Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity?-A Case-Control Study
Journal of the American College of Nutrition https://doi.org/10.1080/07315724.2020.1826005
Kun Ye,Fen Tang,Xin Liao,Benjamin A. Shaw,Meiqiu Deng,Guangyi Huang, show all
VitaminDWiki
Reported by Grassroots Health Nov 4, 2020
COVID-19 treated by Vitamin D - studies, reports, videos in VitaminDWiki
As of June 30, the page had: 34 trials, 5 trial results, 20 meta-analyses and reviews, 59 observations, 34 recommendations, 53 associations, 88 speculations, 45 videos see related: Governments, HealthProblems, Hospitals, Dark Skins, 26 risk factors are ALL associated with low Vit D, Recent Virus pages Fight COVID-19 with 50K Vit D weekly Vaccine problems
Top Vitamin D and COVID-19 recent updates
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- COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020
- Vitamin D recommended to fight COVID-19 by 2 groups – Dec 7, 2020
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- 5X more likely to test positive for COVID-19 if low vitamin D in previous 5 years (900,000 people) - Dec 4, 2020
- 5.8 X more likely to die of COVID-19 if low vitamin D - Systematic Review Dec 3, 2020
- Evidence of Vitamin D fighting COVID-19 etc. - take 4,000 IU if less than 20 ng (UK) – Dec 1, 2020
- 3.8 X higher risk of COVID-19 death if low vitamin D – Belgium Nov 25, 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020 Diabetes
- A Medical School COVID-19 protocol includes Vitamin D for all phases – Marik Nov 2020
- Fight COVID-19 without drugs or vaccines, Vitamin D is the single most-studied way – Nov 2020
- Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020
- Higher vitamin D associated with fewer cases and deaths in India Nov 2020
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
Many clinical trials are underway which are testing Vitamin D to fight COVID-19
Download the PDF from VitaminDWiki
Background
As effective medication to treat COVID-19 is currently unavailable, preventive remedies may be particularly important.
Objective
To examine the relationship between serum 25-hydroxy vitamin D (25(OH)D) level and COVID-19 infection, its severity, and its clinical case characteristics.
Methods
This case-control study compared serum 25(OH)D levels and rates of vitamin D deficiency (VDD) between 80 healthy controls and 62 patients diagnosed with COVID-19 and admitted to Guangxi People’s Hospital, China, 2/16/2020–3/16/2020. Cases were categorized into asymptomatic, mild/moderate, and severe/critical disease. Logistic regression analysis was conducted to examine the associations between 25(OH)D level, or VDD, and case status/severity of COVID-19 while controlling for demographics and comorbidities. A threshold level of vitamin D for conveying COVID-19 risk was estimated.
Results
Severe/critical COVID-19 cases were significantly older and had higher percentages of comorbidity (renal failure) compared to mild cases. The serum 25(OH)D concentration in COVID-19 patient was much lower than that in healthy control. And 25(OH)D level was the lowest in severe/critical cases, compared with mild cases. In further, significantly higher rates of VDD were found in COVID-19 cases (41.9%) compared to healthy controls (11.1%). And VDD was the greatest in severe/critical cases (80%), compared with mild cases (36%). These statistically significant associations remained even after controlling for demographics and comorbidities. A potential threshold of 25(OH)D (41.19 nmol/L) to protect against COVID-19 was identified.
Conclusion
Elderly and people with comorbidities were susceptible to severe COVID-19 infection. VDD was a risk factor for COVID-19, especially for severe/critical cases. While further confirmation is needed, vitamin D supplementation may have prevention or treatment potential for COVID-19 disease.