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Cognitive impairment after stroke increased if Vitamin D deficient - Dec 2018

Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study.

Clin Interv Aging. 2018 Dec 10;13:2503-2509. doi: 10.2147/CIA.S187142. eCollection 2018.
Chen H1, Liu Y1, Huang G1, Zhu J2, Feng W2, He J1.

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VDD is < 10 ng

OBJECTIVE:
Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month.

METHODS:
In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels.

RESULTS:
According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients.

CONCLUSION:
Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment.

Attached files

ID Name Comment Uploaded Size Downloads
11091 Stroke cognition.jpg admin 25 Dec, 2018 12:44 24.58 Kb 75
11090 Cognition after stroke.pdf PDF 2018 admin 25 Dec, 2018 12:44 542.13 Kb 54
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