jan 2014 29 Jan, 2014
Dr. Oz again recommends at least 50 ng of vitamin D - Dec 2013 05 Jan, 2014
50,000 IU of vitamin D monthly in winter gets most above 20 ng – RCT Nov 2013 21 Dec, 2013
Dr Oz recommends 50 ng vitamin D blood level 03 Dec, 2013
50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013 13 Nov, 2013
At least 5,000 IU Vitamin D to get to optimal 50 ng - LEF Nov 2013 11 Nov, 2013
30 to 50 ng of vitamin D is optimal – Central Europe consensus Sept 2013 23 Sep, 2013
European Osteo group recommends 20-50 ng of vitamin D – Jan 2013 17 Jan, 2013
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Metabolic syndrome 50 percent more likely if under 20 ng of vitamin D - May 2011 23 Jun, 2012
USANA found 5000 IU resulted in 50 ng - Winter 2010 24 Sep, 2011
Vitamin D level of 50 ng may be too high - May 2010 24 Sep, 2011
Athletes need 50 ng/ml of Vitamin D – Cannell and Hollis – 2009 02 Jul, 2011
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Web

Complement system part I – molecular mechanisms of activation and regulation - 2015 PDF
Complement system part II - 2015 PDF
   No mention of vitamin in either one


PDF References

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Created by admin. Last Modification: Saturday October 1, 2022 17:51:09 GMT-0000 by admin. (Version 15)

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