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Children with fracture history have lower vitamin D levels (behind paywall) – June 2016

Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture.

J Endocrinol Invest. 2016 Jun 16. [Epub ahead of print]

See also VitaminDWiki

The items in Falls-Fractures and Infant-Child are listed here:

The items in Bone Health and Infant-Child are listed here:


Al-Daghri NM1,2, Aljohani N3,4, Rahman S5,3, Sabico S5,3, Al-Attas OS5,3, Alokail MS5,3, Al-Ajlan A6, Chrousos GP7.
1Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aldaghri2011 at gmail.com.
2Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aldaghri2011 at gmail.com.
3Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
4Obesity, Endocrine and Metabolism Center, King Fahad Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, 11461, Saudi Arabia.
5Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
6Department of Clinical Lab Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia.
7First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece.

BACKGROUND:
The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children.
MATERIALS AND METHODS:
This cross-sectional study was conducted in 1022 Saudi children without fracture history [476 boys (age 14.56 ± 1.81, BMI 22.38 ± 5.81) and 546 girls (age 13.57 ± 1.67, BMI 22.24 ± 4.94)] and 234 Saudi children with a history of fracture [148 boys (age 14.25 ± 1.39, BMI 22.66 ± 6.08) and 86 girls (age 13.76 ± 1.35, BMI 21.33 ± 1.35)]. Anthropometric and fasting serum biochemical data were collected. Serum 25-hydroxyvitamin D level was assessed using electrochemiluminescence.
RESULTS:
Mean circulating 25-hydroxyvitamin (25OH) D level in subjects with a history of fracture was significantly lower in both boys (p < 0.01) and girls (p < 0.01) than those without, however both groups had low mean 25(OH)D levels. Furthermore, age was positively associated with 25-hydroxyvitamin D in boys (p < 0.05) and negatively in girls (p < 0.05) with a history of fracture.
CONCLUSION:
In conclusion, vitamin D levels were significantly lower in children with a history of bone fractures in both boys and girls than those without such a history; even in the absence of fracture history, vitamin D status correction is warranted in the general Saudi pediatric population.

PMID: 27312860

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