Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults.
Br J Nutr. 2011 Sep 8:1-7.
Zhao G, Ford ES, Tsai J, Li C, Croft JB.
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K67, Atlanta, GA 30341, USA.
Increasing evidence suggests that vitamin D benefits both innate and adaptive immunity, thereby eliciting an anti-inflammatory effect and reducing the risk of infectious disease. The present study examined the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of chronic bronchitis among US adults. We analysed data from 6872 US adults aged ? 20 years who participated in the 2003-6 National Health and Nutrition Examination Survey. Prevalence and OR with 95 % CI of having self-reported chronic bronchitis were estimated by quintiles of 25(OH)D or vitamin D-deficiency status after adjustment for potential confounders.
The results showed that the adjusted prevalence of chronic bronchitis ranged from 2·4 (95 % CI 1·4, 3·3) % among adults in the highest quintile of 25(OH)D ( ? 30 ng/ml) to 4·1 (95 % CI 2·5, 5·6) % among adults in the lowest quintile ( < 15 ng/ml; P for trend < 0·01). The adjusted OR for chronic bronchitis was 1·85 (95 % CI 1·06, 3·24) in adults with < 15 ng/ml 25(OH)D and 1·77 (95 % CI 1·19, 2·65) in those with 15 to < 20 ng/ml 25(OH)D compared with adults with ? 30 ng/ml 25(OH)D. Additionally, the adjusted OR for chronic bronchitis was 1·52 (95 % CI 1·03, 2·26) among adults with vitamin D deficiency ( < 20 ng/ml 25(OH)D) compared with those with ? 20 ng/ml 25(OH)D.
For every 1 ng/ml increase in 25(OH)D, the likelihood of having chronic bronchitis fell by 2·6 % (P = 0·016). In conclusion, low serum 25(OH)D levels are associated with the increased risk of chronic bronchitis among US adults. The present results provide support for continuing research on the role of vitamin D in lung diseases.
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Most people who have COPDhave both emphysema and chronic obstructive bronchitis.
Thus, the general term "COPD" is more accurate.
COPD is a major cause of disability, and it's the third leading cause of death in the United States.
More than 12 million people are currently diagnosed with COPD. Many more people may have the disease and not even know it.
It is interesting to note: COPD appears to be one of the few diseases disease which vitamin D TREATS but does not prevent.
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