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Chronic pain 40 percent less intense associated with 10 nanogram more vitamin D – April 2014

Vitamin D and Central Hypersensitivity in Patients with Chronic Pain

Pain Medicine DOI: 10.1111/pme.12454
Roland von Känel MD1,2,*, Veronika Müller-Hartmannsgruber MD1, Georgios Kokinogenis MD1 andNiklaus Egloff MD1,2
1Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
2Department of Clinical Research, University of Bern, Bern, Switzerland
*Reprint requests to: Roland von Känel, MD, Department of General Internal Medicine, Inselspital, Bern University Hospital, CH-3010, Bern, Switzerland. Tel: +41 31 632 20 19; Fax: +41 (0)31 382 11 84; E-mail: roland.vonkaenel at insel.ch.

Background
Low vitamin D is implicated in various chronic pain conditions with, however, inconclusive findings. Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.

Objective
This study aims to examine the relation between low serum levels of 25-hydroxyvitamin D3 (25-OH D) and mechanical pain sensitivity.

Design
We studied 174 patients (mean age 48 years, 53% women) with chronic pain. A standardized pain provocation test was applied, and pain intensity was rated on a numerical analogue scale (0–10). The widespread pain index and symptom severity score (including fatigue, waking unrefreshed, and cognitive symptoms) following the 2010 American College of Rheumatology preliminary diagnostic criteria for fibromyalgia were also assessed. Serum 25-OH D levels were measured with a chemiluminescent immunoassay.

Results
Vitamin deficiency (25-OH D < 50 nmol/L) was present in 71% of chronic pain patients; another 21% had insufficient vitamin D (25-OH D < 75 nmol/L). After adjustment for demographic and clinical variables, there was a mean ± standard error of the mean increase in pain intensity of 0.61 ± 0.25 for each 25 nmol/L decrease in 25-OH D (P = 0.011). Lower 25-OH D levels were also related to greater symptom severity (r = −0.21, P = 0.008) but not to the widespread pain index (P = 0.83) and fibromyalgia (P = 0.51).

Conclusions
The findings suggest a role of low vitamin D levels for heightened central sensitivity, particularly augmented pain processing upon mechanical stimulation in chronic pain patients. Vitamin D seems comparably less important for self-reports of spontaneous chronic pain.


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Approximately 0.6 increase of pain sensitivity for 10 ng/mL lower vitamin D level

an example of a visual pain scale chart
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IF increasing vitamin D can reduce pain sensitivity, then an increase of about 30 ng would be needed to make a significant difference (2 units)

See also VitaminDWiki

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Results of a survey of people taking vitamin D was similar - more pain if less vitamin D

April 2013 Unpublished results from www.grassrootshealth.net/index.php/documentation
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