Pediatr Pulmonol. 2020 Oct 5. doi: 10.1002/ppul.25106
Kamil Yılmaz 1, Velat Şen 2
40 Children in Turkey : ages 1 month to 18 years
Turkey has been giving free Vitamin D to all infants for over 10 years
- Turkey stops giving free Vitamin D at age 1 for some reason,
- but it appears that many parents continue with the supplementation
- Rickets reduced 60X - lessons learned by Turkey 2011
Virus and infant-child studies are listed here:
- Children with COVID-19 and low levels of Vitamin D have more severe cases – March 31, 2021
- Vitamin D might reduce Multisystem Inflammatory Syndrome in children – March 2021
- 87 percent of children with COVID–19 had low vitamin D (small study) – Feb 2021
- 13 possible reasons why COVID-19 is less severe in children – Dec 1, 2020
- Vitamin D associated with reduced COVID-19 risks in children - GRH Nov 2020
- Children with low vitamin D far more likely to hospitalized with COVID-19 – Oct 2020
- Respiratory viral infection (RSV) and low vitamin D – July 2020
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- More US infants die in 1st day than in all other developed countries COMBINED (and US gives vaccine in first day) – May 2013
- Hand, Foot, and Mouth disease (virus) strongly associated with low vitamin D – May 2017
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Child is 2 X more likely to get influenza if have older sibling (perhaps closely-spaced birth) – Sept 2017
This was also reported as: Vitamin D associated with reduced COVID-19 risks in children - GRH Nov 2020
Objective: COVID 19 is a global health problem that can result in serious complications. The aim of this study was to investigate the prevalence and clinical importance of vitamin D deficiency in children with COVID-19.
Material and methods: This study includes 40 patients who were diagnosed to have COVID- 19 and hospitalized with the real-time reverse transcription polymerase chain reaction (RT-PCR) method, 45 healthy matched control subjects with normal vitamin D levels. The age of admission, clinical and laboratory data, and 25-hydroxycholecalciferol (25-OHD) levels were recorded. Those with vitamin D levels which are below 20 ng/ml were determined as Group 1 and those with ≥20 ng/ml as Group 2.
Results: Patients with COVID- 19 had significantly lower vitamin D levels 13.14 μg/L (4.19-69.28) than did the controls 34.81(3.8-77.42) μg/L (p < 0.001). Patients with COVID- 19 also had significantly lower serum phosphorus (4.09±0.73 vs. 5.06±0.93vs (U/L) (p<0.001) values compared with the controls. The symptom of fever was significantly higher in COVID- 19 patients who had deficient and insufficient vitamin D levels than in patients who had sufficient vitamin D levels (p=0.038). There was a negative correlation found between fever symptom and vitamin D level (r=-0.358, p = 0.023).
Conclusion: This is the first to evaluate vitamin D levels and its relationship with clinical findings in pediatric patients with COVID-19. Our results suggest that vitamin D values may be associated with the occurrence and management of the COVID-19 disease by modulating the immunological mechanism to the virus in the pediatric population. This article is protected by copyright. All rights reserved.