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Chronic Pain reported 38 percent less often if supplemented with Vitamin D – meta-analysis Sept 2016

Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis.

Pain Physician. 2016 Sep-Oct;19(7):415-427.
Wu Z1, Malihi Z1, Stewart AW1, Lawes CM1, Scragg R1.
1University of Auckland Epidemiology and Biostatistics New Zealand.


This meta-analysis averaged the benefits over a wide range of dose sizes
Most likely they would have found far more benefit it they had ignored trials using < 2,500 IU of vitamin D

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Pain - chronic category has the following

159 items in category Chronic pain

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BACKGROUND: There is conflicting evidence from previous qualitative reviews on the effect of vitamin D supplementation on pain.

OBJECTIVE: To determine with quantitative methods if vitamin D supplementation lowers pain levels.

STUDY DESIGN: Quantitative meta-analysis of published randomized controlled trials (RCTs).

SETTING: This meta-analysis examined all studies involving the effect of vitamin D supplementation on pain score.

METHOD: Electronic sources (Medline, Embase, Cochrane Central Register of Controlled Trials, clinical trials website, and Google scholar) were systematically searched for RCTs of vitamin D supplementation and pain from inception of each database to October 2015.

Nineteen RCTs with 3,436 participants (1,780 on vitamin D supplementation and 1,656 on placebo) were included in the meta-analysis. For the primary outcome (mean change in pain score from baseline to final follow-up), 8 trials with 1,222 participants on vitamin D and 1,235 on placebo reported a significantly greater mean decrease in pain score for the vitamin D group compared to placebo (mean difference -0.57, 95% CI: -1.00 to -0.15, P = 0.007).
The effect from vitamin D was greater in patients recruited with pre-existing pain (P-value for interaction = 0.03).
Fourteen studies (1,548 on vitamin D, 1,430 on placebo) reported the mean pain score at final follow-up outcome, and no statistical difference was observed (mean difference -0.06, 95%CI: -0.44 to 0.33, P = 0.78).
In 4 studies which reported pain improvement (209 on vitamin D, 146 on placebo), the effect size although not significant, shows participants in the vitamin D supplementation group were more likely to report pain improvement compared with the placebo group (relative risk 1.38, 95%CI: 0.93 to 2.05, P = 0.11).

LIMITATIONS: Only a few studies reported the mean score change from baseline to final follow-up, and we do not have enough data to determine any modifying effect of baseline vitamin D status and different doses of vitamin D supplementation on pain.

CONCLUSION: A significantly greater mean decrease in pain score (primary outcome) was observed with vitamin D supplementation compared with placebo in people with chronic pain. These results suggest that vitamin D supplementation could have a role in the management of chronic pain.

Attached files

ID Name Comment Uploaded Size Downloads
7124 Pain 1.jpg admin 01 Oct, 2016 175.57 Kb 1660
7123 Pain continued.jpg admin 01 Oct, 2016 106.15 Kb 1378
7122 Pain meta-analysis.jpg admin 01 Oct, 2016 168.33 Kb 806
7113 Pain Meta.pdf admin 28 Sep, 2016 919.85 Kb 1563