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Chance of dying within 1 month of entering hospital is 45 percent higher if low vitamin D – July 2013

Pre-hospital Vitamin D Concentration, Mortality, and Bloodstream Infection in a Hospitalized Patient Population

The American Journal of Medicine; Volume 126, Issue 7, July 2013, Pages 640.e19–640.e27
Nancy Lange, MD, MPHa,
Augusto A. Litonjua, MD, MPHb,
Fiona K. Gibbons, MDc,
Edward Giovannucci, MD, ScDd,
Kenneth B. Christopher, MDe, kbchristopher at partners.org
a Pulmonary Division, Brigham and Women's Hospital, Boston, Mass
b Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, Mass
c Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Mass
d Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Mass
e Renal Division, Brigham and Women's Hospital, Boston, Mass

Objective: The study objective was to examine the association between pre-hospital serum vitamin D concentration and mortality after hospitalization.

Methods: We performed a retrospective cohort study in 2 tertiary hospitals in Boston, Mass, on 23,603 patients aged ≥18 years in whom 25(OH)D was measured before hospitalization between 1993 and 2010. The main outcome measures were all-cause mortality by day 30 post-hospital admission, in-hospital mortality, and community-acquired bloodstream infection.

Results: Compared with patients with pre-hospital 25(OH)D ≥30 ng/mL, patients with pre-hospital 25(OH)D ≤15 ng/mL or 15 to 30 ng/mL have higher odds of mortality 30 days after hospital admission.

After adjustment for age, gender, race, Deyo-Charlson index, season, type (surgical vs medical), creatinine, blood urea nitrogen, hematocrit, and time between 25(OH)D draw and hospital admission, the adjusted odds ratio (OR) of 30-day mortality in patients with 25(OH)D ≤15 ng/mL is 1.45 (95% confidence interval [CI], 1.21-1.74; P < .0001) and the adjusted OR of 30-day mortality in patients with 25(OH)D 15 to 30 ng/mL is 1.30 (95% CI, 1.10-1.54; P = .003) both compared with patients with pre-hospital 25(OH)D ≥30 ng/mL. In a subgroup analysis of patients who had blood cultures drawn (n = 5628), pre-hospital serum 25(OH)D ≤15 ng/mL was associated with increased odds of community-acquired bloodstream infection (adjusted OR, 1.29; 95% CI, 1.06-1.57; P = .01) relative to patients with 25(OH)D ≥30 ng/mL.

Conclusions: Analysis of 23,603 hospitalized patients identified both 25(OH)D ≤15 ng/mL and 25(OH)D 15 to 30 ng/mL before hospital admission as associated with the odds of all-cause patient mortality at 30 days after hospitalization. In addition, pre-hospital serum 25(OH)D ≤15 ng/mL is significantly associated with the odds of community-acquired bloodstream infection.


Dr. Ray Matthews is a US surgeon who prefers that his elective surgery patients have 50-70 ng/ml of vitamin D
Restore your vitamin D levels before entering the hospital! Restoration can be done very quickly,

See also VitaminDWiki

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